Full Text HL-97-007 MINORITY INSTITUTION FACULTY MENTORED RESEARCH SCIENTIST DEVELOPMENT AWARD NIH GUIDE, Volume 26, Number 14, May 2, 1997 RFA: HL-97-007 P.T. 34, FF Keywords: Biomedical Research Training Blood Diseases Cardiovascular Diseases Pulmonary Diseases Sleep Disorders National Heart, Lung, and Blood Institute Letter of Intent Receipt Date: July 1, 1997 Application Receipt Date: August 25, 1997 THIS RFA USES "JUST-IN-TIME" CONCEPTS. THE FULL RFA INCLUDES DETAILED MODIFICATIONS TO STANDARD APPLICATION INSTRUCTIONS THAT MUST BE FOLLOWED WHEN PREPARING APPLICATIONS IN RESPONSE TO THIS RFA. PURPOSE This program provides research support to faculty members at minority institutions who have the interest and potential to conduct state of the art research in the areas of cardiovascular, pulmonary, or hematologic disease, or in sleep disorders. This is an effort to enhance the institution's science programs, and to assist in the acquisition of "hands on" research opportunities for minority students at the applicant's institution. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, Minority Institution Faculty Mentored Research Scientist Development Award, is related to the priority area of heart disease, stroke, tobacco, educational and community-based programs, environmental health, maternal and infant health, diabetes and chronic disabling diseases, and HIV infection. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-1 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone: 202-512-1800). ELIGIBILITY REQUIREMENTS Minority School A minority school is defined as a domestic medical or non-medical college, university or equivalent school in which students of minority ethnic groups including Blacks, Hispanics, American Indians, and Asian or Pacific Islanders comprise a majority or significant proportion of the school enrollment. The commitment of the institution to the faculty candidate's research and development must clearly be presented in the application, including statement(s) from the Dean and the candidate's departmental chair. These signed statements must also indicate that the candidate will be provided with the amount of time and effort designated in the application to accomplish the research goals stated in the proposal. Because the NHLBI views this commitment as vital to the success of the program, the Institute will closely monitor this aspect of the program if an award is made. Faculty Development Award Candidate Candidates for this award are minority school faculty members who (1) are citizens of the United States, non-citizen nationals or permanent residents at the time of application, (2) have a doctoral degree or equivalent in a biomedical or behavioral science, (3) wish to receive specialized training in cardiovascular, pulmonary, hematologic, or sleep disorders research, and (4) have the background and potential to benefit from the training. Mentor at Research Center Each candidate must also identify and complete arrangements with a nearby mentor (within approximately 100 miles) who is recognized as an accomplished investigator in the research area proposed and who will provide guidance for the awardee's development and research plan. Arrangements with mentors at institutions greater than 100 miles from the applicant institution will be considered, but must be strongly justified and clearly outlined in the application. Plans for the intensive training during the summer period (2-3 months) as well as during the academic years should be developed with the mentor. The commitment of the mentor and his institution to both the summer and academic year training period must be evidenced in the application. A statement of commitment from the mentor's departmental chair must also be included in the application. The mentor must provide an annual evaluation of the faculty member's career development. This evaluation is to be included as part of the Application for Continuation Grant if an award is made. Concurrent and Subsequent Applications for NIH Research Support Applicants may not apply for other Public Health Service research grant support or its equivalent at the time of the Minority Institution Faculty Mentored Research Scientist Development Award application, nor may they apply concurrently for any other type of career development award. They may apply for and accept NIH research grant support subsequent to award of the Minority Institution Faculty Mentored Research Scientist Development Award. MECHANISM OF SUPPORT For this RFA, no detailed budget is required. However, total direct costs for all years must be provided in addition to the name, role on project, percent effort and narrative justification for all project personnel. Instructions for completing the Biographical Sketch have also been modified. In addition, Other Support information for the applicant and the application Checklist page are not required as part of the initial application. However, Other Support information is required for the sponsor and co-sponsor. If there is a possibility for an award, necessary budget, Other Support and Checklist information will be requested by NHLBI staff following the initial review. The Supplemental Instructions section of the full RFA provides specific details of modifications to standard PHS 398 application kit instructions. The programs of the National Heart, Lung, and Blood Institute are identified in the Catalog of Federal Domestic Assistance, numbers 93.837, 93.838, 93.839, and 93.231. The mechanism of support for this activity will be the career development grant, awarded under the authority of the Public Health Service Act, Title III, Section 301 (Public Law 78-410, as amended, 42 Part 241). The regulations (Code of Federal Regulations, Title 42, Part 52 and Title 45, Part 74) and policies which govern the research grant programs of the National Institutes of Health will prevail. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or to Health Systems Agency Review. The award of grants pursuant to this announcement is contingent upon availability of appropriated funds. RESEARCH OBJECTIVES Background Measurements of health status indicate that Americans today are, on the whole, healthier than at any other time in our history. Life expectancy has increased while infant mortality statistics indicate that fewer infants are dying at birth or in the first few months of life. Diseases that disabled or killed at the start of the century have virtually disappeared. In spite of this national trend toward better health, there is a continuing disparity in the burden of death and illness experienced by Blacks and other minority Americans. This segment of the population continues to be over represented among those in poor health and with remarkably higher death rates from cardiovascular, pulmonary, and hematologic diseases. Despite a recent decline in the death rate from coronary heart disease, cardiovascular disease continues to be the number one cause of death in the United States. Cardiovascular disease accounts for almost one million deaths annually. An estimated 68 million Americans are estimated to have diseases of the heart and blood vessels, resulting in a large burden of acute and chronic illness and disability. Heart and blood vessel diseases cost the economy tens of billions of dollars per year in lost wages, reduced productivity, and expenses for medical care. Diseases of the lung constitute a major national health problem. About one in every five persons has some chronic respiratory problem resulting in an annual estimated cost to the nation of over $29 billion. In the newborn, the most common cause of death is neonatal respiratory distress syndrome (RDS). Neonatal RDS may be implicated in development of adult respiratory diseases as well. Of the adult respiratory diseases, emphysema and chronic bronchitis are major causes of death. Fibrotic and immunologic lung diseases are serious causes of lung problems in the young adult. Asthma, emphysema and chronic bronchitis represent particularly pressing health problems, affecting an estimated 17 million Americans. Moreover, the death rate and prevalence of these conditions have increased at an alarming rate over the past 15 years. As a disabling disease, chronic obstructive pulmonary disease is a leading cause of worker retirement on Social Security disability payments. Disorders of the blood, including congenital or acquired disorders or deficiencies, are critical contributors to health problems of mankind. As a consequence, they are major causes of death and disability in the United States. Disorders of the blood affect not only the blood itself, but the tissues and organs through which it flows. Recent research findings have revealed the widespread involvement of thrombosis in the pathology of numerous disorders, including the development of atherosclerosis and coronary thrombosis. Aggressive therapy for cancer has resulted in the increased susceptibility of patients to bleeding disorders and has increased the demand for blood products for therapeutic purposes. A significant segment of the population has inherited blood disorders, such as sickle cell disease, hemophilia, or Cooley's anemia, which require life-long hematologic attention and blood product support. Other diseases may be acquired or represent temporary demands, such as transfusion therapy as a result of surgical or accidental trauma. Research opportunities in blood resources and transfusion medicine range from basic to clinical. They cover such diverse topics as the development of new blood products, methods to improve and assure the stability and safety of these products, and ways to improve the benefits and safety of transfusion. Note: Within NHLBI, the term "hematologic" covers research on thrombosis and hemostasis, immunohematology, hematopoiesis, thalassemia, blood cell disorders, sickle cell disease, transfusion medicine including blood component and derivative therapy, blood substitutes and blood resource management, aspects of AIDS-products in AIDS prevention and treatment, and AIDS-related bone marrow and hematologic disorders. Other Institutes of the NIH are responsible for research on disorders of white cells, including the leukemias and other blood malignancies, and basic immunology related to the lymphoid system. Therefore NHLBI cannot provide support for such studies. The National Heart, Lung, and Blood Institute (NHLBI) continues its commitment to address these important medical challenges. One way of meeting these challenges is to increase the pool of well trained investigators, especially in minority groups where the proportion of biomedical investigators is strikingly lower than the percentage of minority U.S. citizens. While 12 percent of the population is Black, less than 0.25 percent of persons holding a Ph.D. in science are Black. The figures are even lower for Black Ph.D.s in the biomedical sciences. Furthermore, the number of doctorates, both M.D.s and Ph.D.s, in other ethnic minority groups (such as American Indians or Hispanics) is proportionally lower than for Blacks. Vigorous recruitment is underway throughout the government, academic institutions, hospitals, research institutions, and industry. The Minority Institution Mentored Research Scientist Development Award is designed to address this critical need by increasing the research and academic capabilities of faculty members at minority schools. In doing so, the pool of well trained biomedical and behavioral investigators in cardiovascular, pulmonary, and hematologic research will be enlarged. Furthermore, their undergraduate and graduate students, most of whom will be underrepresented minority individuals, will become more cognizant of research opportunities in these areas. Thus, the NHLBI anticipates that the Minority Institution Mentored Research Scientist Development Award will help meet this future challenge by providing research support to faculty members at minority institutions who have the interest and potential to conduct state of the art research in the areas of cardiovascular, pulmonary, or hematologic disease, or in sleep disorders. PROGRAM GOALS The major goals of the Minority Institution Faculty Mentored Research Scientist Development Award Program are as follows: Develop or enhance the research skills and abilities of the awardee. Establish collaborative linkages with other investigators that lead to "cutting edge" research opportunities. Publish results in peer-reviewed journals. Enhance skills in grantsmanship to increase the likelihood of obtaining additional grant support from the NIH and other sources. Enhance the science program at the applicant's institution by: o serving as a resource for other scientific faculty; o incorporating new skills and knowledge into the academic curriculum; and o developing or enhancing scientific seminar series at the applicant's institution. Provide/assist in the acquisition of "hands on" research opportunities for minority students at the applicant's institution. Implementation The awards will be made to the minority institution on behalf of the awardee. Each award will have a duration of five years and is non-renewable. These awards may not be transferred to another institution or another faculty member. Funding beyond the first year of the grant is contingent upon satisfactory progress during the preceding year. The progress of the Minority Institution Faculty Mentored Research Scientist Development Award recipient will be reviewed annually using information in the non-competitive renewal application to determine whether the award should be continued. The ability of the department chairman to provide the awardee with the agreed-upon time and effort will be monitored closely. In addition, to assess the effectiveness of the program in fulfilling its objectives, the Institute intends to follow the progress of the recipient for a period of five years after completion of each grant to determine: (1) the investigator's professional affiliation(s); (2) his or her record of subsequent grant or contract support; (3) his or her record of scientific publications; and (4) the institution's research programs. PROVISIONS OF THE AWARD Salary The awardee will receive salary support up to a maximum of $50,000 plus fringe benefits per year for five years. All funds must be used to support the awardee. The level of support will be based upon the candidates' actual salary and must be consistent with the established salary structure of the minority institution for persons of equivalent qualifications, experience, and rank. The actual salary level will be determined by the proportion of effort devoted to this program. Awardees must commit 100 percent of effort during summer and/or off quarter periods and at least 25 percent of effort during the academic year. Supplementation of the awardee's salary from non-Federal sources is permissible. Supplementation of the awardee's salary from other Federal funds is not allowed unless explicitly authorized by both the program from which funds are derived and the NHLBI. In no case may other NIH funds be used to supplement salary support of the awardee. In addition to salary support for the candidate, support for up to 5 percent of the mentor's salary during the summer experience may also be requested. If funds are to be transferred to the mentor's institution for the mentor's salary or for research expenses, arrangements for the transfer of funds and the conduct of activities should be formalized in a contract or written agreement with the mentor's institution. Research Support Up to $30,000 per year beyond that requested for the candidate's and mentor's salaries will be provided for research support. Details regarding the apportionment of these funds between the minority institution and the research center must be worked out with the mentor at the research center and agreed to by representatives of both institutions. A statement of agreement must be provided in the application. These research support funds may be used for: Personnel: support for students or other technical personnel; Equipment: limited to specialized research equipment essential to the proposed program; in accordance with PHS policy, title to such equipment will vest with the grantee institution; Supplies: consumable supplies essential to the proposed program; Travel: domestic travel for the awardee that is essential to the proposed program; and Other: publication costs, computer costs, or other costs necessary for the research program. Facilities and administrative (indirect) costs will be provided for at a rate of 8 percent of the total direct costs of each award, exclusive of equipment. The indirect cost rate on a subcontract with the mentor's institution may not exceed 8 percent. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH-supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification is provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing research involving human subjects should read the "NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical Research," which have been published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and in the NIH Guide for Grants and Contracts, Vol. 23, No. 11, March 18, 1994. LETTER OF INTENT Prospective applicants are asked to submit by, July 1, 1997, a letter of intent that includes the name, address, and telephone number of the Principal Investigator, the identities of other key personnel and participating institutions, and the number and title of the RFA in response to which the application may be submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information that it contains allows NIH staff to estimate the potential review workload and to avoid conflict of interest in the review. The letter of intent is to be sent to Dr. C. James Scheirer at the address listed under APPLICATION PROCEDURES. APPLICATION PROCEDURES The research grant application form PHS 398 (rev. 5/95) is to be used in applying for these grants. Applications kits are available at most institutional offices of sponsored research and may be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/710-0267, email: ASKNIH@odrockm1.od.nih.gov. Special supplemental instructions necessary for preparing the application are included in the program guidelines, which must be obtained by contacting the appropriate individual listed under INQUIRIES prior to preparation of the application. The RFA label available in the PHS 398 application from must be affixed to the bottom of the face page of the application. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition the RFA title and number must be typed on line 2 of the face page of the application form and the YES box must be marked. Send the completed application and four signed exact photocopies to: DIVISION OF RESEARCH GRANTS NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) One additional copy of the application must be sent to: Dr. C. James Scheirer Division of Extramural Affairs National Heart, Lung, and Blood Institute 6701 Rockledge Drive, MSC 7924 Bethesda, MD 20892-7924 Telephone: (301) 435-0288 FAX: (301) 480-3541 REVIEW CONSIDERATIONS All applications will be reviewed for scientific and technical merit by the Research Training Review Special Emphasis Panel of the Division of Extramural Affairs, NHLBI, followed by a second level review by the National Heart, Lung, and Blood Advisory Council. Review Criteria The factors to be considered in the evaluation of the proposed training program are: the overall merit of the candidate's five year plan for research and the development of research skills; the candidate's background and the candidate's potential to meet the goals of the program, which are to develop their research skills, strengthen their laboratory research program, and enhance the scientific program at the minority institution; the candidate's commitment to a research career; the ability of both the minority institution and the training center to provide facilities, resources, and opportunities necessary for the candidate's research development; the qualifications, ability, and plans of the sponsor who will provide the candidate with the guidance necessary for career development in research; and the institution's commitment to the development of the candidate. AWARD CRITERIA The following will be considered in making funding decisions: o Technical merit of the application as determined by peer review; o Availability of funds; o Program balance among the research areas of the announcement. INQUIRIES Special Supplemental Instructions for preparing the application are included in the full Program Guidelines. Potential applicants must contact NHLBI staff to obtain these guidelines prior to preparation of an application. Michael Commarato, Ph.D., or Beth Schucker, M.A. Division of Heart and Vascular Diseases National Heart, Lung, and Blood Institute 6701 Rockledge, MSC 7940 Bethesda, MD 20892-7940 Phone: (301) 435-0530 FAX: (301) 480-1454 Email: michael_commarato@nih.gov or beth_schucker@nih.gov Mary Reilly, M.S., or Ann Rothgeb Division of Lung Diseases National Heart, Lung, and Blood Institute 6701 Rockledge Drive, MSC 7952 Bethesda, MD 20892-7952 Phone: (301) 435-0222 FAX: (301) 480-3557 E-mail: mary_reilly@nih.gov; ann_rothgeb@nih.gov LeeAnn Jensen, Ph.D. Division of Blood Diseases and Resources National Heart, Lung, and Blood Institute 6701 Rockledge Drive, MSC 7950 Bethesda, Maryland 20892-7950 Phone: (301) 435-0065 FAX: (301) 480-1060 E-mail: leeann_jensen@nih.gov Thomas Blaszkowski, Ph.D. Division of Epidemiology and Clinical Applications National Heart, Lung, and Blood Institute 6701 Rockledge Drive, MSC 7938 Bethesda, Maryland 20892-7938 Phone: (301) 435-0433 FAX: (301) 480-1864 E-mail: thomas_blaszkowski@nih.gov James Kiley, Ph.D. National Center for Sleep Disorders Research National Heart, Lung, and Blood Institute 6701 Rockledge Drive, MSC 7920 Bethesda, Maryland 20892-7920 Phone: (301) 435-0199 FAX: (301) 480-3451 E-mail: james_kiley@nih.gov For fiscal and administrative matters, please contact: William W. Darby Grants Operations Branch, Heart Section Division of Extramural Affairs National Heart, Lung, and Blood Institute 6701 Rockledge Drive, MSC 7926 Bethesda, Maryland 20892-7926 Phone: (301) 435-0177 FAX: (301) 480-0422 E-mail: william_darby@nih.gov Raymond L. Zimmerman Grants Operations Branch, Lung Section National Heart, Lung, and Blood Institute 6701 Rockledge Drive, MSC 7926 Bethesda, Maryland 20892-7926 Phone: (301) 435-0171 FAX: (301) 480-3310 E-mail: raymond_zimmerman@nih.gov Jane Davis Grants Operations Branch, Blood Section Division of Extramural Affairs National Heart, Lung, and Blood Institute 6701 Rockledge Drive, MSC 7926 Bethesda, Maryland 20892-7926 Phone: (301) 435-0166 FAX: (301) 480-3310 E-mail: jane_davis@nih.gov AUTHORITY AND REGULATION This program is described in the Catalog of Federal Domestic Assistance numbers 93.837, 93.838, 93.839, and 93.231. Awards are made under the authority of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grant policies and Federal Regulations at 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant and contract recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people. .
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