NCRR COMPARATIVE MEDICINE RESEARCH AND RESOURCE GRANT SUPPORT NIH GUIDE, Volume 25, Number 12, April 19, 1996 P.T. 34 Keywords: Animal Breed. & Facil., Scientific Disease Model National Center for Research Resources With the recent reorganization of the National Center for Research Resources (NCRR) extramural programs that resulted in the Biological Models and Materials Research Program becoming a part of the Comparative Medicine area, the Comparative Medicine area is publishing this notice to restate its interests regarding the support of nonhuman primate resources, other special colonies of laboratory animals, and research and resource-related research projects for the development of animal (mammalian and nonmammalian) models. Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40) are used to provide support for special colonies of laboratory animals, including nonhuman primates, as well as for other resources such as cultures (cells, tissues, and organs) and genetic stocks that serve the biomedical research community at large. These resource centers must have three basic characteristics: (1) the resource must have a research component to generate new information which is relevant to the resource; (2) the resource must serve the needs of investigators in a variety of biomedical research areas where work is sponsored by NIH categorical Institutes; and (3) the resource must be available to investigators on a local, regional and national basis. Special colonies of research animals are defined as those animals that are valuable to biomedical research, but are not generally available because of problems of breeding, maintenance or procurement. Support for such colonies is usually limited to those used for a variety of research projects which span the interests of two or more categorical Institutes of the NIH. Grants for Regional Primate Research Centers (P51) support distinct organizational and structural components affiliated with major host academic institutions to provide the necessary specialized facilities, personnel, equipment, breeding colonies of nonhuman primates, and other core support needed by qualified investigators (local, regional, and national) to conduct independent and collaborative multi-categorical research programs. Regional Primate Research Centers (RPRC) were established to allow biomedical research to be carried out effectively using various species of nonhuman primates. Competition for a RPRC is open to extramural institutions that meet the required qualifications. To qualify, an applicant institution must already have in place the necessary infrastructure, including a well-established facility with a very strong ongoing research program supported by research grants from NIH and other funding agencies, specialized professional and support personnel, as well as an appropriate number and diversity of nonhuman primate species to compete for regional primate research center funding. Investigator-initiated research projects (R01 and R29) provide for the exploration and development of new models (including mammalian, nonmammalian, and mathematical and computer approaches) or for research to expand the usefulness of established model systems. Resource-related research projects (R24)provide for activities intended to enhance the capability of Comparative Medicine resources or that may lead to the development of a resource. All applications must be submitted on grant application form PHS 398 (rev. 5/95). Applications for projects under the R01, R24, R29, P40, and P51 mechanisms are accepted at the standard Division of Research Grants (DRG) receipt dates as published in the PHS 398 instructions. Since there are special instructions or guidelines for the preparation of resource center (P40 and P51) applications, prospective applicants are urged to consult with the Comparative Medicine Staff listed under INQUIRIES below. INQUIRIES For further information regarding this notice or to request special guidelines or instructions for NCRR Comparative Medicine resource center activities, contact: Dr. Leo A. Whitehair Director, Comparative Medicine National Center for Research Resources One Rockledge Centre, Suite 6030 6705 Rockledge Drive, MSC 7965 Bethesda, MD 20892-7965 Telephone: (301) 435-0744 Email: LeoW@EP.NCRR.NIH.GOV .
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