EVALUATION OF THE POTENTIAL OF 50/60 HZ MAGNETIC FIELDS IN PROMOTINGBREAST CANCER IN DMBA-TREATED FEMALE SPRAGUE DAWLEY RATS NIH GUIDE, Volume 24, Number 20, June 2, 1995 RFP AVAILABLE: NIH-ES-95-31 P.T. 34 Keywords: Toxicology 0715036 Health, Radiation Effects National Institute of Environmental Health Sciences The National Institute of Environmental Health Sciences (NIEHS) is soliciting proposals for studies designed to evaluate the potential of 50 Hz magnetic fields to promote mammary gland carcinogenesis in Sprague Dawley rats initiated with dimethylbenzanthracene (DMBA). The purpose of a 13-week study will be to replicate the series of studies reported by Loscher, that 50 Hz magnetic fields have the potential to increase the breast cancer rate in DMBA-treated female Sprague Dawley rats. The animals will be exposed to four weekly intragastric doses (5 mg/animal) of DMBA and magnetic fields of specified intensities and frequencies. The purpose of a 26-week study will be to determine whether or not 50 or 60 Hz magnetic fields can promote cancer in a standard DMBA model. The animals will be exposed to one intragastric exposure (10 mg/animal) of DMBA followed by exposures to 50 and 60 Hz magnetic fields of specified intensities for 26 weeks. This project may have three options: a 13-week study, a 26-week study, and a combination study where the 13- and 26-week studies are run concurrently. This project will be separated in two phases. Phase 1 will be the development phase, during which will occur the procurement of equipment and materials for the construction/renovation of the exposure and monitoring systems and the development effort needed to determine that the system functions appropriately. Phase 2 will be the initiation/promotion studies where one of the three options will be exercised. It is estimated that Phase 1 will require approximately 1.04 professional person-years per contract year and 0.24 technical person-years per contract year. Phase 2 will require approximately 1.9 professional person years and 3.4 technical person years for the 13-week study and 2.9 professional person-years and 5.5 technical person-years for the 26-week study. The estimated period of performance is 17 months. INQUIRIES Requests must reference Request for Proposals (RFP) No. NIH-ES-95-31. All responsible sources may submit a proposal that will be considered by the Agency. Requests for the RFP are to be directed to: Jo Ann Lewis Contracts and Procurement Management Branch National Institute of Environmental Health Sciences 79 T.W. Alexander Drive, Building 4401 Research Commons P.O. Box 12874 Research Triangle Park, NC 27709 Telephone: (919) 541-7893 FAX: (919) 541-2712 .
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