SMALL BUSINESS INNOVATION RESEARCH PROGRAM

NIH GUIDE, Volume 24, Number 33, September 22, 1995



P.T. 34



Keywords:

  Biomedical Research, Multidiscipl 



National Institutes of Health

Centers for Disease Control and Prevention

Agency for Health Care Policy and Research



Contract Proposal Receipt Date:  December 5, 1995



Innovative technologies and methodologies fuel progress in biomedical

and behavioral research and represent an increasingly important area

of the economy.  The Small Business Innovation Research (SBIR)

program provides support for research and development (R&D) of new

technologies and methodologies which have the potential to succeed as

commercial products.



The purpose of this notice is to (1) announce the issuance of the

SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS

INNOVATION RESEARCH (SBIR) CONTRACT PROPOSALS with a due date for

receipt of proposals of December 5, 1995; and (2) inform the public

about the opportunities that the SBIR program offers to small

business concerns as well as to scientists at research institutions,

including colleges and universities.  Public Law 102-564, dated

October 28, 1992, requires the Public Health Service (PHS),

Department of Health and Human Services, and certain other federal

agencies to reserve a specified amount of their extramural research

or R&D budgets for an SBIR program through fiscal year (FY) 2000.  In

FY 1996, 2.0 percent of the PHS extramural budget will be reserved

for the SBIR program, amounting to $180-$185 million (estimated); and

in FYs 1997 and beyond, the set-aside requirement will be 2.5

percent.



The offeror organization must be a small business concern, and the

PRIMARY EMPLOYMENT of the principal investigator MUST be with the

small business concern at the time of award and during the conduct of

the proposed project.  In accord with the intent of the SBIR program

to increase private sector commercialization of innovations derived

from federal R&D, scientists at research institutions can play an

important role in an SBIR project by serving as consultants and/or

subcontractors to the small business concern.  Normally, up to

one-third of the Phase I budget may be spent on consultant and/or

subcontractual costs, and up to one-half of the Phase II budget may

be spent on such costs.  In this manner, a small business concern

with limited expertise and/or research facilities may benefit from

teaming with a scientist(s) at a research institution; for the

scientist(s) at a research institution, this team effort provides

support for R&D not otherwise obtained.



The SBIR program consists of the following three phases:



PHASE I:  The objective of this phase is to determine the scientific

and technical merit and feasibility and potential for

commercialization of the proposed research or R&D efforts and the

quality of performance of the small business concern, before

consideration of further Federal support in Phase II.



PHASE II:  The objective of this phase is to continue the research or

R&D efforts initiated in Phase I.  Funding shall be based on the

results of Phase I and the scientific and technical merit and

commercial potential of the Phase II proposal.  Only Phase I

contractors are eligible to apply for Phase II funding, and Phase II

proposals may be submitted upon the request of the Contracting

Officer ONLY.



PHASE III:  The objective of this phase, where appropriate, is for

the small business concern to pursue, with non-SBIR funds, the

commercialization of the results of the research or R&D funded in

Phases I and II.



The amount and period of support for SBIR awards are as follows:



PHASE I:  Awards may not exceed $100,000 for direct costs, indirect

costs, and negotiated fixed fee for a period normally not to exceed

six months.



PHASE II:  Awards may not exceed $750,000 for direct costs, indirect

costs, and negotiated fixed fee for a period normally not to exceed

two years, that is, generally, a two-year Phase II project may not

cost more than $750,000 for that project.  Only one Phase II award

may be made for any SBIR project.



Following are the research topics contained in the SOLICITATION OF

THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH

(SBIR) CONTRACT PROPOSALS:



NATIONAL INSTITUTES OF HEALTH



NATIONAL INSTITUTE ON AGING (NIA)

o  Pharmacologic Manipulation of life span: Administration of 2-

deoxyglucose to mimic "anti-aging" effects of caloric restriction

o  Standardized Assessment of Doctor-Older Patient Interactions



NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM (NIAAA)

o  Computer Software for Use in Classifying Alcohol Use Disorders

o  Markers of Heavy Alcohol Consumption



NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

(NIDDK)

o  Improved Detection Methods for Immunolocalization of Low-Abundance

Proteins

o  Assays for Identification of High Risk Individuals for the

Development of Insulin Dependent Diabetes (IDDM)

o  Transplantation of Human Islets or Beta Cells

o  Development of Partial Estrogen Agonists With Beneficial Effects

on Bone

o  Gene Therapy for Diseases of Interest to NIDDK

o  Development of Materials for Screening and Recruitment of Clinical

Trial Participants

o  Self-study Materials for Achieving Intensive Management of

Glycemic Levels

o  Temporal and Spatial Control of Gene Activation/Inactivation

o  Methods to Detect and Quantify Kidney Damage

o  Selection and Marking Techniques for Hematopoietic Stem Cells

o  Expansion of the Numbers of Hematopoietic Stem Cells

o  Development of New Cytokines



NATIONAL INSTITUTE ON DRUG ABUSE (NIDA)

o  Telemedicine Technology for Drug Abuse and HIV Prevention Research

in Community Trials

o  Development of an Improved HIV Risk Assessment/Monitoring

Instrument for Use in Clinical Settings

o  Software Development of Integrated Research Tools

o  Drug Supply Services Support

o  Chemical Libraries for Drug Development

o  Analytical Services Support



NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES (NIEHS)

o  Development of deuterated nitroso spin traps for identifying

xenobiotic free radical metabolites

o  Development of methodologies for utilization of pathology tissue

specimens to obtain information on mechanistic bases of toxicologic

responses

o  Chromosome-specific DNA probes for non-human mammals

o  Automated scoring of sperm with FISH biomarkers

o  Development and use of protocols for identifying mutations in

mouse cells

o  Development of subchromosome painting kits for the mouse



NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH)

o  Antibodies to HIV-1 gp120: Detection in Formalin-Fixed Human Brain

o  Kits Combining PCR and Immunocytochemistry:  HIV-1 in Human Brain



NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS)

o  Animal Models

o  Non-Pharmacological Therapy of Epilepsy

o  Anti-Epileptic Drug Delivery Systems and Formulations

o  Portable Devices for Sleep Disorder Screening/Monitoring

o  EEG Home Monitoring for Infants

o  Near Infrared Spectroscopy (NIRS) for Monitoring of Cerebral

Oxygenation

o  Non-Pharmacological Therapy of Sleep Disorders

o  Fetal Magnetoencephalography to Assess Fetal Neurological

Integrity and Function

o  Models for Screening Antiepileptic Therapy

o  Application of Evoked Potentials to the Diagnosis of Sleep

Disorders

o  Development of "Virtual Reality" Goggles and Gloves for use in the

Administration of Cognitive Tasks



CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC)



NATIONAL CENTER FOR PREVENTION SERVICES (NCPS)

o  Develop Technology to Improve AIDS Reporting to State Health

Departments

o  HIV/AIDS Prevention Curriculum



PUBLIC HEALTH PRACTICE PROGRAM OFFICE (PHPPO)

o  Evaluation of Training Impact



AGENCY FOR HEALTH CARE POLICY AND RESEARCH (AHCPR)

o  Consumer Information

o  Software for Information Capture



INQUIRIES



Eligibility requirements, definitions, submission procedures, review

considerations, contract proposal forms and instructions, and other

pertinent information are contained in the SOLICITATION OF THE PUBLIC

HEALTH SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH (SBIR) CONTRACT

PROPOSALS available from:



PHS SBIR/STTR Solicitation Office

13687 Baltimore Avenue

Laurel, MD  20707-5096

Telephone:  (301) 206-9385

FAX:  (301) 206-9722

Email:  a2y@cu.nih.gov



In addition, the Solicitation is available electronically using

Business Gold, the National Technology Transfer Center's bulletin

board system.  Connect via Internet by telneting to "iron.nttc.edu"

or by dialing (304) 243-2560 for high speed modems (9600+) or (304)

243-2561 for 1200-2400 baud modems and logging in as "guest".  For

more information on their electronic bulletin board system, contact:



National Technology Transfer Center

Wheeling Jesuit College

316 Washington Avenue

Wheeling, WV  26003-6295

Telephone:  (800) 678-6882  (toll-free within U.S.)



Anyone interested in the PHS SBIR Grant program may obtain the

current edition of the OMNIBUS SOLICITATION OF THE PUBLIC HEALTH

SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH (SBIR) GRANT

APPLICATIONS from the above sources also.  See also the NIH Guide for

Grants and Contracts, Vol, 24, No. 3, January 27, 1995.



.

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