Full Text AA-92-03 ALCOHOL RESEARCH CENTER GRANTS NIH GUIDE, Volume 21, Number 20, May 29, 1992 RFA AVAILABLE: AA-92-03 P.T. 34 Keywords: Alcohol/Alcoholism Etiology Diagnosis, Medical Disease Prevention+ Disease Control+ Rehabilitation/Therapy, Emotional National Institute on Alcohol Abuse and Alcoholism Letter of Intent Receipt Date: October 1, 1992 Application Receipt Date: December 10, 1992 PURPOSE The National Institute on Alcohol Abuse and Alcoholism (NIAAA) provides grant support for Alcohol Research Centers to conduct interdisciplinary research on alcoholism and alcohol abuse. The Center grants program is interrelated with and complementary to all other research support mechanisms and scientific activities that comprise the NIAAA programs of research on the nature, causes, diagnosis, treatment, control, prevention, and consequences of alcohol abuse and alcoholism. A center is expected to be a source of scientific excellence and, through sustained excellence, to become a significant regional or national research resource. In addition, the applicant institution is expected to afford opportunities for research training to persons from various disciplines and professions. Support from the initial five-year grant awards for two of the existing centers will expire on November 30, 1993. Research within each of these two centers is organized around a central theme, respectively, alcohol and aging, and alcohol and immunology including the acquired immunodeficiency syndrome (AIDS)/human immunodeficiency virus (HIV) infection. It is the intent of NIAAA to continue to support a center addressed to research questions on alcohol and aging. It is also the intent of the NIAAA to continue to support a center that addresses research issues on alcohol and immunology, although other themes may be considered. Applications for new centers will be evaluated with applications from currently funded centers seeking renewal support beyond November 30, 1993. Center grants are typically awarded for a five-year period. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This Request for Applications (RFA), Alcohol Research Center Grants, is related to the priority area of alcohol abuse and alcoholism reduction. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0), or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, D.C. 20402-9325, telephone (202) 783-3238. ELIGIBILITY REQUIREMENTS Any domestic public (non-Federal) or private non-profit or for-profit institution may apply for a center grant. However, the proposed center must be affiliated with an institution, such as a university, medical center, or research center that has the resources to sustain a long- term, coordinated research program. An applicant institution must demonstrate the ability to attract high-quality scientists from biomedical, behavioral, and/or social science disciplines who are willing to make a long-term commitment to research. An application must also have a detailed five-year plan for a proposed research program. In addition, the applicant must assure that research training opportunities will be available. Women and minority investigators are encouraged to apply. MECHANISM OF SUPPORT A Specialized Center Grant (P50) is a comprehensive, broadly based multidisciplinary, multi-investigator, long-term program of combined research and research support activity planned around a specific major research objective or research theme. In addition to providing support for shared resources, this type of center supports a full range of basic, developmental, clinical, and/or applied research components; allows for growth and development through pilot projects; and is intended to provide state-of-the-art leadership in the alcohol field. Terms and Conditions of Support Center grant funds may be requested for support of core components and individual research components associated with the center program. Core resources may include, for example, salaries of personnel responsible for management of the center, services and facilities to be shared by center personnel, program enrichment activities such as special lectures, visiting scientists, symposia, seminars, and shops, and costs related to dissemination of research information to the scientific community and lay public. Funds may be requested for costs associated with individual research components which are part of the center program. Examples of such costs include: research staff salaries, supplies, travel, special consultation, research patient costs, publication costs, and the like. Funds also may be requested for the allowable indirect costs of the applicant organization. In addition, costs of advisory committees, steering committees, and consultants may be included in the administrative core. Consultants for specific research components must be included in the budgets for those components. If committees are included, specific plans as to how the committees will be selected and how they will function must be presented in the application. Alcohol Research Center grant funds may be used only for costs that are necessary to carry out the research and research support activities of the center program and must be in conformance with HHS cost principles (encompassed in 45 CFR Part 74) and the Public Health Service Grants Policy Statement (Rev. 10/1/90). Funds provided under this program may not be used for the purchase of land; nor for the purchase, construction, preservation, and repair of any building. However, costs of alteration and renovation of existing facilities necessary to accomplish the objectives of the grant may be allowed subject to PHS grants policy limitations. Funds provided through center grants may not be used for support of trainee stipends, fees, and other expenses directly relating to training activities. Support will be provided for a period of up to five years (renewable for subsequent periods) subject to continued availability of funds and scientific progress. Applicants may request up to $1.7 million total cost (including direct and indirect costs combined) per year. The actual amount of support awarded will depend upon consideration of factors listed in the section entitled, AWARD CRITERIA. The center grant is neither expected nor intended to cover all costs of running a successful Alcohol Research Center program. Research and training activities associated with the center may receive additional funding from Federal sources and from State and local sources. The NIAAA expects and encourages the institution and scientists attracted to such centers to seek and compete actively for such funding. Research staff in funded centers may submit applications for independent research project grants for support of research projects that do not overlap with the center project. Requests for funds to expand the scope or number of research components within the center grant must be discussed with NIAAA staff before an application is prepared. Centers will be required to submit detailed annual progress reports including substantive information about research results to date, status of ongoing research, research plans for the next year, and any modifications in long-term research plans. Also required are reporting of inventions, reports of expenditures, final reports, and other reports in accordance with PHS policy. FUNDS AVAILABLE It is estimated that approximately $3-4 million will be available in FY 1994 to fund approximately two centers. RESEARCH OBJECTIVES All proposed research to be conducted within a center must be clearly directed toward one or more of the following goals: prevalence, etiology, diagnosis, prediction, clinical course, management or treatment of alcohol abuse; alcoholism or alcohol-related health problems; consequences of alcoholism or alcohol abuse; and factors that relate to prevention of alcohol abuse, alcoholism, and other problems associated with alcohol consumption. The Alcohol Research Center grant provides a mechanism for fostering interdisciplinary cooperation in a group of established investigators conducting high-quality alcohol research. Therefore, existence of a strong research capability is fundamental to the establishment of a new center or the continuation of an existing center. A center should be an identifiable organizational unit within an institutional or organizational structure such as a university, medical center, or a consortium of affiliated cooperating institutions. SPECIAL REQUIREMENTS A. Definitions 1. Administrative Core Component A center should promote synergistic interaction of broad and diverse elements that require clearly specified lines of authority and accountability by appropriate institutional officials. The purpose of the administrative core component is to provide the organizational framework for the management, direction, and coordination of the center. The administrative core component must be managed by the Center Director or Scientific Director and may include funds for scientific enrichment activities such as special lectures, visiting scientists, symposia, seminars, and workshops; and for education and research dissemination activities for the public. 2. Scientific Core Components Core components for this RFA are defined as shared research resources that enhance productivity or in other ways assist a group of investigators working in alcohol-related research to accomplish the stated goals of the center. A core component is a laboratory, facility, service, or resource that interacts synergistically with research projects of the center. Research projects that use the core may be funded primarily from the center grant award (Specialized Research Center), from other support mechanisms such as Research Project Grants, Program Projects, or a combination thereof. Core components should provide investigators with some technique, instrumentation, service, or resource in a way that will enhance research progress and contribute to effectiveness. Each core component is directed by an investigator with established expertise relative to the support or service to be provided, usually a faculty-level individual. Some examples of research support that core components typically provide are: (1) technology that lends itself to automation or large batch preparation; (2) tissue and/or cell culture facilities; (3) complex instrumentation, e.g., electron microscopy, mass spectrometry, electrophysiology; (4) animal care and preparation; (5) service and training; (6) patient coordination; and (7) information processing, data management, and statistical services. 3. Research Components Research components are individual, scientifically meritorious, research projects that are interrelated within the overall center program so that the components contribute collectively to the goals of the center program to a greater extent than if each project were pursued separately. Each research component must be a highly focussed project under the direction of a component director who may also be the Center Director. The component director should be an established researcher of independent and scientifically recognized standing who is responsible for the scientific direction and conduct of the individual research component. 4. Pilot Project Component The purpose of pilot projects is to provide the center with a flexible means to develop and explore new research activities or directions, and unique scientific opportunities that could evolve into independently funded research projects. These funds are not intended to supplement ongoing research projects. Pilot projects should be in a separate pilot project core component that incorporates all of the pilot studies of the proposed center grant. B. General Requirements Details for preparing the application are provided in the supplemental instructions (see INQUIRIES below). Center grant applications should be logically organized into discrete components that comprise a proposed program of research. Each component is either a research component or a core component for which a separate detailed budget is included in the application. The application must include an administrative core and at least three research components, and may also include shared resource cores and/or a pilot project core component. A maximum and minimum number of components that will be accepted for center grant applications has been established. The minimum acceptable combined number of research components and core components is four (three of which must be research components). The maximum combined number of research components and core components, including any pilot project core component, is 10 for the total project period. The research plan for each core component and each research component is limited to 25 pages. Pages not used for one component may not be used to extend the page limit of other components/cores. These page limits do not apply to pilot projects. For pilot project requirements, see the section entitled "Pilot Project Component," (below). 1. Administrative Core Component The administrative core component will play a key role in the coordination and operation of the center. This core should be described in sufficient detail to assure that all proposed components and related activities will function optimally. An important function of this core is the administration of the budget. Through this component, the Center Director provides substantive leadership and manages the administrative core component. This component may also include the costs of scientific enrichment, education, and information dissemination activities. The administrative core should also provide integration of center functions. 2. Scientific Core Components Each shared resource component should be clearly described in terms of the services/resources to be provided to investigators. The description should include a discussion of the core's contributions to the research objectives of the Center. Relevant aspects of cost effectiveness, time saving, and increased efficiency attributable to the existence of the cores should also be addressed. A core component may support center grant research components and separately funded research project grants that are related to the center's theme. Each separately funded research project associated with the Center and utilizing core facilities should have a two-page description that includes its research objectives and how the center's core facility will impact upon it. The minimum number of research components/projects supported by a core component is two. A core component director who has acknowledged experience and scientific expertise relative to the purpose of the core must be designated for each core. This person should be an established scientist in his or her field. The description of the organization and mode of operation of the shared resource core should include discussion of quality control for the service or resource, and the procedures for evaluating and selecting projects eligible for use of the facility. Training in complex techniques and methods should be described if they are functions in proposed cores. Core components are intended to enhance opportunities for investigators at the center to include new technologies that broaden their research initiatives. Research is an appropriate initiative of a core when it is directly related to improving the operation, function, quality, or utility of the core. In renewal applications, ongoing or completed core activity that has enhanced or facilitated research should be described. Past performance and accomplishments of cores should be described, as should the effect of services provided by cores on investigators' productivity. 3. Research Components For each proposed research component, a clear description of the major goals, objectives, and its integration with the other components in relation to the overall center program should be provided to include: - The question(s) to be addressed and the hypotheses to be tested by the proposed research should be highly focused and fully explained. - A discussion of the design and procedures should describe the strategies proposed to accomplish the specific aims of the project and innovative aspects of the approach. - A description of the resources and working arrangements required to implement and conduct the proposed research should be fully elaborated with particular attention devoted to a description of necessary resources, subjects, clinical populations, and tissue resources that will be involved in proposed studies. All proposed research components need not be ongoing at any one time, but may be phased in at different time points during the life of the proposed center grant. This aspect should receive careful attention in the application and individual component preparation. 4. Pilot Project Component Pilot projects should be adequately, though concisely described. Although the specific number of pilot projects to be proposed is at the discretion of the applicant, requested funding for pilot studies may not exceed $200,000 or 20 percent (whichever is larger) of the total direct cost budget proposed for any one year. All proposed pilot projects need not be ongoing at any one time, but may be phased in at different points during the life of the proposed center grant. It is also recognized that the relative priority or need for specific pilot projects may change over the course of time. Although the center's framework for management of pilot funds and the mechanism for operating the program are left to the discretion of the center, the application must provide specific information to enable adequate scientific review. The application must include: - A description of each proposed pilot study including its rationale, objectives, approach, investigators, and significance for the center. The research description of any individual pilot project may not exceed 8 pages; the entire narrative for this Pilot Project Component may not exceed 50 pages irrespective of the number of pilot projects proposed. - A full description of the management of the pilot project component including a description of the process to be followed by the Center Director in selecting new pilot projects, should a need arise to replace any of the pilots contained in the application. - For competing renewal applications, information should be provided on the past experience of the center in utilizing pilot funds to further the goals. The narrative should include an assessment of the overall benefits derived from the availability of pilot resources. See attached "Special Instructions" for information on pilot project description requirements. C. Renewal Applications A comprehensive progress report is required for competing continuation (renewal) applications. A statement must be included in the application regarding the progress made by the center as a whole in its development as a national or regional research resource. In addition, for each research component of the existing center grant, a succinct account of its published and unpublished results must be provided, indicating progress toward achieving aims regardless of whether the component has been submitted for renewal. More specific details are provided in the special instructions that are available from the contact listed under INQUIRIES. D. Facilities and Environment Applicants must demonstrate the availability of adequate laboratory, clinical, and office facilities needed to carry out the objectives of the proposed center program. Although not required, it is desirable for all centers to have a commitment for sufficient contiguous space so that the center has a high degree of cohesion and visibility. Reference facilities affording access to the relevant literature must be readily available. It is expected that such reference facilities will be the primary repository of additional reference materials that may be obtained through center funding. Relevant support services, including adequate data processing facilities, must also be readily accessible within or through the institution. Assurances of such support must be included with the application. E. Organization and Administration A center must be an identifiable organizational unit with an administrative structure and clear lines of authority that will facilitate coordination among center personnel to assure maximum accountability and efficiency in center operations. An applicant must designate an institutional official to serve as Principal Investigator for the center grant and as director of the center. The institutional appointment of this person must provide sufficient authority to allocate space, personnel, and other resources essential to the center. This individual must demonstrate ability to organize, administer, and direct the center. The director of the center will have responsibility for planning and coordination of the center program, preparation of the budget, and oversight of expenditures, staff appointments, space allocation, and other aspects of management and operation of the center. Overall program management, coordination, communication, progress assessment, and quality control are typically responsibilities of the director and are facilitated through the administrative core. The administrative core should be described in sufficient detail to assure that all proposed components and related activities will function optimally. In addition, day-to-day operations involving procurement, finances, personnel, planning, and budgeting should be detailed in the description of this core. The applicant may also designate a Scientific Director who will be responsible to the Center Director and provide direct supervision of the scientific and operational aspects of the research program. Such a person should be an individual who has established scientific credentials and who is capable of providing the leadership essential to the success of the research program. The Scientific Director will be responsible for assuring interaction and collaboration among scientists conducting research within the center to facilitate a concerted approach to the research goals of the Center. The Scientific Director also will be responsible for the direct monitoring of ongoing research and for identifying (with the assistance of colleagues) research activities to be expanded or decreased and needs for additional resources or reallocation of resources. Key professional staff, such as directors of individual research components and core components of the center, should have the necessary training/experience to assure that the objectives and goals of the proposed studies will be achieved. Such persons must be established investigators with proven track records. A Program Advisory Committee shall be established and chaired by the Center Director. Its membership, selected by the Center Director from individuals outside the center, should be composed of at least five members. Members should be persons of recognized scientific standing who are generally familiar with the center's activities and represent a cross section of disciplines that are relevant to the work of the proposed center. It shall be the responsibility of this Committee to review and make recommendations to the Center Director on the conduct of all activities of the center. F. Training Although the primary function of each center is the conduct of high-quality interdisciplinary research, an important component related to the center and its research efforts is the training of research and clinical personnel. The applicant institution must therefore demonstrate or give reasonable assurances that it has: (a) the capacity to train predoctoral and/or postdoctoral students for careers in alcohol research; (b) the capacity to conduct programs of continuing education in the center's designated research theme in the medical and health service fields. Although the center need not necessarily have formal training programs of its own, there must be specific provision for coordination between the center and the training programs of the applicant institution and/or affiliated institutions. Center grant funds may not be used to pay stipends or other trainee costs; however, center staff may participate in the development of training programs, and center resources may be made available for use of trainees. Relationship to NIAAA In view of the special significance of this program, close coordination and communication between the NIAAA staff and staff of the Alcohol Research Centers is intended. The NIAAA program official will have responsibility for maintaining liaison with appropriate center leadership, serving as resource consultant to the center program, and keeping NIAAA staff informed on progress and accomplishments of the Centers. In addition, the program official with other NIAAA staff and consultants will, from time to time, make on-site visits for purposes of program coordination and exchange of information. STUDY POPULATIONS SPECIAL INSTRUCTIONS FOR INCLUSION OF MINORITIES AND WOMEN AS SUBJECTS IN RESEARCH Applications for grants and cooperative agreements and proposals for contracts that involve human subjects are required to include minorities and both genders in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis should be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy applies to all research involving human subjects and human materials, and applies to males and females of all ages. If one gender and/or minorities are excluded or are inadequately represented in this research, particularly in proposed population-based studies, a clear compelling rationale for exclusion or inadequate representation should be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group, together with a rationale for its choice. In addition, gender and racial/ethnic issue should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. Applications are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH and ADAMHA recognize that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., American Indians, or Alaskan Natives, Asians or Pacific Islanders, Blacks, Hispanics). Investigators must provide the rationale for studies on single minority population groups. Applications for support of research involving human subjects must employ a study design with minority and/or gender representation (by age distribution, risk factors, incidence/prevalence, etc.) appropriate to the scientific objectives of the research. It is not an automatic requirement for the study design to provide statistical power to answer the questions posed for men and women and racial/ethnic groups separately; however, whenever there are scientific reasons to anticipate differences between men and women, and racial/ethnic groups, with regard to the hypothesis under investigation, applicants should include an evaluation of these gender and minority group differences in the proposed study. If adequate inclusion of one gender and/or minorities are impossible or inappropriate with respect to the purpose of the research, because of the health of the subjects, or other reasons, or if in the only study population available, there is a disproportionate representation on one gender or minority/majority group, the rationale for the study population must be well explained and justified. The NIH/ADAMHA funding components will not make awards of grants, cooperative agreements or contracts that do not comply with this policy. For research awards which are covered by this policy, awardees will report annually on enrollment of women and men, and on the race and ethnicity of subjects. LETTER OF INTENT Prospective applicants are asked to submit by October 1, 1992, a letter of intent that includes a descriptive title of the proposed research, the name, address, and telephone number of the Principal Investigator, the identities of other key personnel and participating institutions, and the number and title of the RFA in response to which the application is being submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information that it contains is helpful in planning for the review of applications. It allows NIAAA staff to estimate the potential review workload and to avoid possible conflict of interest in the review. Letter of intent are to sent to Dr. Ernestine Vanderveen at the address provided in INQUIRIES. APPLICATION PROCEDURES Applicants are to use the grant application form PHS 398 (rev. 9/91). The title and number of this RFA, Alcohol Research Center Grants, AA-92-03, must be typed in item number 2a on the face page of the PHS 398 application form. When using the PHS 398 application form to respond to an RFA, applicants must affix the RFA label available in the application kit to the bottom of the face page. Failure to use this label could result in delayed processing of the application, such that it may not reach the review committee in time for review. Application kits containing the necessary forms and instructions may be obtained from business offices or offices of sponsored research at most universities, colleges, medical schools, and other major research facilities. If such a source is not available, the following office may be contacted for the necessary application material: Centers Program National Institute on Alcohol Abuse and Alcoholism Division of Basic Research 5600 Fishers Lane, Room 16C-06 Rockville, MD 20857 Telephone: (301) 443-1273 The receipt date for applications is December 10, 1992. The signed original and four permanent legible copies of the application must be sent or delivered to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892 In addition, it is requested that one copy be sent to: National Institute of Alcohol Abuse and Alcoholism Office of Scientific Affairs Parklawn Building, Room 16C-20 5600 Fishers Lane Rockville, MD 20857 Applications received after the December 10, 1992, receipt date will be returned to the applicant without review. Applicants from institutions that have a General Clinical Research Center (GCRC) funded by the NIH National Center for Research Resources may wish to identify the GCRC as a resource for conducting the proposed research. In such a case, a letter of agreement from either the GCRC program director or Principal Investigator must be included with the application. REVIEW CONSIDERATIONS Each center application will be reviewed by a group of experts to evaluate the scientific and technical merit of the applications. Recommendations from this review will be presented to the National Advisory Council on Alcohol Abuse and Alcoholism to make a final recommendation to the Director, NIAAA. Grant awards will be made with a start date of December 1, 1993, or later. Review Criteria The initial review for scientific and technical merit of applications will emphasize two major aspects: (1) review of the center as an integrated research effort focused on a central theme, including the administrative core, and (2) the review of each research component and all other core components. The review will also include an assessment of the academic and physical environment and special considerations, e.g., compliance with human subject and animal welfare requirements, and compliance with policies concerning inclusion of women and minorities in clinical research study populations. 1. The Center as an Integrated Effort o The significance of the overall research goals and development of a well-defined central research theme. o Multidisciplinary scope of the center; its cohesiveness, coordination, and interrelation; and the synergistic potential among the center components and core units. o The stature, experience, and administrative competence of the Center Director; and his or her commitment and ability to devote substantial time and effort to the center. o The scientific ability of the Scientific Director and his or her professional experience and leadership. o The justification of the core components in terms of accomplishing the center objectives, and their usefulness to the research components and/or independently supported investigators who utilize the core services or facilities. o The scientific stature of the directors of the research project components and/or the core components, the extent to which each of the directors will contribute to overall center goals, and their commitment to the center. o Administrative arrangements and organizational structure of the administrative core to facilitate and monitor attainment of center objectives and maintain quality control of ongoing projects. These factors include: - plans for communication and cooperation among investigators involved in the center; - mechanisms for allocation of funds and core resources and selecting meritorious pilot projects; - quality control, oversight; - day-to-day management; long-term planning and periodic evaluation; - contractual and consortium arrangements; and - procedures for replacement of key persons, if necessary. o Appropriateness of the overall budget for the work proposed in the center. o Potential of the center to become or maintain itself as a regional and national resource, including capacity to provide quality research training, opportunities for independent research career development, and plans for research information dissemination and education activities. o In addition, applications for renewal support will be evaluated in terms of the degree to which the center has achieved stated goals with special attention to: - the scientific merit of completed research, - recruitment of new scientists into alcohol research, - development of a multidisciplinary research team, and - coalescence of the center staff into an effective team. 2. Individual Research Components and Core Components o The scientific and technical merit of each research component and each core component. o The significance of each research and core component and its relation to the central theme of the center. o Evidence of quality control of proposed core component's services, resources, facilities. o The qualifications, experience, and commitment of the component director responsible for the research component and/or core component, including his or her ability to devote adequate time and effort to the center. o The appropriateness of the budget request for each of the proposed research project components and/or core components, administrative core, and any pilot project core component. 3. Resources and Environment In addition to the scientific components, e.g., research project and core components, the initial review group will also evaluate: o The academic and physical environment in which the research will be conducted, including availability of space, equipment, research subjects and materials, and the potential for interaction with scientists from other departments and other institutions. o The institutional strength, stability, commitment to research and support for the center, including fiscal responsibility and management capability to assist the Center Director and staff in complying with HHS, PHS, and ADAMHA policies. o Opportunities for research training and education for persons from various disciplines and professions. 4. Other Considerations o When an application proposes research or research-related activity that involves potential risks to human subjects, animals, and/or the environment, the adequacy of the proposed means for protecting against such risks must be demonstrated for each component. o Specific statements addressing compliance with ADAMHA policies on inclusion of women and minorities in studies involving human subjects. AWARD CRITERIA Applications recommended by the NIAAA National Advisory Council will be considered for funding on the basis of the overall merit of the application as well as such considerations as program balance, relevance to the mission and goals of the NIAAA, research program priorities, equitable geographic distribution, continuity of support, and availability of funds. Awards will be made for up to five-year project periods with separate fiscal awards made annually. INQUIRIES For a copy of the supplemental instructions and preapplication consultation contact: Dr. Ernestine Vanderveen Associate Director Division of Basic Research National Institute on Alcohol Abuse and Alcoholism 5600 Fishers Lane, Room 16C-06 Rockville, MD 20857 Telephone: (301) 443-1273 Director inquiries relating to fiscal matters to: Mr. Edward Ellis Grants Management Specialist Grants Management Branch National Institute on Alcohol Abuse and Alcoholism 5600 Fishers Lane, Room 16-86 Rockville, MD 20857 Telephone: (301) 443-4703 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.891. The statutory authorities for awards under this RFA are Sections 301 and 511 of the Public Health Service Act (42 USC 241 and 290bb-1). Federal Regulations at 42 CRF Part 54a, Subpart E "Grants for National Alcohol Research Centers" apply to grants under this RFA. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. .
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