Full Text PA-94-059 BASIC RESEARCH IN EMOTION NIH GUIDE, Volume 23, Number 16, April 29, 1994 PA NUMBER: PA-94-059 P.T. 34 Keywords: Emotional/Mental Health Psychology National Institute of Mental Health National Institute on Aging National Institute of Child Health and Human Development PURPOSE Under this program announcement, the National Institute of Mental Health (NIMH), the National Institute on Aging (NIA), and the National Institute of Child Health and Human Development (NICHD) invite research grant applications to expand basic research on the processes and mechanisms involved in the experience and expression of emotion. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This program announcement, Basic Research in Emotion, is related to the priority area of mental health and mental disorders. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by public and private non-profit and for-profit organizations such as universities, colleges, hospitals, laboratories, research institutions, units of State or local governments, and eligible agencies of the Federal Government. Foreign institutions are not eligible for First Independent Research Support and Transition Award (FIRST) (R29) awards. Women and minority investigators are encouraged to apply. MECHANISMS OF SUPPORT In order to encourage increased research, applications are requested under the following mechanisms: research project grant (R01), small grant (R03, NIMH only), and FIRST award (R29). Eligibility and requirements for different funding mechanisms vary. Applicants are advised to contact NIMH, NIA, or NICHD program staff listed under INQUIRIES for additional information and specific application procedures. For research in method development, the small grant (R03) is a particularly appropriate mechanism; investigators may also choose to include method development as one component within research project grant (R01) applications. Support may be requested for a period of up to five years, except for small grants (R03), which are limited to two years. FIRST awards must be requested for five years. Annual noncompeting awards will be made subject to continued availability of funds and progress achieved. RESEARCH OBJECTIVES The study of emotion encompasses a wide range of psychological, social, and biological phenomena, including subjective feeling states, characteristic expressive signals, and alterations in physiology. The neural correlates of emotion and the role of cognitive processing in emotion also are important objects of study. In addition, the study of emotion includes overt behavioral responses such as aggression or withdrawal, interpersonal relationships and communication, and environmental circumstances and experiences that elicit and shape emotion. Recent years have shown the rapid expansion of concepts and methods for studying emotion in all of its aspects. Outlined in this program announcement are current needs that build on these advances and that constitute critical components of a comprehensive basic research strategy, with the ultimate aim of fostering mental health and the understanding of human development. These needs include a fuller description of the basic mechanisms of emotions and moods and the evolution of individual differences in emotional experience and expression. They include developmental approaches that incorporate examination of both phylogenetic and ontogenetic processes and that expand their focus to cover the lifespan. They call for new and increasingly precise methods and techniques for assessing emotion and its subjective, expressive, autonomic, and neural components. Finally, they explicitly consider both genetic and experiential factors in shaping emotional processes central to mental health, and take seriously the complex interactions and interrelationships that exist among social, psychological, and biological processes. Sample research questions are provided for illustrative purposes; they are not intended to be exhaustive. Basic Mechanisms of Emotion To foster the rapid and orderly accumulation of knowledge related to emotion, it is important that common criteria be adopted for defining emotion and its constituent components. The definition of the limits of "normal" emotion, in contrast with emotional responses seen in mental disorder, also is critical. A more detailed understanding is needed of the interplay between emotion and cognition that can inform conceptualizations of disorders in which impairments of both emotion and cognition are apparent (e.g., schizophrenia, depression), as well as provide data important for promoting emotional self-regulation and the voluntary control of emotional reactions. Sample research questions include, but are limited to, the following: o What are the necessary criteria that define emotion? Must the subjective, expressive, and physiological components always be present for emotion to occur? What is the timing among the components? What are the biological or psychological consequences of the inhibition of one or more components? o What are the continuities across, and distinctions among, the phenomena of reflex, emotion, mood, emotional trait, and emotional disorder? What social, psychological, and biological factors mediate their interrelationships? o What are the connections and bifurcations between normative emotional processes (e.g., emotional development, expression, understanding, awareness, communication) and psychopathology or resiliency? o How does attention act to sustain or interrupt emotional states? Individual Differences Research is suggesting that emotion-based individual differences may mark specific vulnerabilities to mental disorder; the detailed examination of these individual differences is critical for understanding etiology and for designing prevention efforts. In- depth study is needed of the determinants, consequences, and sequelae of infant temperament. Research in adult personality variation also is beginning to examine individual differences in emotional responsivity, with some indications of connections to physiology. Sample research questions include, but are not limited to, the following: o What are the biological and experiential sources of individual differences in emotional reactivity and regulation? o How do individual differences in emotionality relate to phenomena such as activity level, attention, and cognitive processes? What are the neural substrates that underlie relationships among such phenomena? o What biological, social, and cognitive factors interact with emotion-based individual differences to contribute to psychopathology? Developmental Aspects Data are accumulating rapidly in areas such as children's understanding and experience of emotions, and in emotional communications occurring between parents and children beginning in the earliest weeks of life. The impact and import of findings related to the development of emotions would be well served by an overarching theoretical framework specifying the ontogeny of emotion. Also, the primary concentration to date on the early years of life needs to be broadened to include focused attention on adolescence, adulthood, and old age. Sample research questions include, but are not limited to, the following: o Are connections among subjective, expressive, and physiological components of emotion present at birth? Do they change with age, particularly during periods of dramatic change (e.g., adolescence)? o What are the determinants, age-specific characteristics, and consequences of emotional attachments across the lifespan? What are the parallels among attachment patterns in infancy, in adolescence, in adulthood, in old age? o What affective processes are relevant to coping with events in the family life cycle, e.g., marriage, transition to parenthood, aging, dealing with death and bereavement? Social Aspects The quality of interpersonal relationships can play a significant role in the development of mental disorder. Further, in the presence of mental disorder, one's own and others' emotional reactions to the disorder itself can contribute to stigmatization that influences the probability of help-seeking as well as commitment to treatment. Similarly, the accuracy with which emotional signals are perceived and interpreted by others is a likely factor in the recognition of mental disorder and in the assessment of symptom improvement. In addition to the need for further research on these interpersonal aspects of emotion, it is very important to examine the macro-environmental processes (e.g., culture, social structure, the media) that help to shape emotional norms. Sample research questions include, but are not limited to, the following: o How do cultural and socialization processes influence the experience and expression of emotion, and what are the limits of this influence? How do salient social contexts in particular developmental stages (e.g., in adolescence: solitude, romantic and/or sexual relationships, neighborhoods) shape affective development and expression? o What are the dynamics of emotional communications occurring within families and other intimate groups? How do patterns of emotional communication relate to the development, maintenance, or erosion of emotional bonds and attachments? o How does parental behavior (e.g., teaching, limit- setting) influence the development of affect regulation in children? Biological Aspects Research has suggested that emotional experiences can be potent regulators of physiological homeostasis. The study of emotion provides a valuable opportunity for examination of the interplay between psychological, physiological, and neural processes, and methods are increasingly becoming available for examining the substrates of emotion in both the central nervous system (CNS) and autonomic nervous system (ANS). Sample research questions include, but are not limited to, the following: o What are the bidirectional influences between emotional states or emotional traits (e.g., temperament) and endocrine and immune systems? What are the neuroendocrinological mechanisms that account for the influence of emotion on physiological regulation and homeostasis? o What are the neuroanatomical and neurochemical processes involved in emotional states and emotion-based individual differences? What are the continuities and discontinuities of these processes across the lifespan? o What are the comparabilities across human and non-human emotional systems that define the limits of generalizability of animal studies to humans? Methodological Needs Methods related to the study of emotion run the full range from self-report and interview procedures to behavioral observations and to measures of ANS and CNS structure and function. Improvements are needed in ways that enhance validity and efficiency of measurement without sacrificing richness and detail. Sample needs include, but are not limited to: o Most research on emotional expression concentrates on the face. Methods also are needed to assess vocal, postural, and gestural components of emotional expression. Further, measures of emotion need to be developed that can be applied across cultures and species. o Techniques of computer science, neural networks, and image processing need to be applied to the task of producing valid and reliable judgments of facial and other behavioral expressions of emotion. o Expanded and improved neuroimaging techniques are needed to examine the correlates of emotion in brain function and anatomy. o Animal models need to be used to their fullest potential to examine social and biological determinants and consequences of emotion. STUDY POPULATIONS INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification is provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This new policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43) and supersedes and strengthens the previous policies (Concerning the Inclusion of Women in Study Populations, and Concerning the Inclusion of Minorities in Study Populations) which have been in effect since 1990. The new policy contains some new provisions that are substantially different from the 1990 policies. All investigators should read the "NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical Research", which have been published in the Federal Register of March 9, 1994 (FR 59 11146-11151), and reprinted in the NIH GUIDE FOR GRANTS AND CONTRACTS of March 18, 1994, Volume 23, Number 11. Investigators may obtain copies from these sources or from the program staff or contact persons listed below. Program staff may also provide additional relevant information concerning the policy. APPLICATION PROCEDURES Applicants are to use the grant application form PHS 398 (rev. 9/91). Application kits are available at most institutional offices of sponsored research and may be obtained from the Office of Grants Information, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone (301) 710-0267. The number and title of this program announcement, PA-94-059, Basic Research in Emotion, must be typed in item number 2a on the face page of the PHS 398 application form. FIRST applications must include at least three sealed letters of reference attached to the face page of the original application. FIRST applications submitted without the required number of reference letters will be considered incomplete and will be returned without review. Research applications (R01, R29, R03) will be accepted in accordance with the receipt dates indicated in the PHS 398 application kit. The receipt dates for applications for AIDS-related research also are found in the application kit. REVIEW CONSIDERATIONS Applications received under this program announcement will be assigned to an initial review group (IRG) in accordance with established PHS Referral Guidelines. The IRGs, consisting primarily of non-Federal scientific and technical experts, will review the applications for scientific and technical merit. Notification of the review recommendations will be sent to the applicant after the initial review. Applications (except those for small grants) will receive a second-level review by the appropriate National Advisory Council. Review Criteria Criteria for scientific/technical merit review of research applications will include the following: o Significance and originality from a scientific or technical standpoint of the goals of the proposed research o Adequacy of the methodology proposed to carry out the research o Feasibility of the proposed research o Qualifications and research experience of the principal investigator and other key research personnel o Availability of adequate facilities, other resources, and collaborative arrangements necessary for the research o Appropriateness of budget estimates for the proposed research activities o Adequacy of inclusion of women and minority subjects o Adequacy of provisions for the protection of human subjects and the welfare of animal subjects, as applicable. AWARD CRITERIA Applications recommended by the appropriate National Advisory Council will be considered for funding on the basis of overall scientific and technical merit of the research, as determined by peer review, Institute program needs and balance, and availability of funds. INQUIRIES Written and telephone inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Address inquiries regarding programmatic issues to: Lynne C. Huffman, M.D. Division of Neuroscience and Behavioral Science National Institute of Mental Health 5600 Fishers Lane, Room 11C-10 Rockville, MD 20857 Telephone: (301) 443-3942 FAX: (301) 443-4822 E-mail: L3H@NIHCU.BITNET Richard Nakamura, Ph.D. Division of Neuroscience and Behavioral Science National Institute of Mental Health 5600 Fishers Lane, Room 11-102 Rockville, MD 20857 Telephone: (301) 443-1576 FAX: (301) 443-4822 E-mail: NRN@NIHCU.BITNET Ronald P. Abeles, Ph.D. Behavioral and Social Research Program National Institute on Aging Gateway Building, Room 533 7201 Wisconsin Avenue Bethesda, MD 20892 Telephone: (301) 496-3136 FAX: (301) 402-0051 E-mail: RAS@NIHCU.BITNET Deborah Claman, Ph.D. Neuropsychology and Neurosciences Program National Institute on Aging Gateway Building, Room 3C-307 7201 Wisconsin Avenue Bethesda, MD 20892 Telephone: (301) 496-9350 FAX: (301) 496-1494 E-mail: CLAMAN@NIHNIAGW.BITNET Sarah L. Friedman, Ph.D. Human Learning and Behavior Branch National Institute of Child Health and Human Development Building 6100, Room 4B05 Bethesda, MD 20892 Telephone: (301) 496-6591 FAX: (301) 402-2085 E-mail: SF2@NIHCU.BITNET Norman A. Krasnegor, Ph.D. Human Learning and Behavior Branch National Institute of Child Health and Human Development Building 6100, Room 4B05 Bethesda, MD 20892 Telephone: (301) 496-6591 FAX: (301) 402-2085 E-mail: NXK@NIHCU.BITNET G. Reid Lyon, Ph.D. Human Learning and Behavior Branch National Institute of Child Health and Human Development Building 6100, Room 4B05 Bethesda, MD 20892 Telephone: (301) 496-6591 Address inquiries regarding fiscal matters to: Diana Trunnell Grants Management Branch National Institute of Mental Health 5600 Fishers Lane, Room 7C-08 Rockville, MD 20857 Telephone: (301) 443-3065 Vicki Maurer Grants Management Office National Institute on Aging Gateway Building, Room 2N-212 7201 Wisconsin Avenue Bethesda, MD 20892 Telephone: (301) 496-1472 Donald Clark Grants Management Branch National Institute of Child Health and Human Development 6100 Executive Boulevard, Room 8A01C Rockville, MD 20852 Telephone: (301) 496-5001 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance 93.242, 93.281, 93.282, 93.865, and 93.866. Awards made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78- 410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 42 CFR Part 66. This program announcement is not subject to the intergovernmental review requirements of Executive Order 12372, as implemented through DHHS regulations at 45 CFR Part 100, or Health Systems Agency review. .
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