BIOENGINEERING RESEARCH PARTNERSHIPS

Release Date: October 29, 1998

PA NUMBER:  PAS-99-010

P.T.

National Cancer Institute
National Center for Research Resources
National Eye Institute
National Human Genome Research Institute
National Heart, Lung, and Blood Institute
National Institute on Aging
National Institute on Alcohol Abuse and Alcoholism
National Institute of Allergy and Infectious Diseases
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Institute of Child Health and Human Development
National Institute on Drug Abuse
National Institute on Deafness and Other Communication Disorders
National Institute of Dental Research
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Environmental Health Sciences
National Institute of General Medical Sciences
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke
National Institute of Nursing Research
National Library of Medicine

Letter of Intent Receipt Date:  February 19, 1999 (and annually thereafter to be
announced)
Application Receipt Date:  March 26, 1999 (and annually thereafter to be
announced)

PURPOSE

Participating Institutes and Centers (ICs) of the National Institutes of Health
(NIH) invite applications for R24 awards to support Bioengineering Research
Partnerships (BRPs) to support basic bioengineering research addressing important
biological or medical research problems.  A BRP is a multidisciplinary research
team applying an integrative, systems approach to developing knowledge and/or
methods to prevent, detect, diagnose, and treat disease and understand health and
behavior, and must include bioengineering expertise in combination with basic
and/or clinical investigators.  A BRP may propose design-directed or hypotheses-
driven research in universities, national laboratories, medical schools, private
industry and other public and private entities.

In parallel with this program announcement (PA), NIH is issuing a PA for
Bioengineering Research Grants (BRGs).  BRG applications differ from BRP
applications in that they will be funded as R01 awards, with the research
generally to be performed in a single laboratory or involving a small number of
investigators.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health promotion
and disease prevention objectives of "Healthy People 2000," a PHS-led national
activity for setting priority areas. This PA, Bioengineering Research
Partnerships (BRP), is related to all priority areas.  Potential applicants may
obtain a copy of "Healthy People 2000" (Full Report:  Stock No. 017-001-00474-0
or Summary Report:  Stock No. 017-001-00473-1) through the Superintendent of
Documents, Government Printing Office, Washington, DC 20402-9325 (Tel:
202-512-1800).

ELIGIBILITY REQUIREMENTS

Applications may be submitted by domestic for-profit and non-profit
organizations, public and private, such as universities, colleges, hospitals,
laboratories, units of State and local governments, and eligible agencies of the
Federal government.  Foreign institutions are not eligible to apply, but BRP
collaborative projects may include work at a foreign site when the expertise at
the foreign site is not present in the United States.  Racial/ethnic minority
individuals, women, and persons with disabilities are encouraged to apply as
principal investigators.

MECHANISM OF SUPPORT

The mechanism of support will be the resource-related research project (R24).
Responsibility for the planning, direction, and execution of the proposed project
will be solely that of the applicant.  The total requested project period may not
exceed five years.

An applicant planning to submit an application requesting $500,000 or more in
direct costs for any year is advised that he or she must contact IC program
staff, listed under INQUIRIES, before submitting the application, i.e., as plans
for the study are being developed.  Furthermore, the applicant must obtain
agreement from IC staff that the IC will accept the application for consideration
for award.  Finally, the applicant must identify, in a cover letter sent with the
application, the staff member and IC who agreed to accept assignment of the
application.  This policy requires an applicant to obtain agreement for
acceptance of both any such application and any subsequent amendment.  Refer to
the NIH Guide for Grants and Contracts, March 20, 1998
(http://www.nih.gov/grants/guide/notice-files/not98-030.html).

FUNDS AVAILABLE

The estimated total funds (direct and indirect costs) available in FY 2000 for
the first year of support for awards under this PA will be approximately $12
million.  Because the nature and scope of the research proposed in response to
this PA may vary, it is anticipated that the size of the awards will vary also. 
The number of awards and level of support will depend upon receipt of a
sufficient number of applications of high scientific merit.  Although this PA is
provided for in the financial plans of the participating ICs, awards pursuant to
this PA are contingent upon the availability of funds. Funding beyond the first
and subsequent years of the grant will be contingent upon satisfactory progress
during the preceding years and the availability of funds.  Applicants are
encouraged to discuss budget requests with program staff listed under INQUIRIES
prior to submission.  The initial period of support for a BRP award may be up to
five years.  The award may be competitively renewed for a second period (up to
five years) based on peer review of a renewal application.  NIH does not envision
more than one renewal period.

RESEARCH OBJECTIVES

Background

Many of today's biological problems are too complex to be solved by biologists
alone; partners are needed in many disciplines, including physics, mathematics,
chemistry, computer sciences, and engineering.  Bioengineering integrates
principles from a diversity of fields.  The creativity of interdisciplinary teams
is resulting in new basic understanding, novel products and innovative
technologies.  Bioengineering also crosses the boundaries of academia, science,
medicine, and industry.

Recognizing the increasing importance of bioengineering in public health, the NIH
established the Bioengineering Consortium (BECON) as a central focus for NIH
bioengineering research.  BECON held a two-day Bioengineering Symposium on
February 27-28, 1998.  A summary of the presentations and the conclusions of the
panels are included in the full report, which is available on the Internet at
http://www.nibib.nih.gov/.  The discussions and recommendations
of symposium participants aided in the formulation of the BRP and BRG PAs.

For example, both the BRP and BRG PAs recognize that applications for
bioengineering projects are often focused on technology development rather than
on proving or disproving a scientific hypothesis.  Therefore, the NIH review
criteria for bioengineering proposals submitted in response to these PAs have
been modified to ensure that these proposals are evaluated appropriately and
fairly.

Objective and Scope

The objective of this program announcement is to encourage research in selected
basic bioengineering areas.  Bioengineering is defined as follows: Bioengineering
integrates physical, chemical, or mathematical sciences and engineering
principles for the study of biology, medicine, behavior, or health.  It advances
fundamental concepts, creates knowledge from the molecular to the organ systems
level, and develops innovative biologics, materials, processes, implants,
devices, and informatics approaches for the prevention, diagnosis, and treatment
of disease, for patient rehabilitation, and for improving health.

Each BRP should bring together the necessary engineering, basic science and/or
clinical expertise to focus on a significant area of bioengineering research
within the mission of the NIH. A BRP can vary in size and exhibit diverse forms
of organization, participation, and operation.  No single type of BRP fits the
needs of every area.  Rather, the size, structure, and operation of a BRP are
determined by the proposed research.

Areas of Bioengineering Research for a BRP.

Applications for BRP awards should focus on an area of bioengineering research
where progress is likely to make a significant contribution to improving human
health.  It is likely that these areas will be of interest to many ICs.  For
example, materials science may be relevant to the ultimate development of
artificial organs or novel medical implants; thus a research initiative in
materials science would be of interest to many ICs, even though it is not clear
at the outset which organ or which IC will benefit from advances in the field. 
Similarly, bioinformatics may provide analysis and modeling tools for large sets
of biological data, facilitate home-based devices, and create networks to help
manage chronic diseases.  Imaging may be applied to the monitoring of cellular
processes, elucidation of developmental processes in the organism, identification
and localization of disease or its progression, development of virtual reality
training tools, and monitoring of therapeutic interventions.  Micro- and nano-
fabrication and fluidics may be applied to creating in vivo sensors, biochemical
analysis systems, imaging systems, and surgical devices.

Bioengineering areas of particular relevance to the mission of ICs are identified
below.  The topics listed are not intended to be exclusive.

Bioengineering Research Areas

o  Biomechanics
o  Bioprocessing
o  Bioelectrics, Ion Channels, and Organ Function
o  Clinical Medicine, Therapeutics & Drug Delivery
o  Combinatorial Approaches to Chemistry, Materials, Genes, and Therapeutics
o  Functional Genomics including Microarray Technology, Integrated Systems, and
Analysis Tools
o  Imaging
o  Nanotechnology
o  Informatics and Computational Methods
o  Medical Implants, Biomembranes, Sensors and Devices
o  Complex Biological Systems
o  Organ Culture Systems and Organogenesis
o  Rehabilitation, Prostheses
o  Cell and Tissue Engineering and Biomaterials
o  Tissue Regeneration
o  Integrative Physiology
o  Drug Bioavailability

Organizational Structure

BRP Leadership and Management

The BRP Principal Investigator is responsible for management, staffing, and
resource allocation and for administering the award in accordance with NIH
policies.  The PI has both the responsibility and authority to use BRP funds in
the most productive way to achieve the goals proposed in the application.  To
accomplish this task, the PI should adjust BRP funding among BRP participants,
supporting new Partners or reducing support to old Partners as needed.  The PI's
administrative structure will depend upon the size and scope of the proposed
research.  For example, there may be less involvement of a clinical component in
the early stages of a BRP and far more when the issue of clinical application is
more salient.

Annual BRP PI Meeting.

BRP PIs will meet annually to share substantive results, to ensure that the NIH
has a coherent view of the advances in these fields, and to have an opportunity
for collective problem solving among the BRPs.  The cost of participating in the
BRP PI annual meeting should be built into the BRP budget.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of the NIH that women and members of minority groups and their
sub-populations must be included in all NIH supported medical and behavioral
research projects involving human subjects, unless a clear and compelling
rationale and justification are provided that inclusion is inappropriate with
respect to the health of the subjects of the purpose of the research.  This
policy results from the NIH Revitalization Act of 1993 (Section 492B of Public
Law 103-43).

All investigators proposing research involving human subjects should read the
"NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical
Research," which have been published in the Federal Register of March 28, 1994
(FR 59 14508-14513) and the NIH Guide for Grants and Contracts, Vol. 23, No. 11,
March 18, 1994
(http://www.nih.gov/grants/guide/1994/94.03.18/notice-nih-guideline008.html).

Investigators may obtain copies from these sources or from the program staff
listed under INQUIRIES.  Program staff may also provide additional relevant
information concerning the policy.

NIH POLICY AND GUIDELINES ON THE INCLUSION OF CHILDREN AS PARTICIPANTS IN
RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research, conducted or supported by the
NIH, unless there are scientific and ethical reasons not to include them. This
policy applies to all initial (Type 1) applications submitted for receipt dates
after October 1, 1998.

All investigators proposing research involving human subjects should read the
"NIH Policy and Guidelines on the Inclusion of Children as Participants in
Research Involving Human Subjects" that was published in the NIH Guide for Grants
and Contracts, March 6, 1998, and is available at the following URL address:
http://www.nih.gov/grants/guide/notice-files/not98-024.html.

Investigators may obtain copies from these sources or from the Program Contact
person listed under INQUIRIES who may also provide additional relevant
information concerning the policy.

LETTER OF INTENT

Prospective applicants are requested to submit, by February 19, 1999, a letter
of intent that includes a descriptive title of the proposed research, the name,
address, and telephone of the principal investigator and collaborators, and the
number and title of this PA.  Although a letter of intent is not required, is not
binding, and does not enter into the review if a subsequent application, the
information that it contains allows NIH staff to estimate the potential review
workload and avoid conflict of interest in the review.

The letter of intent is to be sent to:

Suzanne Fisher, Ph.D.
Division of Receipt Referral
Center for Scientific Review
6701 Rockledge Drive, Suite 2030, MSC 7720
Bethesda, MD  20892-7720

APPLICATION PROCEDURES

Applicants are strongly advised to contact IC program staff listed under
INQUIRIES to discuss the responsiveness of their plans before developing a
detailed research proposal.  Since a BRP award may include funds from a single
IC or from several NIH ICs, applicants may be directed to contact IC program
staff in more than one IC.  The use of e-mail for such communication is strongly
recommended.  Applicants should identify in a cover letter the IC(s) that has
agreed to accept the application for funding consideration.  In addition, a
description of the relevance of the proposed research to the mission of each IC
that might support the project should be included in the "Specific Aims" and
"Significance" sections of the application.

Applications are to be submitted on the grant application form PHS 398 (rev.
5/95) and will be accepted only once each year, on the annual receipt date.
Application kits are available at most institutional offices of sponsored
research and may be obtained from the Division of Extramural Outreach and
Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC
7910, Bethesda, MD 20892-7910, Telephone: (301) 435-0714, E-mail:
grantsinfo@nih.gov.  Application kits are also available on the Internet at
http://www.nih.gov/grants/funding/funding.htm

Follow the PHS 398 instructions for "Preparing Your Application" with
modifications and additions as described in the sections below.

Page limitations.  Page limitations have been increased from the normal 25 page
limit for sections A-D of the "Research Plan" of an application. For applications
in response to this program announcement, the page limitation is a maximum of 40
pages for sections A-D.  This 40 page limit is an absolute maximum and applicants
are encouraged to be concise and use fewer pages.

Title and Abstract.  Title the application the same as the title of the BRP.
Identify the institution leading the BRP and any other participating
institutions. The abstract should provide clear descriptions of the area of
bioengineering research that will be the focus of the BRP, the planned
multidisciplinary approach, and the specific milestones to be achieved and
timelines for achievement for the first year and additional years of the grant.

BRP BUDGET ITEMS

Proposed Budget Organization.  Include a separate budget for each Partner at a
non-grantee institution, and when appropriate for clarity, for each Partner
within the grantee institution.  Include a summary budget for all BRP
participants with Partners at non-grantee institutions shown as consultants or
consortium arrangements.

Maximum Cost and Annual Rate of Inflation.  The NIH ICs will not provide annual
support in excess of $2 million total cost for the first year.  Requests for
succeeding years in excess of $2 million plus inflationary increases must be
thoroughly justified in the application.

Personnel.  Percent Effort - The PI is expected to devote a minimum of 25% effort
to the BRP.  The percent effort requested for other personnel should be limited
to time devoted specifically to BRP Partner activities and not to other research
activities.  Information documenting the level of effort on BRP activities should
be included in the application.  The need for all requested personnel costs
should be thoroughly justified.  The percent effort of the BRP PI should be
justified in the context of the PI's other responsibilities. Administrative
support (a secretary or an administrative assistant) may be requested for the BRP
office only for matters directly pertaining to the BRP.

Travel.  BRP PI meeting(s) - There will be an annual BRP PI meeting at a location
to be determined by NIH staff.  The PI meeting will be held at NIH, at a BRP
site, or at the site of a scientific conference that many of the PIs plan to
attend.  The BRP PI and at least one other BRP scientist should attend the annual
meeting.  Additional BRP members are welcome.  Applicants should include travel
funds specifically for these meetings in the BRP budget request.  For budget
purposes, applicants may assume that total annual costs to the grant for the BRP
PIs meeting will not exceed $2500.

Other Travel - Applicants may request and justify travel funds in addition to the
funds required for the Annual PI Meeting.  Travel funds could be used to promote
collaboration among BRP partners at different institutions or at a distant site,
be used for travel of external advisors to the BRP site, and/or be used for BRP
Partners to attend scientific meetings essential to the progress of the BRP and
for which other funds are not available.

Other Expenses.  This category includes the costs necessary for the central
administration and fiscal management of the BRP, including relevant and
reasonable costs for reprints, graphics, and publications.

Projected Funding by Source.  Some BRP applicants may anticipate or receive
commitments for significant funding from other than NIH sources, e.g., from a
collaborating company. When this is the case, applications should describe the
source, annual amount and use of other funding.

BIOGRAPHICAL SKETCHES
For the Principal Investigator, Co-Investigator(s), and non Co-Investigator
Senior Personnel, provide a brief biographical sketch or curriculum vitae,
including a list of the five most recent or significant publications. This
section must not exceed two pages per person.

OTHER SUPPORT
Provide a complete listing of current and pending support for the Principal
Investigator, Co-Investigator(s), and non Co-Investigator Senior Personnel only.

RESOURCES

Facilities and Equipment.  Describe the equipment and facilities available to the
proposed BRP.

Institutional commitment.  If the BRP implies an institutional commitment of
resources across boundaries in the institution or anticipates the provision of
institutional resources, please include letters from relevant senior level
individuals describing those commitments.

Shared Experimental Facilities.  Where appropriate, describe the shared
facilities to be established, including specific major research instrumentation,
and plans for the development of instrumentation.  Describe plans for maintaining
and operating the facilities, including staffing, provisions for user fees, and
plans for ensuring access to outside users.  Distinguish between existing
facilities and those still to be developed.

RESEARCH PLAN

A.  Specific Aims.  Describe the specific aims in the selected area of
bioengineering research and the goals for the first year and for the long term.
Delineate the design principle(s) supporting the research or the hypothesis(-es)
to be tested.  Describe the expected applications of the bioengineering research
that will improve human health. One page is recommended.

B.  Background and Significance.  Briefly describe the area of bioengineering
research that is the focus of the BRP.  Critically evaluate existing knowledge
and approaches that have been or are being directed in the area, and specifically
describe how the BRP approach will advance the field.  State concisely the
importance and health relevance of the proposed research to the Specific Aims.

C.  Preliminary Studies and Rationale.  Preliminary studies are not required for
BRP applications, but applicants with preliminary results should describe them.
In the absence of preliminary results, applicants should describe the rationale
and scientific and engineering bases for the proposal.

D.  Research Design and Methods.  A BRP should focus on a systems approach in a
significant area of bioengineering research.  Describe an overall research plan
that is sufficiently long term (5-10 years) to justify a BRP organization and
adaptable enough to permit change as the research proceeds.  Clearly indicate
current activities, why a BRP is necessary, and what unique opportunities will
be provided by the proposed BRP.  Explain the integrative-engineering approach
and why such an approach is essential to the proposed research.  If the proposed
BRP research is closely related to ongoing research or an existing Center,
explain how the research activities of the BRP will complement but not overlap
with existing research.  Describe the efforts of each Partner and how these will
be integrated and organized to accomplish the specific aims of the project. 
Provide a tentative sequence or timetable for the project.  Include how the data
will be collected, analyzed, and interpreted.  Describe how the data and
technological advances will be disseminated to other investigators, and if
relevant, how the technology information (intellectual property) will be
transferred to the commercial sector for product development.

The title and number of this program announcement must be typed on line 2 of the
face page of the application form and the YES box must be marked.

Submit a signed, typewritten original of the application, including the
Checklist, and appendices, and five signed photocopies in one package to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

REVIEW CONSIDERATIONS

Upon receipt, applications will be reviewed for completeness by the NIH Center
for Scientific Review (CSR), and for responsiveness by program staff of the IC
to which an application is assigned.  Incomplete and/or non-responsive
applications will be returned to the applicant without further consideration. 
Applications that are complete and responsive will be evaluated for scientific
and technical merit by Scientific Review Groups (SRGs) of CSR.  As part of the
initial merit review, applications may be subjected to standard NIH streamlined
review procedures; nevertheless, each application will receive a written
critique.

Review Criteria

The NIH review criteria have been adapted to ensure that the BRP application is
evaluated appropriately.  The score should reflect the overall impact that the
BRP award could have on the selected area of bioengineering research based on
consideration of the five criteria, with the emphasis on each criterion varying
from one application to another, depending on the nature of the application and
its relative strengths.  Note that an application need not be strong in all
categories to be judged likely to have major scientific impact and thus deserve
a high priority score.  For example, an investigator may propose to carry out
important work that by its nature is not innovative but is essential to move a
field forward.  The review criteria follow:

(1) Significance.  If the Specific Aims of the BRP are achieved, will they
provide significant advances in the selected area of bioengineering research? Is
the research likely to have a significant impact on other areas of research? Will
the technological advances have a significant impact on human health?

(2) Approach.  Are the BRP engineering, scientific and clinical approaches and
methods adequately developed, well integrated, and appropriate to the aims of the
project?  Does the applicant acknowledge potential problem areas and consider
alternative tactics?  Are the milestones and evaluation procedures appropriate? 
Are the plans for information dissemination and technology transfer reasonable?

(3) Innovation.  Does the BRP propose new approaches or explore new research
paradigms or new concepts that combine engineering, basic and clinical sciences? 
Are extant approaches or concepts applied to new scientific problems in novel
ways?

(4) Investigators.  Is the PI capable of coordinating and managing the proposed
BRP?  Are the investigators (Partners) appropriately trained in their disciplines
and well suited to carry out the proposed work?  Is there evidence that the
Partners can work together effectively?  Do the advantages of a Partner at a
distant site outweigh the disadvantages?

(5) Environment.  Does the scientific and technological environment in which the
work will be done contribute to the probability of success?  Does the proposed
research take advantage of unique features of the scientific environment or
employ useful collaborative arrangements?  Is there evidence of institutional
support?

In addition to these five review criteria, applicants must demonstrate adequate
provisions for the protection of human and animal subjects, the safety of the
research environment, and conformance with the "NIH Guidelines for the Inclusion
of Women and Minorities as Subjects in Clinical Research," and "NIH Policy and
Guidelines on the Inclusion of Children as Participants in Research Involving
Human Subjects."

AWARD CRITERIA

BRP applications will compete for available funds with all other approved
applications. The following will be considered in making funding decisions:

o  Quality of the proposed research as determined by peer review
o  Availability of funds
o  Institute's priority for area of proposed research

INQUIRIES

The opportunity to clarify any issues or questions regarding a BRP or a BRP
application is welcome.  

Questions regarding BRP scientific issues, management issues, or issues on cores
related to participating ICs may be directed to:

NCI
Carol Dahl, Ph.D.
National Cancer Institute
Building 31, Room 11A03, MSC 2590
Bethesda, MD  20892-2590
Telephone:  (301) 496-1550
FAX:  (301) 496-7807
Email:  carol_dahl@nih.gov

NCRR
Richard Dubois, Ph.D.
Biomedical Technology
National Center for Research Resources
6705 Rockledge Drive, Room 61060, MSC 7965
Bethesda, MD  20892-7965
Telephone:  (301) 435-0755
FAX:  (301) 480-3659
Email:  rickard@ncrr.nih.gov

NEI
Lore Anne McNicol, Ph.D.
National Eye Institute
6120 Executive Boulevard, Suite 350, MSC 7164
Bethesda, MD  20892-7164
Telephone:  (301) 496-5301
FAX:  (301) 402-0528
Email:  loreanne.mcnicol@nei.nih.gov

NHGRI
Jeffery A. Schloss, Ph.D.
Division of Extramural Research
National Human Genome Research Institute
Building 38A, Room 614, MSC 7531
Bethesda, MD  20892-6050
Telephone:  (301) 496-7531
FAX:  (301) 480-2770
Email:  jeff_schloss@nih.gov

NHLBI
John T. Watson, Ph.D.
Acting Deputy Director
National Heart, Lung, and Blood Institute
9000 Rockville Pike, Room 5A49
Bethesda, MD  20892
Telephone:  (301) 496-1078
FAX:  (301) 402-3686
Email:  jw53f@nih.gov

NIA
Evan Hadley, M.D.
Geriatrics
National Institute on Aging
Gateway Building, Suite 3E327, MSC 9205
Bethesda, MD  20892-9205
Telephone:  (301) 435-3044
FAX:  (301) 402-1784
Email:  hadleye@exmur.nia.nih.gov

NIAAA
Jules Selden, D.V.M., Ph.D.
Division of Basic Research
National Institute on Alcohol Abuse and Alcoholism
6000 Executive Boulevard, Suite 402, MSC 7003
Bethesda, MD  20892-7003
Telephone:  (301) 443-2678
FAX:  (301) 594-0673
Email:  js365c@nih.gov

NIAID
Vicki Seyfert, Ph.D.
National Institute of Allergy and Infectious Diseases
6003 Executive Boulevard, Room 4A21
Rockville, MD  20852
Telephone:  (301) 496-7551
FAX:  (301) 402-2571
Email:  vs62y@nih.gov

NIAMS
James S. Panagis, M.D., M.P.H.
Musculoskeletal Diseases Branch
National Institute of Arthritis and Musculoskeletal and Skin Diseases
6500 Center Drive, Room 5AS-37K
Bethesda, MD  20892-6500
Telephone:  (301) 594-5055
FAX:  (301) 480-4543
Email:  jp149d@nih.gov

NICHD
Louis A. Quatrano, Ph.D.
National Center for Medical Rehabilitation Research
National Institute of Child Health and Human Development
Building 61E, Room 2A03
Bethesda, MD  20892-7510
Telephone:  (301) 402-2242
FAX:  (301) 402-0832
Email:  quatranl@hd01.nichd.nih.gov

NIDA
Thomas G. Aigner, Ph.D.
Division of Basic Research
National Institute on Drug Abuse
Parklawn Building, Room 10A-19
Rockville, MD  20857
Telephone:  (301) 443-6975
FAX:  (301) 594-6443
Email:  ta17r@nih.gov

NIDCD
Lynn E. Huerta, Ph.D.
Division of Human Communication
National Institute on Deafness and Other Communication Disorders
6120 Executive Boulevard, Room 400-C, MSC 7180
Bethesda, MD 20892-7180
Telephone:  (301) 402-3458
FAX:  (301) 402-6251
Email:  Lynn_Huerta@nih.gov

NIDDK
Joan T. Harmon, Ph.D.
Division of Diabetes, Endocrinology, and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
45 CENTER DRIVE, Room 5AN-18G MSC 6600
BETHESDA, MD 20892-6600
Telephone:  (301) 594-8808
FAX:  (301) 480-3503
E-mail:  HarmonJ@extra.niddk.nih

NIDR
Eleni Kousvelari
Division of Extramural Research
National Institute of Dental Research
Natcher Building, Room 4AN 18A, MSC 6402
Bethesda, MD 20892-6402
Telephone:  (301) 594-2427
FAX:  (301) 480-8318
Email:  kousvelari@de45.nidr.nih.gov

NIEHS
Jose Velazquez, Ph.D.
Division of Extramural Research Training
National Institute for Environmental Health Sciences
P.O. Box 12233, MSC EC-21
Research Triangle Park, NC  27709
Telephone:  (919) 541-4998
FAX:  (919) 541-2860
Email:  velazqu1@niehs.nih.gov

NIGMS
Warren Jones, Ph.D.
Division of Pharmacology, Physiology and Biological Chemistry
National Institute of General Medical Sciences
45 Center Drive, Room 2AS-43H, MSC 6200
Bethesda, MD  20892-6200
Telephone:  (301) 594-5938
FAX:  (301) 480-2802
Email:  jonesw@nigms.nih.gov

NIMH
Michael F. Huerta, Ph.D.
Division of Basic and Clinical Neuroscience Research
National Institute of Mental Health
Parklawn Building, Room 11-103
Rockville, MD  20857
Telephone:  (301) 443-3563
FAX:  (301) 443-1731
Email:  mhuerta@helix.nih.gov

NINDS
William Heetderks, M.D., Ph.D.
Division of Stroke, Trauma, and Neurodegenerative Disorders
National Institute of Neurological Disorders and Stroke
Federal Building, Room 8A13
Bethesda, MD  20892-9155
Telephone:  (301) 496-9155
FAX:  (301) 402-1501
Email:  Heet@nih.gov

NINR
Hilary D. Sigmon, Ph.D., RN
Division of Extramural Activities
National Institute of Nursing Research
45 Center Drive, Room 3AN12, MSC 6300
Bethesda, MD  20892-6300
Telephone:  (301) 594-5970
FAX:  (301) 480-8260
Email:  hilary_sigmon@nih.gov

NLM
Peter Clepper
Program Officer
National Library of Medicine
6705 Rockledge Drive, Suite 301
Bethesda, MD  20871
Telephone:  (301) 594-4882
FAX:  (301) 402-2952
Email:  clepper@nlm.nih.gov

Questions on review issues may be directed to:

CSR
Richard Panniers, Ph.D.
Scientific Review Administrator
Center for Scientific Review
6701 Rockledge Drive, Room 5148
Bethesda, MD  20892
Telephone:  (301) 435-1741
FAX:  (301) 480-2241
Email:  pannierr@drg.nih.gov

Questions on fiscal issues may be directed to:

NCI
Bill Wells
Grants Administration Branch
National Cancer Institute
6120 Executive Boulevard, Room 243, MSC 7150
Bethesda, MD  20892-7150
Telephone:  (301) 496-7800
FAX:  (301) 496-8601
Email:  wellsw@gab.nci.nih.gov

NCRR
Joellen Harper
Office of Grants Management
National Center for Research Resources
6705 Rockledge Drive, Room 6086, MSC 7965
Bethesda, MD  20892-7965
Telephone:  (301) 435-0836
FAX:  (301) 402-1951
Email:  harperj@ncrr.nih.gov

NEI
Carolyn E. Grimes
Grants Management Officer
National Eye Institute
6120 Executive Boulevard, Suite 350, MSC 7164
Bethesda, MD  20892-7164
Telephone:  (301) 496-5884
FAX:  (301) 402-0528
Email:  cegrimes@nei.nih.gov

NHGRI
Jean Cahill
Grants Management Officer
National Human Genome Research Institute
Building 38A, Room 613, MSC 6050
Bethesda, MD 20892-6050
Telephone:  (301) 402-0733
FAX:  (301) 402-1951
Email:  jean_cahill@nih.gov

NHLBI
William Darby
Grants Management Officer
National Heart, Lung, and Blood Institute
6701 Rockledge Drive, Suite 7128
Bethesda, MD  20892
Telephone:  (301) 435-0177
FAX:  (301) 480-3310
Email:  wd8u@nih.gov

NIA
Joseph Ellis
Grants and Contracts Management Officer
National Institute on Aging
Gateway Building, Suite 2N212
Bethesda, MD  20892
Telephone:  (301) 496-1472
FAX:  (301) 402-3672
Email:  ellisj@exmur.nia.nih.gov

NIAAA
Linda Hilley
Grants Management Officer
National Institute on Alcohol Abuse and Alcoholism
6000 Executive Boulevard, Suite 504
Bethesda, MD  20892-7003
Telephone:  (301) 443-4704
FAX:  (301) 443-3891
Email:  lh67b@nih.gov

NIAID
Linda Shaw
Grants Management Branch
National Institute of Allergy and Infectious Diseases
6003 Executive Boulevard, Room 4B-31
Rockville, MD  20850
Telephone:  (301) 402-6611
FAX:  (301) 480-3780
Email:  ls15k@nih.gov

NIAMS
Irene Grissom
Grants Management Branch
National Institute of Arthritis and Musculoskeletal and Skin Diseases
6500 Center Drive, Room 5AS-43J
Bethesda, MD  20892-6500
Telephone:  (301) 594-3507
FAX:  (301) 480-5450
Email:  grissomi@mail.nih.gov

NICHD
Mary Ellen Colvin
Grants Management Branch
National Institute of Child Health and Human Development
Building 61E, Room 8A17
Bethesda, MD  20892-7510
Telephone:  (301) 496-1303
FAX:  (301) 402-0915
Email:  MC113B@nih.gov

NIDA
Gary Fleming, J.D., M.A.
Grants Management Branch
National Institute on Drug Abuse
5600 Fishers Lane
Rockville, MD  20857
Telephone:  (301) 443-6710
FAX:  (301) 594-6847
Email:  gf6s@nih.gov

NIDCD
Sharon Hunt
Grants Management Branch
National Institute on Deafness and Other Communication Disorders
6120 Executive Boulevard, Room 400-C, MSC 7180
Bethesda, MD  20892-7180
Telephone:  (301) 402-0909
FAX:  (301) 402-1758
Email:  sharon_hunt@nih.gov

NIDDK
Nancy Dixon
Grants Management Officer
National Institute of Diabetes and Digestive and Kidney Diseases
45 Center Drive, Room 6AS49K, MSC 6600
Bethesda, MD  20892-6600
Telephone:  (301) 594-8854
FAX:  (301) 480-4237
Email:  dixonn@extra.niddk.nih.gov

NIDR
Kevin Crist
Division of Extramural Research
National Institute of Dental Research
Natcher Building, Room 4AS 55
Bethesda, MD  20892-6402
Telephone:  (301) 594-4800
FAX:  (301) 480-8301
Email:  Kevin.Crist@nih.gov

NIEHS
David Mineo
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P.O. Box 12233, MSC EC-21
Research Triangle Park, NC  27709
Telephone:  (919) 541-1373
FAX:  (919) 541-2860
Email:  dm44x@nih.gov

NIGMS
Antoinette Holland
Grants Management Specialist
National Institute of General Medical Sciences
45 Center Drive, Room 2AN-50B, MSC 6200
Bethesda, MD  20892-6200
Telephone:  (301) 594-5132
FAX:  (301) 480-2554
Email:  hollanda@nigms.nih.gov

NIMH
Diana S. Trunnell
Grants Management Branch
National Institute of Mental Health
Parklawn Building, Room 7C-08
Rockville, MD  20857
Telephone:  (301) 443-2805
FAX:  (301) 443-6885
Email:  Diana_Trunnell@nih.gov

NINDS
Brenda Kibler
Grants Management Specialist
National Institute of Neurological Disorders and Stroke
Federal Building, Room 1004
Bethesda, MD  20892
Telephone:  (301) 496-9231
FAX:  (301) 402-0219
Email:  bk29j@nih.gov

NINR
Jeff Carow
Division of Extramural Activities
National Institute of Nursing Research
45 Center Drive, Room 3AN12, MSC 6300
Bethesda, MD  20892-6300
Telephone:  (301) 594-6869
FAX:  (301) 480-8260
Email:  jeff_carow@nih.gov

NLM
Dwight Mowery
Extramural Programs
National Library of Medicine
6705 Rockledge Drive, Suite 301
Bethesda, MD  20871
Telephone:  (301) 496-4221
FAX:  (301) 402-2952
Email:  moweryd@mail.nlm.nih.gov

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance Nos.
93.394, 93.395, 93.396, 93.306, 93.867, 93.172, 93.837, 93.838, 93.839, 93.866,
93.273, 93.855, 93.856, 93.846, 93.864, 93.865, 93.929, 93.279, 93.173, 93.121,
93.847, 93.848, 93.849, 93.113, 93.821, 93.859, 93.862, 93.242, 93.853, 93.854,
93.361, and 93.879.  Awards are made under authorization of the Public Health
Service Act, Sec. 301, Title IV, Part A (Public Law 78-410, as amended by Public
Law 99-158, 42 USC 241 and 285). Awards will be administered under PHS grants
policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74 and Part 92.
This program is not subject to the intergovernmental review requirements of
Executive Order 12372 or Health Systems review.

The PHS strongly encourages all grant and contract recipients to provide a smoke-
free workplace and promote the non-use of all tobacco products.  In addition,
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain
facilities (or, in some cases, any portion of a facility) in which regular or
routine education, library, day care, health care or early childhood development
services are provided to children. This is consistent with the PHS mission to
protect and advance the physical and mental health of the American people.


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