Full Text CA-92-21 TRANSFER OF NEW BIOSTATISTIC METHODS TO CANCER EPIDEMIOLOGY NIH GUIDE, Volume 21, Number 27, July 31, 1992 RFA: CA-92-21 P.T. 34 Keywords: Cancer/Carcinogenesis Epidemiology Statistics National Cancer Institute Letter of Intent Receipt Date: September 30, 1992 Application Receipt Date: November 12, 1992 PURPOSE The Division of Cancer Etiology of the National Cancer Institute (NCI) announces the availability of a Request for Applications (RFA) to stimulate interest in small projects for the transfer of theoretical biostatistical methodologies to application in cancer epidemiologic studies. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, Transfer of New Biostatistic Methods to Cancer Epidemiology, is related to the priority area of cancer. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal Government. Applications from minority and women investigators are encouraged. MECHANISM OF SUPPORT This program will be supported through National Institute of Health (NIH) traditional research project grants (RO1). Responsibility for the planning, direction, and execution of the proposed research will be solely that of the applicant. Awards will be administered under PHS grants policy as stated in the PHS Grants Policy Statement, DHHS Publication No. (OASH) 82-50,000 revised October 1, 1990. The RFA is a one-time solicitation. The total project period for applications submitted in response to the present RFA may not exceed three years. For competing supplemental applications, if the remaining length of time on the parent project period is less than three years, the period of requested supplemental support must be adjusted accordingly. Competitive continuation applications will compete with all other unsolicited applications and be reviewed by Division of Research Grants (DRG) study sections. If the NCI determines that there is a sufficient continuing program need, the NCI may announce a request for renewal applications. FUNDS AVAILABLE Approximately $500,000 in total costs will be committed for the first year to fund applications that are submitted in response to the RFA. The intent is to fund 5 to 10 research awards. The funding level is dependent on the receipt of a sufficient number of applications of high scientific merit. Although this program is provided for in the financial plans of the NCI, the award of grants pursuant to this RFA is also contingent upon the availability of funds for this purpose. RESEARCH OBJECTIVES Background A decade or two ago, a biometry textbook, a medical statistics book, and an understanding of the basic principles of statistics provided applied biostatisticians with sufficient experimental designs and methodologic techniques to analyze most problems encountered in cancer research. Meanwhile, theoretical statisticians explored statistical problems of general interest without focussing on specific applications. Advances in biotechnology and high-speed computing tools have driven the development of specialties and even subspecialties in biostatistics. Advances have been made in methods for analyzing cancer survival data, understanding data with missing elements, allowing for errors in variables, fitting random effects models, and utilizing the bootstrap and other computationally intensive. Most of this material is available only in technical journals and specialized textbooks on theoretical statistics. There are strong factors that limit the translation of methodological theory to applied cancer research. Theoretical biostatisticians are usually interested in finding solutions to general problems and publishing in theoretical journals. Therefore, there is a need to facilitate transfer of new methodologies for use by applied biostatisticians working in cancer epidemiology. Other The purpose of this RFA is to stimulate collaborations and interactions among theoretical and applied biostatisticians, cancer epidemiologists, computer scientists, and programmers and to promote the introduction of appropriate theoretical methods to epidemiologic projects in cancer research. This initiative proposes to link peer-approved activities to provide a mechanism for facilitating the transfer of new biostatistical methodologies to applied biostatisticians and epidemiologists. The goal is to ensure the validation and integration of promising new statistical and computing techniques into epidemiologic studies. Projects funded by this initiative will lead to substantial cost savings by developing computer programs and analytical techniques that can be shared by numerous projects. This RFA encourages the development of 5 to 10 small projects that will each provide enough support for one key researcher with expertise in the application of theory to real-life problems in cancer research, with appropriate collaborations. Applicants for these grants will need to show an in-depth knowledge of the biostatistical literature in the area they propose and demonstrate the willingness of appropriate collaborators to provide theoretical input and/or data sets for methodological testing and exploration. We especially encourage research relevant to studies of data sets of breast, ovarian, prostate, and/or cervical cancer. This mechanism should permit a range of small projects that might be used by Master's and Ph.D. level biostatisticians and epidemiologists to tailor and apply new biostatistical designs or methodology for use in specific cancer projects. There are many possible approaches, including: (1) biostatistical consultation on an epidemiologic study that compares the use of conventional statistical procedures to theoretical methodology of greater applicability to epidemiologic cancer research and (2) development of an expository application for cancer research of theoretical statistical methodology from a dissertation or publication, under the tutorship of the dissertation advisor or with the collaboration of the publication's authors. The projects responsive to the RFA can propose the study of a cancer epidemiology problem, that is, a potential application, seeking out possibilities in the theoretical literature, and testing these against actual data sets, making the results available to the scientific community, or to look at a theoretical article or a general method, such as those listed below, developing examples of applications by testing against real data sets, and developing a public- domain program or function accessible on university-based electronic bulletin boards for cancer researchers. The outcomes of these projects could include published articles on the translation of methodologic theory into computationally feasible techniques, presentations at scientific meetings, lecture notes, or efficient, well- documented, and well-written codes for user-ready computer programs/functions that can be made available to the scientific community. (It is not the intent of this initiative to fund the development of commercial programs or packages.) Subjects of interest include, but are not limited to: o Cox regression model o Logistic regression model, ordered logistic regression o Polychotomous regression model o Sequential trials; group sequential trials o Multiple endpoints o Surrogate endpoints o Time-dependent covariates o Censored data; left and right truncation o Meta-analysis o Data augmentation methods (Gibbs, bootstrap and jackknife methods) o Martingales: counting processes in survival analysis o Frailties o Repeated measures o Determination of maximum tolerated dose o Surrogate markers of exposure LETTER OF INTENT Prospective applicants are requested to submit, by September 30, 1992, a letter of intent that includes a descriptive title of the proposed research, the name and address of the Principal Investigator, the names of other key personnel, the participating institutions, and the number and title of the RFA in response to which the application is being submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications,the information that it contains is helpful in planning for the review of applications. It allows NCI staff to estimate the potential review workload. The letter of intent is to be sent to: Dr. Marthana C. Hjortland Extramural Programs Branch Division of Cancer Etiology National Cancer Institute 6130 Executive Boulevard Executive Plaza North, Suite 535 Rockville, MD 20892 Telephone: (301) 496-9600 APPLICATION PROCEDURES Applications are to be submitted on form PHS 398 (rev. 9/91), available at most institutional business offices and from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Room 449, Westwood Building, 5333 Westbard Avenue, Bethesda, Maryland 20892, telephone 301/496-7441. The format and instructions applicable to research grant applications must be followed. The RFA label available in the application form PHS 398 must be affixed to the bottom of the face page. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, the number and title of the RFA must be typed on line 2a of the face page of the application and YES must be checked. Submit a signed, typewritten original of the application, including the Checklist, and three signed, exact photocopies in one package to the Division of Research Grants the address below. The photocopies must be clear and single-sided. Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** At the time of submission, two additional copies of the application must also be sent to: Referral Officer Division of Extramural Activities National Cancer Institute Westwood Building, Room 838 5333 Westbard Avenue Bethesda, MD 20892 Applications must be received by November 12, 1992. If an application is received after that date, it will be returned without review. If the application submitted in response to this RFA is substantially similar to a research grant application already submitted to the NIH for review, but has not yet been reviewed, the applicant will be asked to withdraw either the pending application or the new one. Simultaneous submission of identical applications will not be allowed, nor will essentially identical applications be reviewed by different review committees. Therefore, an application cannot be submitted in response to this RFA that is essentially identical to one that has already been reviewed. This does not preclude the submission of substantial revisions of applications already reviewed, but such applications must include an introduction addressing the previous critique. REVIEW CONSIDERATIONS Upon receipt, applications will be reviewed initially by the Division of Research Grants (DRG) for completeness. Incomplete applications will be returned to the applicant without further consideration. Preliminary evaluation for responsiveness to the RFA is an NCI program staff function. If an application is judged to be nonresponsive, the applicant will be contacted and given an opportunity to have it considered along with other unsolicited grant applications. Applications may be triaged by NCI staff on the basis of relative competitiveness. The NCI will withdraw from further competition those applications judged to be non-competitive for award and notify the applicant Principal Investigator and institutional official. Those applications judged to be competitive will undergo further scientific merit review. Those applications that are complete and responsive will be evaluated in accordance with the criteria stated below for scientific/technical merit by an appropriate peer review group convened by the NCI. The second level of review will be provided by the National Cancer Advisory Board. Review criteria for RFAs are generally the same as those for unsolicited research grant applications. Those factors considered in the review include: o extend to which application addresses research objectives of RFA; o overall scientific merit; o quality of collaborations to facilitate transfer; o qualifications, research experience, and time commitment of investigators; o adequacy of facilities and resources; o cost effectiveness of the application. The review group will critically examine the submitted budget and will recommend an appropriate budget and period of support for each scored application. AWARD CRITERIA The earliest anticipated of award is July 1, 1993. In addition to technical merit, the overall applicability to analysis of data from cancer research studies will be taken into consideration in making an award. INQUIRIES Written and telephone inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Dr. Marthana C. Hjortland Extramural Programs Branch Epidemiology and Biostatistics Program Division of Cancer Etiology National Cancer Institute 6130 Executive Boulevard Executive Plaza North, Suite 535 Rockville, MD 20892 Telephone: (301) 496-9600 Direct inquiries regarding fiscal matters to: Ms. Jean M. Cahill Supervisory Grants Management Specialist National Cancer Institute 6120 Executive Boulevard Executive Plaza South, Suite 243 Rockville, MD 20892 Telephone: (301) 496-7800, ext. 47 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance, No. 93.393, Cancer Cause and Prevention Research. Awards will be made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grant policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. .
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