Full Text PAR-96-031 NIDDK-NIAID INTERNATIONAL COLLABORATION: SMALL GRANT AWARDS NIH GUIDE, Volume 25, Number 7, March 8, 1996 PA NUMBER: PAR-96-031 P.T. 34 Keywords: Biomedical Research, Multidiscipl Diabetes Digestive Diseases & Disorders 0715133 Metabolic Diseases National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Allergy and Infectious Diseases PURPOSE The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health announce a pilot program to promote collaborative biomedical research efforts in both clinical and basic science research that addresses the mission of the NIDDK. The grant mechanism used is the small grant (R03), which provides limited funds (maximum of $50,000 direct costs per year) for short-term (up to two years) research projects. The small grant awards (R03) responsive to this Program Announcement support either clinical or basic science collaborative research efforts related to the mission of the NIDDK that are performed outside the United States, taking advantage of established NIAID-supported International Centers. Investigators are encouraged to establish formal collaboration(s) with the Director or participating scientists of a NIAID International Center(s) and submit an application for small grant support to initiate small research projects or pilot investigations that would have specific aims consistent with the mission of the NIDDK and the research scope of the NIAID International Center. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This PA, NIDDK-NIAID International Collaboration: Small Grants Awards, is related to the priority area of chronic disabling conditions. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Applications may be from one institution or as consortia with NIAID-supported International centers. MECHANISM OF SUPPORT Support for this Program Announcement will be through the NIH small grants (R03) mechanism. The small grants research program provides limited funds (maximum of $50,000 direct costs per year) for short term (up to two years) research projects. These grants are non-renewable, but continuation of projects developed under this program can be supported by the investigator-initiated research project grant (R01) mechanism. Applicants will be responsible for the planning, direction, and execution of the proposed project. Applications submitted in response to this PA will compete for funds with other R03 and regular research project grant applications assigned to the NIDDK. Applications from institutions that have a General Clinical Research Center (GCRC) funded by the NIH National Center for Research Resources may wish to identify the GCRC as a resource for conducting the proposed research. If so, a letter of agreement from either the GCRC program director or principal investigator should be included with the application. The award of grants in response to this PA is also contingent upon the availability of funds. Awards will be administered under PHS grants policy as stated in the PHS Grants Policy Statement (rev. 4/94). RESEARCH OBJECTIVES The mission of the NIDDK is to provide broad fundamental and clinical research support for a spectrum of chronic and disabling diseases including: diabetes mellitus, digestive diseases, kidney and urologic diseases, hematological diseases, metabolic and endocrine diseases, nutritional disorders and obesity. Noting that collaborative international research provides special opportunities for furthering the mission of the NIH through unusual resources, populations and environmental conditions, the NIDDK invites applications for small grants to augment collaborative international research. The major areas of interest and potential that have been identified relevant to this new program are the following: o autoimmune liver diseases and hepatitis o gastric ulcer disease and Helicobacter pylori o parasitic diseases which have an impact on liver o mucosal immunity o pediatric liver disease o influence of altered nutritional status on health and disease o parasitic diseases with kidney/urinary tract sequelae o hemolytic uremic syndrome o infectious diseases of the kidney o benign prostatic hypertrophy in minority populations o therapies for hematologic disorders such as iron chelating agents o diabetic kidney disease o hypertensive kidney disease Small grant applications for support of research on these and related topics can be submitted in collaboration with existing NIAID-supported International Centers. A current list of those centers and full information about their specific research areas can be obtained from the NIAID staff contact listed in the INQUIRIES section. Currently, the countries and general foci of research represented in the NIAID International Centers Program are: BRAZIL: Leishmaniasis, Malaria, Schistosomiasis Chagas' Disease, Immunoparasitology, Diarrheal Diseases, Hydatid Diseases, CAMEROON: Malaria CHILE: Cholera & Enteric Diseases MEXICO: Tuberculosis PERU: Enteric Pathogens, Neurocysticercosis EGYPT: Lymphatic Filariasis ISRAEL: Diarrheal Diseases, Leishmaniasis, Hydatid Diseases KENYA: Schistosomiasis, Filariasis, Hydatid disease NEPAL: Geohelminths SOUTH AFRICA: Amoebiasis THAILAND: Malaria LEBANON: Leishmaniasis UGANDA: Tuberculosis MOROCCO: Leishmaniasis JORDAN: Leishmaniasis TUNISIA: Hydatid Diseases INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification is provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This new policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43) and supersedes and strengthens the previous policies (Concerning the Inclusion of Women in Study Populations, and Concerning the Inclusion of Minorities in Study Populations), which have been in effect since 1990. The new policy contains some provisions that are substantially different from the 1990 policies. All investigators proposing research involving human subjects should read the "NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical Research," which have been published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and reprinted in the NIH Guide for Grants and Contracts, Volume 23, Number 11, March 18, 1994. Investigators also may obtain copies of the policy from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. APPLICATION PROCEDURES The research grant application form PHS 398 (rev. 5/95) is to be used in applying for these grants. Applications kits are available at most institutional offices of sponsored research and may be obtained from the Grants Information Office, Office of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/710-0267, email: girg@drgpo.drg.nih.gov. The completed original application and five legible copies must be sent or delivered to: DIVISION OF RESEARCH GRANTS NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040-MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) REVIEW CONSIDERATIONS Applications will be assigned on the basis of established Public Health Service referral guidelines. Applications that are complete and responsive to this program announcement will be evaluated for scientific and technical merit by an appropriate peer review group convened by the NIDDK in accordance with NIH peer review procedures. As part of the initial merit review, all applications will receive a written critique and undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of applications under review, will be discussed, assigned a priority score, and receive a second level review by the appropriate national advisory council or board. Review Criteria o scientific, technical, or medical significance and originality of proposed research; o appropriateness and adequacy of the experimental approach and methodology proposed to carry out the research; o qualifications and research experience of the Principal Investigator and staff, particularly, but not exclusively, in the area of the proposed research; o availability of the resources necessary to perform the research; o appropriateness of the proposed budget and duration in relation to the proposed research; o adequacy of plans to include both genders and minorities and their subgroups as appropriate for the scientific goals of the research. Plans for the recruitment and retention of subjects will also be evaluated. o availability of special opportunities for furthering research programs through the use of unusual talent resources, populations, or environmental conditions in other countries that are not readily available in the United States or that provide augmentation of existing U.S. resources. The initial review group will also examine the provisions for the protection of human and animal subjects and the safety of the research environment. AWARD CRITERIA Applications will compete for available funds with all other approved applications assigned to the National Institute of Diabetes and Digestive and Kidney Diseases. The following will be considered in making funding decisions: o Quality of the proposed project as determined by peer review o Availability of funds o NIDDK Program priority. INQUIRIES Inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Individuals interested in this new program are encouraged to contact the relevant Program Official below: For inquiries related to the mission of the NIDDK: Thomas F. Kresina, PhD Division of Digestive Diseases and Nutrition National Institute of Diabetes and Digestive and Kidney Diseases Building 45, Room 6AN-12A, MSC 6600 Bethesda, MD 20892-6600 Telephone: (301) 594-8871 FAX: (301) 480-8300 Email: kresinat@ep.niddk.nih.gov Camille A. Jones, MD., MPH Division of Kidney, Urologic and Hematologic Diseases National Institute of Diabetes and Digestive and Kidney Diseases Building 45, Room 6AS-13K, MSC 6600 Bethesda, MD 20892-6600 Telephone: (301) 594-7715 FAX: (301) 480-3510 Email: camille-jones @nih.gov For inquiries related to the NIAID International Centers: Dr. Michael Gottlieb Parasitology and International Programs Branch National Institute of Allergy and Infectious Diseases Solar Building, Room 3A12 - MSC 7630 Bethesda, MD 20892-7630 Telephone: (301) 496-7115 FAX: (301) 402-0659 Email: mg35s@nih.gov Direct inquiries regarding fiscal and administrative matters to: Ms. Nancy Dixon Supervisory Grants Management Specialist National Institute of Diabetes and Digestive and Kidney Diseases 45 Center Drive MSC 6600 Bethesda, MD 20892-6600 Telephone: (301) 594-8854 FAX: (301) 480-3504 Email: dixonn@ep.niddk.nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.848 and 93.849. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant and contract recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people. .
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