SMALL BUSINESS INNOVATION RESEARCH NIH GUIDE, Volume 24, Number 8, March 3, 1995 P.T. 34 Keywords: Contraceptives Chemical Synthesis 0740022 Immunology National Institute of Child Health and Human Development One program description for the Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) Grant and Cooperative Agreement Applications (PHS 95-3) was inadvertently omitted. The text, as it appears under the heading "B. Contraceptive Development" pertains to "C. Contraceptive and Reproductive Evaluation". Thus, on page 63, under "Contraceptive Development", the text should read as follows: B. Contraceptive Development Research focussed on new and improved methods of fertility regulation, for men and for women, that are safe, effective, inexpensive, reversible, and acceptable. The objective of the research is to develop an array of methods that couples in various population groups can use successfully and safely. (1) Synthesis and testing of drugs that can influence male and female fertility and that have the potential of becoming useful contraceptives. (2) Development of methods of contraceptive drug administration that can improve the bioavailability from different routes of administration. (3) Isolation of antigens specific to the reproductive system that could be utilized for antifertility vaccine development. (4) Development of improved barrier contraceptives for men and women, including new spermicidal agents or new formulations that may reduce vaginal irritation and provide better protection against sexually transmitted diseases. (5) Development of simplified methods to quantify sperm counts, particularly for men with low sperm counts. (6) Developing leads to non-peptide GnRH analogs (agonists and antagonists), as potential contraceptive agents, via screening of libraries of compounds against the GnRH receptor. C. Contraceptive and Reproductive Evaluation INQUIRIES For further information regarding this program, contact: Ms. Hildegard Topper National Institute of Child Health and Human Development Building 31, Room 2A03 Bethesda, MD 20892-2425 Telephone: (301) 496-0104 FAX: (301) 402-1104 Email: ht20t@nih.gov .
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