COLLABORATIONS FOR ADVANCED STRATEGIES IN OPPORTUNISTIC INFECTIONS - ADDENDUM

Release Date:  April 30, 1998

PA NUMBER:  PA-96-069

P.T.

National Institute of Allergy & Infectious Disease

Application Receipt Date:  September 1, 1998

This notice is an addendum to modify the RESEARCH OBJECTIVES AND SCOPE and
APPLICATION PROCEDURES of PA-96-069, COLLABORATIONS FOR ADVANCED STRATEGIES IN
OPPORTUNISTIC INFECTIONS, which was published in the NIH Guide for Grants and
Contracts, Vol. 25, No. 26, August 2, 1996.  It serves also to remind
investigators that September 1, 1998 is the final receipt date under this PA.

Research Objectives and Scope

This PA announces the interest of the NIAID in encouraging and supporting the
advanced preclinical research and clinical proof-of-concept strategies needed to
more effectively combat opportunistic infections that contribute to substantial
morbidity or mortality in HIV-infected individuals. This PA encourages
laboratory-based scientists and clinical investigators collaboratively to design
and propose multi-component research that has a common thematic goal for which
advanced preclinical data exist.

Though rapid declines in both the incidence of OIs and mortality rates have been
documented in HIV-infected persons since the introduction of highly active
antiretroviral regimens, the need continues to enhance prevention, detection, and
management of opportunistic infections when they occur.  Of increasing importance
is a better understanding of the specific HIV-associated immune defects that
render infected persons unable to prevent or overcome disease caused by specific
organisms and the extent to which effective immune function can be preserved or
restored by highly effective antiretroviral regimens or other means.

LETTER OF INTENT

The request for a letter of intent is withdrawn.

APPLICATION PROCEDURES

It is no longer necessary to send a copy of the application and appendices to Dr.
Dianne Tingley.

The completed original and five legible, single-sided copies of the application
and five sets of the appendices must be sent or delivered to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817-7710 (for express/courier service)

Review Criteria

The goals of NIH-supported research are to advance our understanding of
biological systems, improve the control of disease, and enhance health.  In the
written review, comments on the following aspects of the application will be made
in order to judge the likelihood that the proposed research will have a
substantial impact on the pursuit of these goals.  Each of these criteria will
be addressed and considered in the assignment of the overall score.

1.  Significance.  Does this study address an important problem?  If the aims of
the application are achieved, how will scientific knowledge be advanced? What
will be the effect of these studies on the concepts or methods that drive this
field?

2.  Approach.  Are the conceptual framework, design, methods, and analyses
adequately developed, well-integrated, and appropriate to the aims of the
project?  Does the applicant acknowledge potential problem areas and consider
alternative tactics?

3.  Innovation.  Does the project employ novel concepts, approaches or method? 
Are the aims original and innovative?  Does the project challenge existing
paradigms or develop new methodologies or technologies?

4.  Investigator.  Is the investigator appropriately trained and well suited to
carry out this work?  Is the work proposed appropriate to the experience level
of the principal investigator and other researchers (if any)?

5.  Environment.  Does the scientific environment in which the work will be done
contribute to the probability of success?  Do the proposed experiments take
advantage of unique features of the scientific environment or employ useful
collaborative arrangements?  Is there evidence of institutional support?

In addition, the adequacy of plans to include both genders, minorities and their
subgroups, and children as appropriate for the scientific goals of the research
will be reviewed.  Plans for the recruitment and retention of subjects will also
be evaluated.

INQUIRIES

Direct inquires regarding programmatic issues to:

Maureen Power, R.N., M.P.H.
Division of AIDS
National Institute of Allergy and Infectious Diseases
6003 Executive Boulevard, Room 2C41, MSC 7620
Bethesda, MD  20892-7620
Telephone:  (301) 402-3770
FAX:  (301) 402-3171
Email:  MP28S@NIH.GOV

Direct inquiries regarding fiscal and administrative matters to:

Ms. Jane W. Unsworth
Division of Extramural Activities
National Institute of Allergy and Infectious Diseases
6003 Executive Boulevard, Room 4B25, MSC 7610
Bethesda, MD  20892-7610
Telephone:  (301) 402-6824
FAX:  (301) 480-3780
Email:  JU3A@NIH.GOV

Inquiries should no longer be directed to Dr. Dianne Tingley.

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	Office of Extramural Research (OER)			National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892			Department of Health and Human Services (HHS)
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