THE HOWARD TEMIN AWARD

Release Date:  February 22, 2000 (see replacement PAR-03-104)

PA NUMBER:  PAR-00-066

National Cancer Institute

This program announcement (PA) replaces PAR-99-063, which was published in 
the NIH Guide on February 12, 1999

PURPOSE

The goal of the National Cancer Institute's (NCI) Howard Temin Award is to 
bridge the transition from a mentored research environment to an independent 
research career for scientists who have demonstrated unusually high potential 
during their initial stages of training and development.  This special award 
is aimed at fostering the research careers of outstanding junior  scientists 
in basic research who are committed to developing research programs directly
relevant to the understanding of human biology and human disease as it 
relates to the etiology, pathogenesis, prevention, diagnosis, and treatment 
of human cancer.  The major objective of the award is to sustain and advance 
the early research careers of the most promising M.D.s and Ph.D.s while they 
consolidate and focus their independent research programs, and obtain their 
own research grant support.  To achieve this objective, the Howard Temin 
Award offers candidates up to five years to develop knowledge in the basic 
sciences and research skills relevant to the candidate's career goals, with 
up to three of the initial years (at least one year required) in a mentored 
environment followed by a transition to an unmentored independent 
investigator phase for the remaining time on the award.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health 
promotion and disease prevention objectives of "Healthy People 2000," a 
PHS-led national activity for setting priority areas.  This PA, "The Howard 
Temin Award", is related to the priority area of cancer and human resource 
development.  Potential applicants may obtain a copy of "Healthy People 2000" 
at (http://odphp.osophs.dhhs.gov/pubs/hp2000). 

ELIGIBILITY REQUIREMENTS

Applicants are encouraged to contact the NCI program staff listed under 
INQUIRIES regarding their eligibility for this award prior to the preparation 
of an application.

The candidate must have a research or a health professional doctorate or its 
equivalent, must have completed at least three years of postdoctoral research 
at the time of award, and must have demonstrated highly productive research 
activity and the potential for establishing an independent research program 
in the period after the doctorate.  Recipients of an NCI Preventive 
Oncology/Population Sciences Career Development (K07) Award, a Mentored 
Clinical Research Scientist Career Development (K08) Award or a Mentored 
Patient-Oriented Research Career Development (K23) Award who are in their 
last two years of support are also eligible to apply.  The career development 
award will be terminated upon acceptance of a Howard Temin Award.

Candidates must be able to identify an individual who can serve as a mentor 
for some portion of the initial mentored phase of this award.

Former or current principal investigators on NIH Small Grants (i.e., R03s) or 
Exploratory/Developmental Grants (i.e., R21s) remain ELIGIBLE to apply.  
However, former or current principal investigators on NIH research projects 
(i.e., R01s), FIRST Awards (i.e., R29s), sub-projects on Program Project 
Grants (i.e., P01s) or center grants (i.e., P50s) and their equivalents are 
NOT ELIGIBLE. 

Applications may be submitted, on behalf of candidates, by domestic, 
non-Federal organizations, public or private, such as medical, dental, or 
nursing schools or other institutions of higher education. Racial/ethnic 
minority individuals, women, and persons with disabilities are encouraged to 
apply as principal investigators. Candidates must be U.S. citizens or 
non-citizen nationals, or must have been lawfully admitted for permanent 
residence by the time of award.  Individuals admitted for permanent residence 
must be able to produce documentation of their immigration status such as an 
Alien Registration Receipt Card (I-151 or I-551) or some other verification 
of legal admission as a permanent resident.  Non-citizen nationals, although 
not U.S. citizens, owe permanent allegiance to the U.S.  They are usually 
born in lands that are not states but are under U.S. sovereignty, 
jurisdiction, or administration.  Individuals on temporary or student visas 
are not eligible for this award.

MECHANISM OF SUPPORT

This PA will use the National Institutes of Health (NIH) K01 mechanism.  The 
total project period for an application submitted in response to this PA may 
not exceed 5 years.  The actual length of the awarded project period will 
depend upon the number of years of prior research experience and the need for 
additional experiences to achieve independence.  Planning, direction, and 
execution of the program will be the responsibility of the candidate and 
her/his mentor on behalf of the applicant institution.  Awards are not 
renewable.

FUNDS AVAILABLE

The Howard Temin award is a highly competitive award, with the intent of 
providing support to outstanding junior scientists during their transition to 
an independent investigator status. 

RESEARCH OBJECTIVES

A.  Purpose: The National Cancer Institute is interested in encouraging basic 
scientists to become more interested in research problems of high relevance 
to human biology particularly as they relate to the etiology, pathogenesis, 
prevention, diagnosis, control and treatment of human cancer.  In the past, 
the major effort of the NCI has been to encourage medically trained 
individuals to become interested in basic research problems at the most 
fundamental biological levels, but there has been no effort to encourage 
scientists trained in the basic sciences to focus on problems of direct 
relevance to the clinical sciences or the prevention, control and population 
sciences.  The continued success of future cancer research will depend upon 
the increased ability of the cancer biomedical research community to 
effectively translate observations in the laboratory into patient and 
population research settings.  Well-trained basic scientists who focus their 
research on human biology and human disease will be an essential component of 
the translational research enterprise.  The Howard Temin Award not only 
offers continuing encouragement to clinicians for training in basic research, 
but additionally represents a complementary new effort to encourage 
scientists trained in the basic sciences to focus on problems of direct high 
relevance to the clinical sciences or the prevention, control and population 
sciences as they relate to cancer. Specifically, the Howard Temin Award 
provides an opportunity for medically trained individuals and basic 
scientists to initially work under a mentor in an institutional environment 
that will enable them to transition to an independent research position and 
acquire research support focused on issues and problems directly relevant to 
human cancer.

B.  Environment: The institution must have a well-established basic research 
and/or clinical career development program(s) and qualified faculty to serve 
as mentors.  The candidate, mentor and institution must be able to describe a 
multi-disciplinary career development program in basic research that will 
maximize the use of relevant research and educational resources.

C. Program: The award provides up to five consecutive 12 month appointments. 
At least 75 percent of the recipient's full-time professional effort must be 
devoted to the program and the remainder devoted to other research-related 
and/or teaching pursuits consistent with the objectives of the award.  The 
candidate must develop knowledge in the basic sciences and research skills 
relevant to his or her career goals.  The candidate may find it appropriate 
to include relevant didactic and laboratory or field research experiences.

D.  Mentor(s): The recipient must receive appropriate mentoring during some 
fraction of the first three years of the initial phase of the award.  The 
candidate may move to an unmentored research environment only on the award 
anniversary dates of the second, third and fourth year of support.  See the 
SUPPLEMENTAL GUIDELINES FOR TRANSITION TO THE UNMENTORED STATE below.  The 
transition must take place no later than the end of the third year.  The 
transition application Where feasible, women and minority mentors should be 
involved as role models.

E.  Allowable Costs:

1.  Salary: The Temin award will provide salary up to $75,000 plus fringe 
benefits.  The total salary requested must be based on a full-time, 12 month, 
staff appointment requiring the candidate to spend a minimum of 75 percent 
effort conducting cancer research with the remaining effort being devoted to 
activities related to the development of a successful research career.  The 
salary must be consistent both with the established salary structure at the 
institution and with salaries actually provided by the institution from its 
own funds to other staff members of equivalent qualifications, rank, and 
responsibilities in the department concerned.  If full-time, 12 month 
salaries are not currently paid to comparable staff members, the salary 
proposed must
be appropriately related to the existing salary structure.

2.  Research Development Support: During the mentored phase of the award, 
$30,000 per year will be provided for the following types of expenses: (a) 
research expenses, such as supplies, equipment, and technical personnel; (b) 
statistical services including personnel and computer time; (c) tuition, 
fees, and books related to career development; and (d) travel to research 
meetings or for training.  The amount of this support will increase to 
$50,000 when the principal investigator transitions to an independent 
research position either at the same institution or at a different 
institution.

3.  Ancillary Personnel Support: Salary for mentors, secretarial and 
administrative assistance, etc. is not allowed.

4. Facilities and Administrative Costs:  These costs, which were formerly 
called indirect costs, will be reimbursed at 8 percent of modified total 
direct costs.

F. Evaluation:  In carrying out its stewardship of human resource related 
programs, the NIH may begin requesting information essential to an assessment 
of the effectiveness of this program.  Accordingly, recipients are hereby 
notified, that they may be contacted after the completion of this award for 
periodic updates on various aspects of their employment history, 
publications, support from research grants or contracts, honors and awards, 
professional activities, and other information helpful in evaluating the 
impact of the program.

G. Other Income: Fees resulting from clinical practice, professional 
consultation, or other comparable activities required by the research and 
research-related activities of this award may not be retained by the career 
award recipient.  Such fees must be assigned to the grantee institution for 
disposition by any of the following methods:

o The funds may be expended by the grantee institution in accordance with the 
NIH policy on supplementation of career award salaries and to provide fringe 
benefits in proportion to such supplementation. Such salary supplementation 
and fringe benefit payments must be within the established policies of the 
grantee institution;
o The funds may be used for health-related research purposes;
o The funds may be paid to miscellaneous receipts of the U.S. Treasury. 
Checks should be made payable to the Department of Health and Human Services, 
NIH and forwarded to the Director, Office of Financial Management, NIH, 
Bethesda, Maryland 20892.  Checks must identify the relevant award account 
and reason for the payment;
o Awardees may retain royalties and fees for activities such as scholarly 
writing, service on advisory groups, or honoraria from other institutions for 
lectures or seminars, provided these activities remain incidental and 
provided that the retention of such pay is consistent with the policies and 
practices of the grantee institution.

Usually, funds budgeted in an NIH supported research or research training 
grant for the salaries or fringe benefits of individuals, but freed as a 
result of a career award, may not be rebudgeted.  The awarding component will 
give consideration to approval for the use of released funds only under 
unusual circumstances.  Any proposed retention of funds released as a result 
of a career award must receive prior written approval of the NIH awarding 
component.

H. Special Leave: Leave to another institution, including a foreign 
laboratory may be permitted if the proposed experience is directly related to 
the purpose of the award.  Only local, institutional approval is required if 
such leave does not exceed 3 months.  For longer periods, prior written 
approval of the NIH funding component is required.  To obtain prior approval, 
the award recipient must submit a letter to the NIH funding component 
describing the plan, countersigned by his or her department head and the 
appropriate institutional official.  A copy of a letter or other evidence 
from the institution where the leave is to be taken must be submitted to 
assure that satisfactory arrangements have been made.  Support from the 
career award will continue during such leave.

Leave without award support may not exceed 12 months.  Such leave requires 
the prior written approval of the NIH funding component and will be granted 
only in unusual situations.  Support from other sources is permissible during 
the period of leave.  Such leave does not reduce the total number of months 
of program support for which an individual is eligible.

Under unusual and pressing circumstances, an awardee may submit a written 
request to the awarding component, requesting a reduction in professional 
effort below 75 percent.  Such requests will be considered on a case-by-case 
basis during the award period.  In no case, will it be permissible to work at 
a rate of less than 50 percent effort.  The nature of the circumstances 
requiring reduced effort might include medical conditions, disability, or 
pressing personal or family situations such as child or elder care.  
Permission to reduce the level of effort will not be approved to accommodate 
other sources of funding, job opportunities, clinical practice, or clinical 
training.  In each situation, the grantee institution must submit 
documentation supporting the need for reduced effort along with assurance of 
a continuing commitment to the scientific development of the awardee.  
Further, the  awardee must submit assurance of his or her intention to return 
to full-time professional effort (at least 75 percent) as soon as possible.  
During the period of reduced effort, the salary and other costs supported by 
the award will be reduced accordingly.

I. Termination or Change of Institution:  When a grantee institution plans to 
terminate an award, the NIH funding component must be notified in writing at 
the earliest possible time so that appropriate instructions can be given for 
termination. The Director of the NIH may discontinue an award upon 
determination that the purpose or terms of the award are not being fulfilled.  
In the event an award is terminated, the Director of the NIH shall notify the 
grantee institution and career award recipient in writing of this 
determination, the reasons therefor, the effective date, and the right to 
appeal the decision.

Awardees planning a change of institution, must submit to the funding NIH 
component in advance of the change a written request for transfer, 
countersigned by the appropriate institutional business official, describing 
the reasons for the change and including the new sponsor's name and 
biosketch. The awardee must establish in this request that the specific aims 
of the research program to be conducted at the new institution are within the 
scope of the original peer reviewed research program.  Additionally, the new 
sponsor must have the appropriate research expertise to supervise the program 
and sufficient research  support to ensure continuation of the research 
program to the end of the award (initial award).  Staff within the NIH 
funding component will review this request and may require a review by an 
initial review group and/or the appropriate National Advisory Council or 
Board. Upon approval of this request, a new career award application must be 
submitted by the new institution far enough in advance of the requested 
effective date to permit review.  The period of support requested in the new 
application must be no more than the time remaining within the existing award 
period.

J.  Change of Mentor:  When a mentor at the grantee institution is to be 
replaced, the institution must submit a letter from the proposed mentor 
documenting the need for substitution, the new mentor's qualifications for 
supervising the program, and the level of support for the candidate's career 
development.  The letter must also document that the specific aims of the 
research program will remain within the scope of the original peer reviewed 
research program.  Staff within the NIH funding component will review the 
request, and will notify the grantee institution of the results of the 
evaluation.

A final progress report, invention statement, and Financial Status Report are 
required upon either termination of an award or relinquishment of an award in 
a change of institution situation.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of the NIH that women and members of minority groups and 
their subpopulations must be included in all NIH supported biomedical and 
behavioral research projects involving human subjects unless a clear and 
compelling rationale and justification is provided that inclusion is 
inappropriate with respect to the health of the subjects or the purpose of 
the research.  This policy results from the NIH Revitalization Act of 1993 
(Section 492B of Public Law 103-43).

All investigators proposing research involving human subjects should read the 
"NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical 
Research," which has been published in the Federal Register of March 20, 1994 
(FR 59 14508-14513), and in the NIH Guide for Grants and Contracts, Volume 
23, Number 11, March 18, 1994 available electronically at
http://grants.nih.gov/grants/guide/notice-files/not94-100.html.


Investigators may obtain copies from these sources or from the program staff 
or contact person listed under INQUIRIES.  Program staff may also provide 
additional relevant information concerning the policy.

INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of NIH that children (i.e., individuals under the age of 21) 
must be included in all human subjects research, conducted or supported by 
NIH, unless there are clear and compelling scientific and ethical reasons not 
to include them. This policy applies to all initial (Type 1) applications 
submitted for receipt dates after October 1, 1998.

All investigators proposing research involving human subjects should read the 
"NIH Policy and Guidelines on the Inclusion of Children as Participants in 
Research Involving Human Subjects" that was published in the NIH GUIDE FOR 
GRANTS AND CONTRACTS, March 6, 1998 and is available at the following URL 
address: http://grants.nih.gov/grants/guide/notice-files/not98-024.html.

APPLICATION PROCEDURES

Applications are to be submitted on the grant application form PHS 398 (rev. 
4/98) and should use the instructions in Section IV of the application kit.  
Applications will be accepted at the standard application deadlines as 
indicated in the application kit.  Application kits are available at most 
institutional offices of sponsored research and from the Division of 
Extramural Outreach and Information Resources, National Institutes of Health, 
6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 
301/435-0714, Email: grantsinfo@nih.gov.  The title and number of the PA must 
be typed in Section 2 on the face page of the application form and the YES 
box must be marked.  Application kits are also available on the world wide 
web at: http://grants.nih.gov/grants/funding/phs398/forms_toc.html.

All applications and proposals for NIH funding must be self-contained within 
specified page limitations.  Unless otherwise specified in an NIH 
solicitation, internet addresses (URLs) should not be used to provide 
information necessary to the review because reviewers are under no obligation 
to view Internet sites.  Reviewers are cautioned that their anonymity may be 
compromised when they directly access an Internet site (see  
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-004.html).

The completed original application and three legible copies must be sent or 
delivered to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

At the time of submission, two additional copies of the application must be 
sent to:

Ms. Toby Friedberg
Division of Extramural Activities
National Cancer Institute
6116 Executive Boulevard, Room 8062
MSC 8329
Bethesda, MD  20892-8329
Rockville, MD 20852 (for express/courier service)

The application must address the following issues and include the following 
information:

Candidate

o  Describe the candidate's commitment to a career in basic biomedical 
research directly relevant to human biology and cancer (candidates interested 
in patient-oriented  research should consider the Mentored, Patient-Oriented 
Research Career Development Award (K23);

o  Present evidence of the candidate's ability to interact and collaborate 
with other scientists;

o  Discuss prior training and how it relates to the objectives and plans of 
the candidate;

o  Discuss the innovativeness and quality of the candidate's research efforts 
to this point in his/her research career;

o  Letters of recommendation.  Three sealed letters of recommendation 
addressing the following issues:

- The adequacy of the candidate's scientific background for the proposed 
research and career goals.

- The quality of the candidate's scientific productivity and achievements 
(e.g. publications, intellectual contributions to the research environment)

- The candidate's ability to work with other scientists in various 
interactive situations (e.g., seminars, journal clubs), on collaborative 
research projects, and with support staff (e.g., technicians, nurses, 
secretaries etc.)

- Evidence of the candidate's originality and innovativeness in pursuing a 
research problem

- VERY IMPORTANTLY, the candidate's special potential to develop, establish 
and manage an independent research program.
        
Career Development Plan

o  Present a systematic plan that covers the mentored and unmentored phases 
of this Program.  This plan should incorporate  the prior research training 
and experience of the candidate to provide a basis for the need for further 
career development to become an independent investigator focusing on cancer 
research that is directly relevant to human biology and human disease.  The 
plan should provide a description of the research and training experiences 
that will occur during the mentored and unmentored phases; and must present a 
convincing case that, as a result of these experiences, the candidate will 
have a high probability of developing the research skills and ability needed 
to work in a collaborative environment and become a successful independently 
supported investigator. The plan must include a statement regarding the 
proposed length of the mentored and unmentored phases; the unmentored phase 
must begin on the anniversary award date of the second, third or fourth year 
of the grant.

o  Document prior instruction in or propose plans for instruction in the 
responsible conduct of research in terms of subject matter and duration of 
instruction.  (NO AWARD CAN BE MADE IF AN APPLICATION LACKS THIS COMPONENT).

Research Plan

o  Describe the research plan using Form PHS 398 (rev. 4/98 or subsequent 
revisions) following instructions for the  Specific Aims, Background and 
Significance, Progress Report/Preliminary Studies, Research Design and 
Methods.  The candidate should consult with the mentor regarding the 
development of this section.  The research plan must be directly relevant to 
human biology and human cancer disease.  It must be clear whether all or 
parts of the Research Plan will go with the candidate when the transition to 
an independent position is made or whether the candidate will be expected to 
develop an entirely new project in the independent position.

Mentor's Statement

o  The application must include a signed statement from the mentor(s) 
including information on research qualifications and previous experience as a 
research supervisor.  The applications must also include information to 
describe the mentor's research support related to the candidate's research 
plan and nature of the supervision that will occur during the mentored phase 
of the proposed award period;

o  Similar information must be provided by any co-mentor.  If more than one  
mentor is proposed, the respective areas of expertise and responsibility 
should be described.

o This statement should also specifically describe whether all or parts of 
the research project being conducted by the candidate will go with the 
candidate when the transition to an independent position is made or whether 
the candidate will be expected to develop and entirely new project in the 
independent position.

Environment and Institutional Commitment

o  Describe the resources and facilities that will be available to the 
candidate;

o  Describe how the research environment of the institution is particularly 
suited for the development of the candidate's research career and the pursuit 
of the proposed research plan;

o  In a clear statement, provide assurances that the candidate will be able 
to spend a minimum of 75 percent effort in the development of his/her 
research program, with the remaining percent effort spent on activities 
related to the development of their research career.

Biographical Sketch

o  Biographical Sketch

A biographical sketch is required for all key personnel.  Provide information 
on research projects completed and/or research grants participated in during 
the last five years that are relevant to the proposed project.

Budget
Applicants using a PHS 398 Form bearing the revision date 4/98 must follow 
the instructions in the form.

REVIEW CONSIDERATIONS

Applications will be reviewed for completeness by the Center for Scientific 
Review and for adherence to the guidelines of this PA by the National Cancer 
Institute.  Incomplete applications will be returned to the applicant without 
further consideration.  Applications that are complete and responsive to the 
PA will be evaluated for scientific and technical merit by an appropriate 
scientific review group convened by the National Cancer Institute in 
accordance with the standard NIH peer review procedures.  As part of the 
initial merit review, all applications will receive a written critique, and 
may undergo a process in which only those applications deemed to have the 
highest scientific merit, generally the top half of applications under 
review, will be discussed, assigned a priority score, and receive a second 
level review by the National Cancer Advisory Board.

The following review criteria will be applied:

Candidate

o  Commitment of the candidate to a career in basic cancer research that will 
be focused on problems directly relevant to human biology and human cancer 
disease;

o  Ability of the candidate to interact and collaborate with other 
scientists;

o  Quality of the prior scientific training and experience, including 
publications that establish the innovativeness of the candidate in research 
and a high potential for an independent research career;

o  Recommendations of three well-established scientists attesting to the 
special potential of the individual to pursue an independent career in cancer 
research.

Career Development Plan

o  Likelihood that the plan will contribute substantially to the scientific 
development of the candidate, and the achievement of an independent research 
program directly relevant to human biology and human cancer disease, based 
on: 

- Candidate's prior training and research experience;

- Appropriateness of the goals and scope of the plan to complement prior 
training/research experience and achieve the stated training and research 
objectives;

o  Appropriateness of the proposed durations of the mentored and unmentored
phases;

o  Appropriateness of the proposed activities during the mentored and 
unmentored phases for a five year award;

o  Adequacy of prior or proposed training in the responsible conduct of
research.

Research Plan

o  Degree of relevance of the research plan to developing an independent 
research program focused on human biology and human disease as they relate to 
the etiology, pathogenesis, prevention, diagnosis, and/or treatment of human 
cancer;

o  A sound research project that is consistent with the development plan for 
an independent career in cancer research and the candidate's level of 
research development must be provided (All applicants for this award will 
have had previous postdoctoral research experience and in some cases may have 
been Principal Investigators on small research grants);

o  Usefulness of the research plan as a vehicle for enhancing existing 
research skills as described in the career development plan;

o  The originality and quality of the research hypothesis/question, design 
and methodology, judged in the context of the candidate's previous training 
and experience.

o Attention to and implications of what aspects of Plan will go with the 
candidate at the time of the transition to an independent position.

o Adequacy of the Plans attention to children, gender, and minority issues 
when human subjects are involved.

Mentor/ Co-Mentor

o  Appropriateness of the mentor's research qualifications in the area of the 
proposed research;

o Quality and extent of the mentor(s)'s proposed role in providing guidance 
and advice to the candidate.

o  Previous experience in fostering the development of cancer researchers;

o  History of research productivity and peer reviewed support;

o  Adequacy of existing support for the mentored phase of the proposed 
research project.

o Adequacy and clarity of the mentor(s)'s statement describing what aspects 
of the Research Plan will go with the candidate when the transition is made 
to an independent position.

Institutional Environment and Commitment

o  Clear commitment of the institution to ensure that a minimum of 75 percent 
of the candidate's effort will be devoted directly to research, with the 
remaining percent effort being devoted to activities related to the 
successful development of a research career;

o  Adequacy of research facilities and training opportunities;

o  Quality and relevance of the environment for scientific and professional 
development of the candidate.

Budget

o  Justification of the requested budget in relation to career development 
goals and research aims and plans.

AWARD CRITERIA

The NCI will notify the applicant of the National Cancer Advisory Board's 
(NCAB) action shortly after its meeting.  Funding decisions will be made 
based on the scientific merit of the application as evaluated by the initial 
review group, the results of the secondary review by the NCAB, the need for 
research personnel in specific program areas, and the availability of funds.

SUPPLEMENTAL GUIDELINES FOR TRANSITION TO THE UNMENTORED PHASE

These guidelines apply only to the non-competing year in which the transition 
is requested.  Other non-competing applications should be completed in 
accordance with the guidelines for streamlined (SNAP) applications outlines 
in PHS form 2590.

Application Procedure:

The application procedure for the initial Howard Temin Award cannot be used 
for the transition to an unmentored status.  Therefore, follow the 
supplemental application guidelines below for this aspect of the Award:

When the candidate is remaining in the same institution, transition 
applications are to be submitted on the Application for Continuation Grant 
Form PHS 2590 (rev. 4/98 and subsequent revisions), including the additional 
instructions for Research Career Award Applications starting on page IV-1.  
When the candidate is changing institution, the application form to use is 
the Form PHS 398, and it should be obtained from the grantee institution.  
However,  the NCI (see INQUIRIES) will provide a  transfer  application kit 
,which includes the Form PHS 398, for this purpose.  Transition applications 
MUST be submitted for support two months prior to the anniversary date of the 
second, third or fourth year of the award.

Submit a signed, typewritten original of the signed application and two 
signed photocopies in one package to:

Records Management Center
Grants Administration
National Cancer Institute
Executive Plaza South, Suite T-42 MSC 7107
Bethesda, MD 20892-7107

Special instructions for completion of the application:

o  To associate the application with a transition request, enter "NCI HOWARD 
TEMIN AWARD (K01) TRANSITION" on Line 1, Form Page 1;

o  Provide an itemized listing with associated projected costs for all items 
on Form Page 2 (DETAILED BUDGET FOR NEXT BUDGET PERIOD).  Also see 
Instructions;

o  Biographical Sketch (Form Page 4):  Provide for all key personnel to be 
involved in the research project.  Provide information on research projects 
completed and/or research grants participated in during the last five years 
that are relevant to the proposed project.

o  Progress Report Summary (Form Page 5): Follow guidelines in Instructions.
Additional instructions include:

- This section should be keep as short as possible.  However, due to the 
unique reporting requirements for the "transition" application, the section 
may exceed two pages;

- Studies and Results (Item b):  The information provided must clearly 
justify a transition to the unmentored phase of the award;

- Plans (Item b): Follow the guidelines in the Instructions.  Additional 
information to be provided is as follows:

o  Describe how the scope of the project initiated during the unmentored 
phase will be changed in response to the increased level of research support 
provided in the mentored phase of this award.  Provide detailed research 
plans if there is a major change in research scope of the original peer 
reviewed research plan;

o  Describe the DIRECT relevance of the research plan to the etiology, 
pathogenesis, prevention, diagnosis, and/or treatment of human cancer;

o  Describe how the proposed research and research-related activities should 
contribute to the scientific development of  the candidate, and the 
development of an independently funded research program; 

o  Describe long term research career goals, including the timing of 
submission of applications for investigator-initiated research grants; 

o  Provide a statement from the Chairperson of the department to which the 
awardee has been recruited describing the type of faculty position offered 
and if it is a tenure-track position (or equivalent); the responsibilities of 
the position; the laboratory facilities that will be provided for exclusive 
use by the awardee, and the relationship of these facilities to the 
laboratories of
the applicant's mentor (if the transition does not involve a change of 
sponsoring institution); additional non-PHS research related 
departmental/institutional support that will be provided for technical 
support staff, equipment, animals, etc; relationship of the awardee's 
research program
to ongoing programs within the department; career plans for the awardee;

o  Provide a statement from the institution ensuring that a minimum of 75 
percent of the candidate's effort will be devoted directly to research, with 
the remaining percent effort being devoted to activities related to the 
successful development of a research career;

o  If the transition involves a change of sponsoring institution, the new 
institution must additionally document a strong, well-established program in 
biomedical research related to cancer, including a high quality research 
environment with staff capable of productive collaboration with the 
candidate.

CANDIDATES PLANNING A CHANGE OF INSTITUTION MUST CONTACT NCI PROGRAM STAFF 
PRIOR TO SUBMISSION OF THE TRANSITION APPLICATION.

o  Provide a sealed statement from the mentor recommending the candidate for 
the transition.  This recommendation should be based on the scientific 
productivity of the candidate under his/her mentorship, and on the mentor's 
detailed evaluation that the candidate is ready to develop an innovative and 
independently-supported research program.  This letter should be mailed 
directly to the NCI Program Director for the candidate's Howard Temin Award.

Review Considerations for a "Transition" Application:
Applications received will require NCI staff approval before the transition 
award to an independent position is activated.  Depending upon the scope of 
changes in the research plan as compared with the original peer reviewed 
grant application, the application could receive a second level of review by 
an IRG.  Approval will be based upon the following criteria:

o  A statement from the mentor(s) verifying that the candidate is ready to 
pursue an independent research career.

o  The clear direct relevance of the new Research Plan to human biology and 
human disease as they relate to cancer etiology, pathogenesis, prevention, 
control, diagnosis and treatment;

o  The soundness of the "Letter of Commitment" from the institution, to 
provide the candidate with protected time (no less than 75 percent effort 
dedicated to the development of a research program with the remaining effort 
to be used in research related activities) and describing arrangements with 
the candidate providing a permanent preferably tenure-track position, 
adequate facilities for conducting a research program, and additional 
resources conducive to the development of a research project and 
establishment of a successful research career;

o  The adequacy of the plans for inclusion of women, children, and minorities 
in any clinical or population research activities, as applicable;

o  The adequacy of the proposed protection of humans, animals or the 
environment to the extent that they may be adversely affected by the 
activities proposed in this application.

Award Criteria for a "Transition" Application:

Funding decisions will be made by NCI program staff based on satisfying the 
review considerations above.  NCI program staff will notify the applicant for 
the transition to unmentored status of their  action on the application.  The 
transition to the unmentored phase will take effect on the anniversary date 
of the grant.

INQUIRIES

Inquiries are encouraged.  The opportunity to clarify any issues or questions 
from potential applicants is welcome.   Depending upon whether your inquiry 
involves application strategies and scientific issues, budget or fiscal 
issues or review issues, contact the appropriate individual noted below:

Direct inquiries regarding programmatic issues to:

Dr. Andrew Vargosko
Office of Centers, Training and Resources
National Cancer Institute
6116 Executive Blvd., Suite 7011
MSC/8346
Bethesda, MD  20892-8346
Telephone:  (301) 496-8580
FAX:  (301) 402-4472
Email: av8b@nih.gov
Inquiries regarding fiscal matters may be directed to:

Ms. Catherine Blount
Office of Administrative Management
National Cancer Institute
Executive Plaza South, Room 243
Bethesda, MD  20892
Telephone:  (301) 496-3179
FAX:  (301) 496-8601
Email:  cb136g@nih.gov

Direct inquiries regarding review matters to:

Ms. Toby Friedberg
Division of Extramural Activities
National Cancer Institute
6116 Executive Boulevard, Room 8062
MSC/8329
Bethesda, MD  20892-8329
Rockville, MD  20852 (for express/courier service)
Telephone:  (301) 496-3428
FAX:  (301) 402-0275
Email:  tf12w@nih.gov

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance No. 
93.398 Cancer Research Manpower.  Awards are made under authorization of the 
Public Health Service Act as amended by Sections 301 and 405 of the (42 USC 
241 and 284) and administered under NIH grants policies and Federal 
Regulations 42 CFR 52 and 45 CFR Parts 74 and 92.  This program is not 
subject to the intergovernmental review requirements of
Executive Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a 
smoke-free workplace and promote the non-use of all tobacco products.  In 
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking 
in certain facilities (or in some cases, any portion of a facility) in which 
regular or routine education, library, day care, health care or early 
childhood development services are provided to children.  This is consistent 
with the PHS mission to protect and advance the physical and mental health of 
the American people.


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