ESTABLISHED INVESTIGATOR AWARD IN CANCER PREVENTION, CONTROL, BEHAVIORAL AND 
POPULATION RESEARCH (K05)

Release Date:  January 10, 2000 (see replacement PAR-03-149)

PA NUMBER:  PAR-00-039

National Cancer Institute

PURPOSE

The purpose of the National Cancer Institute (NCI) Established Investigator 
Award in Cancer Prevention, Control, Behavioral and Population Research(K05) 
is to provide established investigators protected time to devote to research 
and to act as mentors for new investigators.  The target candidates are 
outstanding established scientists who have demonstrated a sustained, high 
level of productivity, research accomplishments, and contributions to cancer 
prevention, control, behavioral and population CANCER research; and who can 
demonstrate the need to sustain an intensive research focus that will enhance 
the progress of their own  research and provide them greater opportunity to 
serve as mentors to new scientists.  The award provides salary support for an 
award period up to five years, and is renewable for one additional five year 
period.

The NCI is especially interested in training and retaining scientists who 
conduct high-quality research in cancer prevention, control, behavioral and 
populations sciences.  Accordingly, this award forms an important part of the 
NCI Strategic Training Plan to relieve researchers from administrative 
responsibilities and/or clinical responsibilities in order to help them focus 
on research and mentoring.

Examples of disciplines relevant to this Program Announcement (PA) include 
any aspect of human cancer prevention (modifiable risk factors, new animal 
models and extrapolation of these models to human cancer, genetic 
predisposition to cancer and detection of precursor lesions, chemoprevention 
trials in human populations, and behavioral research and behavioral 
intervention trials in cancer prevention), epidemiology (biochemical, 
genetic, molecular), biostatistics, human cancer genetics, human nutrition, 
behavioral and social sciences, health promotion, health services and health 
policy research; and medical decision analysis, survivorship and quality of 
life as they relate to cancer; and basic and applied research in the 
behavioral sciences that independently or in combination with biomedical 
approaches, reduces cancer risk, incidence, morbidity, and mortality across 
the lifespan and over the entire process of carcinogenesis from primary 
behavioral prevention in youth, to screening, treatment, and survivorship.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health 
promotion and disease prevention objectives of "Healthy People 2000," a 
PHS-led national activity for setting priority areas.  This PA, Established 
Investigator Award in Cancer Prevention, Control, Behavioral and Population 
Research, is related to the priority areas of  cancer and human resource 
development.  Potential applicants may obtain a copy of "Healthy People 2000" 
at http://odphp.osophs.dhhs.gov/pubs/hp2000 .

ELIGIBILITY REQUIREMENTS

Candidates must be established CANCER scientists with a strong track record 
of publications and successful competition for cancer research support.   
Candidates must have peer-reviewed, independent research support at the time 
of and during the entire duration of the award.  This support could include 
National Institutes of Health (NIH) awards (e.g., R01) or awards from other 
sources, as long as they are equivalent to NIH R01 type grants in complexity 
and duration.  Individuals holding small grants (e.g., R03s) or developmental 
grants (e.g., R21s) are not eligible.  However, scientists whose work is 
primarily theoretical may apply for this award in the absence of research 
grant support, if the institutional commitment includes stability of salary 
and research support. Candidates must have a record of supervising junior 
researchers.  Finally, candidates for this award must be able to demonstrate 
the need for protected time to advance their research careers and mentoring 
activities.

Applications may be submitted on behalf of candidates by domestic, 
non-Federal organizations, public or private, such as medical, dental, or 
nursing schools or other institutions of higher education.  Racial/ ethnic 
minority individuals, women, and persons with disabilities are encouraged to 
apply as principal investigators.  Candidates must be U.S. citizens or 
noncitizen nationals, or must have been lawfully admitted for permanent 
residence and possess an Alien Registration Receipt Card (I-151 or I-551) or 
some other verification of legal admission as a permanent resident.  
Noncitizen nationals, although not U.S. citizens, owe permanent allegiance to 
the U.S.  They are usually born in lands that are not states but under U.S. 
sovereignty, jurisdiction or administration. Individuals on temporary or 
student visas are not eligible.

A candidate for this award may not concurrently apply for any other PHS award 
that duplicates the provisions of this award.

MECHANISM OF SUPPORT

The Established Investigator Award in Cancer Prevention, Control, Behavioral 
and Population Research is a special NCI modification of the NIH Senior 
Scientist Award or K05 grant mechanism. Planning, direction, and execution of 
the program will be the responsibility of the candidate on behalf of the 
applicant institution. However, the institution must demonstrate a commitment 
to the candidate and the candidates goals for career development.  The 
project period may be for up to five years (at least three years are 
required) . Awards are renewable for one additional five year period if the 
candidate still meets the stated requirements.

RESEARCH OBJECTIVES

A.  Background:  In 1998, the National Cancer Institute completed major 
external reviews of its cancer prevention and control sciences programs.  The 
scientific experts conducting these reviews recommended strengthening the 
NCI-supported cancer prevention program by increasing support of research on 
modifiable risk factors, new animal models and extrapolation of these models 
to human cancer, genetic predisposition to cancer and detection of precursor 
lesions, chemoprevention trials in human populations, and behavioral research 
and behavioral intervention trials in cancer prevention.  Recommendations 
made by the scientific experts for research areas of emphasis in cancer 
control included basic behavioral and social research, communications and 
informatics, rehabilitation and survivorship, quality of life, screening 
research , and applied cancer control research which includes health services 
and health policy research.  These groups also recommended bringing senior 
scientists into the NCI for short periods of time to collaborate with the NCI 
researchers and program staff.

The cancer prevention and cancer control review groups independently 
identified the current level of support for training in cancer prevention and 
cancer control as being inadequate to take advantage of the new opportunities 
for reducing cancer incidence, morbidity and mortality.  The scientific 
experts on these review groups recommended expanding current NCI support of   
education/ training programs in cancer prevention and cancer control, and 
multidisciplinary training of basic and clinical scientists in highly 
interdisciplinary and collaborative environments.  Similar recommendations 
have been made by other NCI advisory groups.

The NCI Cancer Training Branch responded to these recommendations in 1998 
with the NCI Strategic Training Plan.  A major focus of this plan was to 
provide new training and career development opportunities for young 
investigators in the cancer prevention, control and population sciences.  
Additionally, to address the projected needs of the mentors for these young 
investigators, the strategic plan proposed the use of a career award grant 
mechanism to provide senior investigators “protected” time to stabilize their 
research programs and for mentoring new investigators.

B.  Program: The award provides five consecutive 12 month appointments.  At 
least 25 percent and up to 50 percent of the recipient's full-time 
professional effort must be devoted to the program and the remainder devoted 
to other research-related and/or teaching pursuits consistent with the 
objectives of the award.

C.  Environment:  The institution must have a well-established research and 
career development program in cancer prevention, control and the population 
sciences.  The institution must be able to demonstrate a commitment to the 
candidate as a productive, independent investigator. The candidate and 
institution must certify that the candidate will be released from other 
duties and be able to devote up to 50 percent effort (at least 25 percent) to 
achieve the research and mentoring objectives of this award.  The institution 
must also document an adequate pool of candidates for mentoring.

D.  Allowable Costs:
1. Salary:   The NIH will provide salary for the award recipient of up to the 
current Federal salary rate limit plus commensurate fringe benefits for up to 
50 percent effort.  The institution may supplement the NIH contribution up to 
a level that is consistent with the institution's salary scale.  
Institutional supplementation of salary must not require extra duties or 
responsibilities that would interfere with the purpose of the award. 
Recipients of this award may derive additional compensation for the effort 
associated with other federal sources or awards provided the total salary 
derived from all Federal sources does not exceed the current Federal salary 
rate limit and their total percent effort on all awards  does not exceed 100 
percent.  Direct salary is exclusive of fringe benefits and indirect costs/ 
facilities and administrative expenses.

The total salary requested must be based on a full-time, 12-month staff 
appointment and the level of effort proposed.  It must be consistent both 
with the established salary structure at the institution and with salaries 
actually provided by the institution from its own funds to other staff 
members of equivalent qualifications, rank, and responsibilities in the 
department concerned. If full-time, 12-month salaries are not currently paid 
to comparable staff members, the salary proposed must be appropriately 
related to the existing salary structure. The award will also provide fringe 
benefits on the calculated base salary at the established institutional rate.

2. Research Development Support:  It is expected that candidates for a K05 
award will have active, independent research support at the time of the award 
(see ELIGIBILITY REQUIREMENTS).  However,  the K05 award provides additional 
funds up to $25,000 per year for the following expenses:  (a) tuition, fees, 
and books related to career development; (b) research expenses, such as 
supplies, equipment and technical personnel; (c) statistical and 
computational services including personnel and computer time; and (d) travel 
to research meetings or training. 
 
3. Ancillary Personnel Support: Salaries for secretaries, technical, 
administrative assistants and other ancillary personnel are not allowed.

4. Facilities and Administration Costs:  These costs, which were formerly 
called indirect costs, will be reimbursed at 8 percent of modified total 
direct costs.

E.  Other Income: Fees resulting from clinical practice, professional 
consultation, or other comparable activities required by the research and 
research-related activities of this award may not be retained by the career 
award recipient.  Such funds must be assigned to the grantee institution for 
disposition by any of the following methods:

- The funds may be expended by the grantee institution in accordance with the 
NIH policy on supplementation of career award salaries and to provide fringe 
benefits in proportion to such supplementation.  Such salary supplementation 
and fringe benefit payments must be within the established policies of the 
grantee institution;
- The funds may be used for health-related research purposes;
- The funds may be paid to miscellaneous recipients of the U.S. Treasury.  
Checks should be made payable to the Department of Health and Human Services, 
NIH and forwarded to the Director, Division of Financial Management, NIH, 
Bethesda, Maryland 20892.  Checks must identify the relevant award account 
and reason for payment;
- Awardees may retain royalties and fees for activities such as scholarly 
writing, service on advisory groups, or honoraria from other institutions for 
lectures or seminars, provided these activities remain incidental and 
provided that the retention of such pay is consistent with the policies and 
practices of the grantee institution.

Usually, funds budgeted in an NIH-supported research or research training 
grant for the salaries or fringe benefits of individuals, but freed as a 
result of a career award, may not be rebudgeted.  The awarding component will 
give consideration to approval for the use of released funds only under 
unusual circumstances.  Any proposed retention of funds released as a result 
of a career award must receive prior written approval of the NIH awarding 
component. 

F.  Evaluation: In carrying out its stewardship of human resource related 
programs, the NIH may  request information essential to an assessment of the 
effectiveness of this program.  Accordingly, recipients are hereby notified 
that they may be contacted after the completion of this award for periodic 
updates on various aspects of their employment history, publications, support 
from research grants or contracts, honors and awards, professional 
activities, and other information helpful in evaluating the impact of the 
program.

G. Special Leave:  Leave to another institution, including a foreign 
laboratory and to the NCI, may be permitted if directly related to the 
purpose of the award.  Awardees planning a period of leave must submit a 
written request to the NCI  in advance of the leave.  This request must be 
countersigned by the appropriate business official at the new 
institution/facility.  This request must include the reasons for the leave; 
and must provide a description of the provisions that will be made to ensure 
that the awardee will be able to continue meeting the special requirements of 
this award for a suitable research environment and for opportunities to 
mentor junior investigators during the period of leave.  NCI staff  will 
review the request and notify the principal investigator and the grantee and 
new institutions of the results of this evaluation.  If the request is 
approved, support will continue during the leave period.  Parental leave will 
be granted consistent with the policies of the NIH and the grantee 
institution.

H. Termination or Change of Institution: When a grantee institution plans to 
terminate an award, the NCI must be notified in writing at the earliest 
possible time so that appropriate instructions can be given for termination.  
If the individual is moving to another eligible institution, career award 
support may be continued provided:

A new  application for a K05 award is submitted by the new institution;

All conditions of the award are met at the new institution;
                    
The period of support requested is no more than the time remaining within the 
existing award period; and

The new application is submitted far enough in advance of the requested 
effective date to allow the necessary time for NCI review.
Review of these materials is usually carried out by NCI staff.  However, 
depending upon the circumstances, the NCI may also require a review by an 
initial review group and/or the National Cancer Advisory Board.

The NIH may discontinue an award upon determination that the purpose or terms 
of the award are not being fulfilled. In the event an award is terminated, 
the Director of the NIH shall notify the grantee institution and career award 
recipient in writing of this determination, the reasons therefor, the 
effective date, and the right to appeal the decision.

A final progress report, invention statement, and Financial Status Report are 
required upon either termination of an award or relinquishment of an award in 
a change of institution situation.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

For research projects involving human subjects, it is the policy of the NIH 
that women and members of minority groups and their subpopulations must be 
included in all NIH supported biomedical and behavioral research projects 
involving human subjects unless a clear and compelling rationale and 
justification is provided that inclusion is inappropriate with respect to the 
health of the subjects or the purpose of the research.  This policy results 
from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43).  

All investigators proposing research involving human subjects should read the 
"NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical 
Research," which has been published in the Federal Register of March 28,1994 
(FR 59 14508-14513), and in the NIH Guide For Grants And Contracts of March 
18, 1994, Vol. 23, No 11. It is also available electronically at the 
following website address: 
http://grants.nih.gov/grants/guide/notice-files/not94-100.html .

Investigators may obtain copies from these sources or from the program staff 
or contact person listed under INQUIRIES.  Program staff may also provide 
additional relevant information concerning the policy.

INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of NIH that children (i.e., individuals under the age of 21) 
must be included in all human subjects research, conducted or supported by 
NIH, unless there are clear and compelling scientific and ethical reasons not 
to include them. This policy applies to all applications submitted in 
response to this Program Announcement.  All investigators proposing research 
involving human subjects should read the "NIH Policy And Guidelines On The 
Inclusion Of Children As Participants In Research Involving Human Subjects" 
that was published in the NIH Guide For Grants And Contracts, March 6, 1998 
and is available at the following website address: 
http://grants.nih.gov/grants/guide/notice-files/not98-024.html.

As part of the scientific and technical merit evaluation of the research 
plan, reviewers will be instructed to address the adequacy of plans for 
including children as appropriate for the scientific goals of the research, 
or justification for exclusion. 

APPLICATION PROCEDURES

Applications are to be submitted using the modifications of the instructions 
(see below) for Research Career Awards starting on page  IV of the Form PHS 
398 (last revised 4/98) grant application kit.  Applications will be accepted 
three times a year on or before the regular receipt dates for Research Career 
Awards, which are February 1, June 1 and October 1.  The Form PHS 398 is 
available at most institutional offices of sponsored research and from the 
Division of Extramural Outreach and Information Resources, National 
Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 
20892-7910, Phone (301) 435-0714, FAX: (301) 480-0525, Email: 
grantsinfo@nih.gov.  Forms are also available on the following NIH website:  
http://grants.nih.gov/grants/funding/phs398/phs398.html.

All applications and proposals for NIH funding must be self-contained within 
specified page limitations.  Unless otherwise specified in an NIH 
solicitation, internet addresses (URLs) should not be used to provide 
information necessary to the review because reviewers are under no obligation 
to view the Internet sites.  Reviewers are cautioned that their anonymity may 
be compromised when they directly access an Internet site (see  
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-004.html).

Submit a signed, typewritten original of the application with Checklist, and 
three signed photocopies, in one package to:

Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040 - MSC 7710 
Bethesda, MD  20892-7710 or 
Bethesda, MD  20817-7710 (for express/courier service)

At the time of submission, two additional copies of the application must be 
sent to:

Referral Officer
Division of Extramural Activities
National Cancer Institute
6116 Executive Blvd., Room 8062 – MSC 8329
Bethesda, MD 20892-8329
Rockville, MD 20852 (for express/courier service)

The special instructions in the Form PHS 398 application kit for Research 
Career Awards (pages IV-1 through IV-7 and page LL) are for “mentored” awards 
and do not entirely apply to the K05 award. Letters of Reference, information 
about the Career Development/Training Activities During Award, and Statement 
by Sponsor(s) are NOT REQUIRED.  Accordingly, the instructions below have 
been adapted to accommodate the Form PHS 398 and the special needs of the K05 
grant:

1.  Face Page: Use page AA as instructed in the Form PHS 398.  On line 1. 
provide a title of project that is representative of your research.  For line 
2, fill in the number and title of this program announcement.
 
2.  Description of Personnel: Use page 2-BB and prepare as instructed.  List 
only your name (i.e., the candidate/principal investigator)

3.  Table of Contents (adapted from page LL to accommodate the K05) to be 
organized as follows:

		Content                             Page Number

Section I: Basic Administrative Data

a.  Face Page
b.  Description/ Key Personnel
c.  Table of Contents
d.  Budget for Entire Proposed Period of Support (Form Page EE)
e.  Biographical Sketches (Form Page FF)
	- Principal Investigator
	- Others
f.  Other Support for Principal Investigator (Format Pages GG)
g.  Resources (Form Page HH)

Section II: Specialized Information

a.  Introduction to Revised Application
b.  The Candidate

	- Candidate’s Research Background
	- Candidate’s Mentoring Background
	- Career Goals and Objectives: Scientific Biography


c.  Career Development Objectives and Justification of the Need for this 
Award

d.  Environment and Institutional Commitment to Candidate

e.  Research Plan (Current, future studies)

            Percent Effort on this grant (K05) to be committed to Research
            Currently Supported Research:

	- Statement of Hypotheses and Specific Aims
	- Background, Significance, and Rationale
	- Preliminary Studies and Results
	- Research Design and Methods

             New Research to be Specifically Supported by this Grant (K05) 
	
            - Hypothesis and Specific Aims
            - Significance and Rationale
            - Research Design and Methods
            
f.  Mentoring Plan

            Percent Effort on this grant (K05) to be committed to Mentoring

           - kinds of and availability of candidates that will be recruited 
for mentoring
           - educational and research experiences that will be provided
           - specific role as mentor in preparing trainees for an independent
              research career in the prevention, control, behavioral and 
population sciences

g.  Human Subjects
h.  Vertebrate Animals
i.  Literature Cited
j.  Consortium/ Contractual Arrangements
k.  Consultants
l.  Appendix (Five collated sets.  No page numbering necessary)
Number of Publications (not to exceed six):
List of key items:

3.  Biographical Sketch: Since the K05 is an unmentored award, provide 
information for the candidate and other key personnel, using Form Page 6-FF 
and the Additional Instructions for the Form PHS 398 on Page IV-3.  List all 
education, professional degree and specialty training. 

4.  Other Support (Form PHS 398, Page IV-3): Please note that because the 
NCI’s use of the K05 grant mechanism requires that candidates have research 
support an Eligibility Requirement, this grant is not subject to “Just-in-
Time” reporting procedures.  Therefore, a candidate for a K05 award must have 
active research support at the time of and for the duration of the award.    
A listing of all sources of active research support and pending research 
support for the candidate’s research must be provided, following the format 
on Page 7 (Page GG) of the general instructions for the Form PHS 398.

5.  Candidate’s Background: See the modified Table of Contents above for 
topical headings.  The reviewers must have a clear view of your research 
background and your experience as a mentor in the field or fields relevant to 
prevention, control, behavioral and population sciences. With regard to the 
latter, it would be helpful to the reviewers to provide the number of years 
of mentoring experience, the capacity in which you served as a mentor (i.e., 
research advisor, research mentor, etc.) and the number of trainees you have 
mentored.  The reviewers would be able to develop a complete understanding of 
your success as a mentor if you describe the types of research that were 
conducted by the individuals you mentored and the proportion of individuals 
under your oversight who became independent investigators.

6.  Career Development Objectives and Justification for a K05 Award:  It is 
important to convey to the reviewers your reasons for needing protected time 
to continue a vital research program and continue to engage in the mentoring 
of new scientists.  It should be clear that this award will allow you to 
spend more time on research and mentoring and less time on administrative and 
clinical responsibilities for the institution.

7.  Environment and Institutional Commitment to the Candidate:  Use the 
instructions in Form PHS 398, Page IV-5.  Within this part of the 
application, it would be helpful to the reviewers to understand what duties 
and responsibilities in the institution that you are being relieved of to 
focus on research and mentoring AND how the institution will accommodate 
these activities with other staff.

8.  Research Plan (PHS Form 398, Page IV-6 and General Instructions, Pages 
15-16): 

It is important to indicate your percent effort on this K05 that will be 
devoted specifically to research.

A Research Plan is a REQUIRED component of the application.

a.  For most applicants (see ELIGIBILITY REQUIREMENTS), ongoing, preferably 
peer-reviewed research support, is required at the time of and throughout the 
duration of the K05 award:

There is no need to provide extensive detail with regard to ongoing, funded 
research.  Enough information should be provided in the areas of Hypothesis 
and Specific Aims; Background, Significance and Rationale; Preliminary 
Studies and Results; and Research Design and Methods to permit the peer 
reviewers to evaluate the extent, special features and general quality of 
your research activities.

b.  Proposed new research activities:

Describe in reasonable detail how this award will be used to help you refine 
your research skills and/or develop new directions for your research.  This 
should be presented as a Statement of Hypothesis and Specific Aims; 
Background, Significance and Rationale; and Research Design and Methods.  
This is an important part of the application because it will provide the main 
rationale and justification for your need to have “protected time” for 
research.

Although it is likely that most of the described research will be ongoing, 
when appropriate the candidate must ensure that the inclusion of women, 
members of minority groups and their subpopulations, and children, has been 
addressed in the development of the design for all ongoing  research.  The 
candidate must provide for each new research project proposed the information 
described in the General Instructions in PHS Form 398 on pages 16-17; and 
must provide documentation that these issues have already been adequately 
addressed in ongoing research.

9.  Mentoring Plan: 

It is important to indicate the percent effort on this K05 award that will be 
devoted specifically to mentoring.

A Mentoring Plan is a REQUIRED component of the application.

This plan should include a description of the availability of clinicians for 
mentoring, the previous training and specialization of these individuals, 
plans for recruitment and supervision, the types of educational and research 
experiences that will be provided, and the capacity in which the applicant 
for the K05 award will serve as a mentor.  

REVIEW CONSIDERATIONS

Applications will be assigned based on the established NIH referral 
guidelines.  Applications will be reviewed for completeness by the Center for 
Scientific Review and for responsiveness to this Program Announcement by NCI 
staff.  Incomplete and non-responsive applications will be returned to the 
applicant without further consideration.  Applications that are not eligible 
(See ELIGIBILITY REQUIREMENTS), as judged by NCI staff, will be returned 
without further consideration. Applications that are complete and responsive 
to the program announcement will be evaluated for scientific and technical 
merit by a peer review group convened by the Division of Extramural 
Activities of the National Cancer Institute.  As part of the initial merit 
review, all applications will receive a written critique and undergo a 
process in which only those applications deemed to have the highest 
scientific merit, generally the top half of applications under review, will 
be discussed, assigned a priority score, and receive a second level review by 
the National Cancer Advisory Board to ensure that the proposed program meets 
the broad programmatic needs of the National Cancer Institute and the 
National Cancer Program.

The following review criteria will be applied: 

Candidate:

Quality of the candidate’s academic and research record, and track record as 
a leader of a productive research program.
 
o  A demonstrated record of mentoring or training of investigators, or a 
demonstration of the capability to provide mentoring to beginning 
investigators.

o  Evidence of ongoing high-quality research in the cancer prevention, 
control, behavioral or population sciences and the relationship of that 
research to the proposed K05 program.

o  A strong track record of obtaining research support in the cancer 
prevention, control, behavioral or population sciences.

Career and research plan:

o  Appropriateness of the research plan as a vehicle for developing and 
refining skills and capabilities in cancer prevention, control, behavioral 
and population sciences research.

Scientific and technical merit of the ongoing and newly proposed research.

Likelihood of research contributing significantly to the scientific knowledge 
base

o  Appropriateness of the duration of the proposed research program.

o  Availability of adequate resources to conduct the research program.

o  Demonstration that the proposed program and protected time will relieve 
the candidate of existing administrative (and where appropriate, clinical) 
duties to permit additional time for research.

o  Appropriateness of proposed level of effort committed to the Research 
Plan.

o  Adequacy of the plan's attention to gender and minority issues associated 
with projects involving human subjects.

o  Adequacy of plans for including children as appropriate for the scientific 
goals of the research, or justification for exclusion.

Mentoring Plan:

o  Experience and potential of the candidate to serve as a mentor.

o  Adequacy of the plans for mentoring or supervising junior investigators in 
cancer prevention, control, behavioral or population sciences research.

o  Appropriateness of the proposed level of effort committed to the Mentoring 
Plan.

Environment and Institutional Commitment:

o  Applicant institution's commitment to the scientific development of the 
candidate and assurances that the institution intends the candidate to be an 
integral part of its research program.

o  Quality and relevance of the environment for scientific and professional 
development of the candidate and trainees pursuing research in cancer 
prevention, control, behavioral and the population sciences;

Adequacy of the applicant institution's commitment to provide protected time 
for conduct of the research and mentoring programs.

AWARD CRITERIA

Applications will compete for available funds with all other scored career 
award applications received in response to this PA.  Funding decisions will 
be made based on the recommendations of the initial review group and the 
National Cancer Advisory Board, the need for research personnel in specific 
program areas, and the availability of funds. 

INQUIRIES

Written and telephone inquiries concerning this PA are encouraged especially 
during the planning phase of the application.  Below is a listing of the NCI 
staff in the  program,  grants management and review who are available for 
inquiries:

Direct inquiries regarding scientific or programmatic issues to:

Dr. Brian W. Kimes
Cancer Training Branch
Office of Centers, Training and Resources
National Cancer Institute
6116 Executive Blvd, Suite 7001
MSC 8346
Bethesda, MD  20892-8345
FAX:  (301) 402-0181
Email: bk34t@nih.gov

Direct inquiries regarding fiscal or budget matters to:

Ms. Catherine Blount
Grants Administration Branch
National Cancer Institute
Executive Plaza South, Room 243
Bethesda, MD 20892
Telephone: (301)-496-3179
FAX: (301)-496-8601
Email: cb136g@nih.gov

Direct inquiries regarding review matters to:

Ms. Toby Friedberg
Referral Officer
Division of Extramural Activities
National Cancer Institute
6116 Executive Blvd., Room 8062
MSC/8329
Bethesda, MD 20892-8329
Rockville, MD 20850 (express courier) 

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance No. 
93.398, Cancer Research Manpower.  Awards are made under authorization of 
Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 
and 284) and administered under PHS  grants policies and Federal Regulations 
42 CFR 52 and 45 CFR Part 74 and Part 92.  This program is not subject to the 
intergovernmental review requirements of Executive Order 12372 or Health 
Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a 
smoke-free workplace and promote the non-use of all tobacco products.  In 
addition, Public law 103-227, the Pro-Children Act of 1994, prohibits smoking 
in certain facilities (or, in some cases, any portion of a facility) in which 
regular or routine education, library, day care, health care or early 
childhood development services are provided to children.  This is consistent 
with the PHS mission to protect and advance the physical and mental health of 
the American people.


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