Full Text PA-93-016

MOLECULAR AND CELLULAR BIOLOGY OF METASTATIC TUMOR CELLS

NIH GUIDE, Volume 21, Number 41, November 13, 1992

PA:  PA-93-016

P.T. 34

Keywords: 
  Cancer/Carcinogenesis 
  Biology, Cellular 
  Biology, Molecular 


National Cancer Institute

PURPOSE

The National Cancer Institute (NCI) invites exploratory/developmental
grant applications to study the molecular and cellular biology of
metastatic tumor cells.  This special initiative is designed to promote
collaborations and facilitate scientific interchange between
investigators, one with experience in the biology of metastasis and the
other in a more basic scientific discipline such as molecular or
cellular biology, or biochemistry.  Therefore, prospective Principal
Investigators need to identify a research collaborator.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This Program
Announcement (PA), Molecular and Cellular Biology of Metastatic Tumor
Cells, is related to the priority area of cancer. Potential applicants
may obtain a copy of "Healthy People 2000" (Full Report: Stock No.
017-001-00474-0) or "Healthy People 2000" (Summary Report:  Stock No.
017-001-00473-1) through the Superintendent of Documents, Government
Printing Office, Washington, DC 20402-9325  (telephone 202-783-3238).

ELIGIBILITY REQUIREMENTS

Applications may be submitted by foreign and domestic, for-profit and
non-profit organizations, public and private, such as universities,
colleges, hospitals, laboratories, units of State and local
governments, and eligible agencies of the Federal government.
Applications from minority individuals and women are encouraged.

MECHANISM OF SUPPORT

Support of this program will be through the National Institutes of
Health (NIH) exploratory/development research grant (R21).  Applicants
will be responsible for the planning, direction, and execution of the
proposed project.  Awards will be administered under PHS policy as
stated in the Public Health Service Grants Policy Statement, DHHS
Publication No. (OASH) 90-50,000, revised October 1, 1990 and in this
PA.

The Exploratory/Developmental Research Grants program (R21) provides
limited funds for short-term research projects.  These grants provide
an opportunity for initiating studies that may be preliminary in
nature.  Research investigators in relevant fields are invited to apply
for these grants in order to develop preliminary data that could form
the basis of future research project grant (R01) applications.

The Principal Investigator must be accountable to the recipient
organization officials for the proper conduct of the project.  The
research collaborator must be named and time and effort listed on the
budget page.  The recipient organization is legally responsible and
accountable to the PHS for performance and financial aspects of the
grant-supported activity.

FUNDS AVAILABLE

The direct costs per year for each application funded by the NCI must
not exceed $50,000.  The total project period for applications
submitted in response to this PA may not exceed two years and is not
renewable.  Applicants are advised to contact other relevant funding
components regarding their funding policies.

RESEARCH OBJECTIVES

The goal of this initiative is to provide funds for preliminary
research projects that will form the basis of future R01 applications
to investigate metastasis.  The intent is to (1) foster collaborative
research between investigators with basic molecular and cellular
biological and biochemical research experience, and those with
experience in metastasis research, and (2) increase the number of
laboratories and investigators addressing issues of metastasis.

The scope of the research may encompass the application of any aspect
of molecular and cellular biology and biochemistry to the investigation
of metastasis biology.  Applications should be for preliminary data
gathering or pilot feasibility studies, and should be founded on the
combined research experience of the Principal Investigator and his/her
collaborator.  The application should specifically address how the
application meets the intent of the initiative, e.g., the development
of a new collaboration between an investigator with basic molecular and
cellular biological and biochemical research experience and one with
experience in metastasis research.  Furthermore, the research
collaborator should address how the proposed research will relate to
and integrate with other ongoing research in his/her laboratory.  Just
as the initiative is intended to foster a research collaboration, the
application itself should clearly be the product of in-depth
discussions and input from both the research collaborator and the
Principal Investigator.

APPLICATION PROCEDURES

The research grant application form PHS 398 (rev. 9/91) is to be used
in applying for these grants.  Applications will be accepted at the
three regular application deadlines as indicated in the application
kit.  These forms are available at most institutional offices of
sponsored research; from the Office of Grant Inquiries, Division of
Research Grants (DRG), National Institutes of Health, Room 449,
Westwood Building, 5333 Westbard Avenue, Bethesda, MD 20892, telephone
301/496-7441; from the NCI Program Director named below.  The title and
number of the PA must be typed in section 2a on the face page of the
application.

The completed original application and five exact copies must be sent
or delivered to:

Division of Research Grants
National Institutes of Health
Westwood Building, Room 240
Bethesda, MD  20892

REVIEW PROCEDURE

Upon receipt, applications will be reviewed by the DRG for
completeness.  Incomplete applications will be returned to the
applicant without further consideration.  Those applications judged to
be complete will be further evaluated for scientific and technical
merit by study sections of the DRG.  Following the scientific and
technical review, the applications will receive a second level of
review by the appropriate national advisory council.

AWARD CRITERIA

Applications will compete for available funds with all other approved
applications.  The following factors will be considered when making
funding decisions:

o  Quality of the proposed project as determined by peer review
o  Availability of funds
o  Program balance among research areas of the PA.

The following additional factors will be considered for applications
assigned to the NCI:

o  In order to increase the number of laboratories and investigators
with potential for a long-term commitment to metastasis research,
preference in funding will be given to those investigators that are
early in their research careers

o  The extent to which the proposed research develops collaborations
that address the purpose of the initiative

o  How the proposed research relates to and integrates with other
ongoing research in the research collaborator's laboratory

INQUIRIES

Written and telephone inquiries are encouraged.  The opportunity to
clarify any issues or questions from potential applicants is welcome.

Direct inquiries regarding programmatic issues to:

Dr. Suresh Mohla
Chief, Cancer Biology Branch
National Cancer Institute
Executive Plaza South, Room 630
Bethesda, MD  20892
Telephone:  (301) 496-7028
FAX:  (301) 402-1037

Direct inquiries regarding fiscal and administrative issues to:

Robert Hawkins
Grants Management Branch
National Cancer Institute
Executive Plaza South, Room 243
Bethesda, MD  20892
Telephone:  (301) 496-7800 ext. 13

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance
No.93.396, Cancer Biology.  Awards are under authorization of the
Public Health Service Act, Title, IV, Part A (Public Law 78-410, as
amended by Public Law 99-158, 42 USC 241 and 285) and administered
under PHS grant policies and Federal Regulations 42 CFR 52 and 45 CFR
Part 74.  This program is not subject to the intergovernmental review
requirements of Executive order 12372 or Health Systems Agency review.


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