POTENTIAL FOR ENVIRONMENTAL AND THERAPEUTIC AGENTS TO INDUCEIMMUNOTOXICITY



NIH GUIDE, Volume 23, Number 40, November 18, 1994



RFP AVAILABLE:  NIH-ES-95-22



P.T. 34



Keywords:

  Toxicology 

  Immunology 

  Environmental Effects 



National Institute of Environmental Health Sciences



The National Institute of Environmental Health Sciences (NIEHS),

National Institutes of Health (NIH), is soliciting proposals from

offerors that have the capabilities and facilities to perform the

following tasks:  Task I, demonstrate proficiency in the performance

of the Immune Testing Assays provided by the Environmental Immunology

and Neurobiology Section (EINS) to detect chemical-induced immune

alteration.  The sub-task I-A Immunosuppression will involve

Immunopathology, Humoral Mediated Immunity, Cell Mediated Immunity,

Cell Quantification, Non-specific Immunity and Host Resistance Assays

and sub-task I-B Hypersensitivity Assays will involve Mouse ear

swelling test (MEST) and Local lymph node assay (LLNA).  Task II-A,

upon demonstration of proficiency, the contractor will test four

xenobiotics per year using tests described in Task I-A.  Task II-B,

the contractor will test two xenobiotics per year thereafter. Task

II-C the contractor will test two xenobiotics per year for their

potential to produce skin hypersensitivity in the mouse.  Task II-D,

the contractor will test one xenobiotic per year for the potential to

influence autoimmune disease.  Task III  - Development and/or

Evaluation of New and Improved Technology will be conducted beginning

in year two of the contract, e.g., to quantitate certain biomedical

changes.  The Government estimates that the project will require

approximately 1.5 professional person-years, 1.8 senior technical

person years and 1.0 technical person years per contract year.  The

estimated period of performance is five years.



INQUIRIES



All responsible sources may submit a proposal that will be considered

by the Agency.  Release of Request for Proposals (RFP) No. NIH-

ES-95-22 is anticipated on or about November 9, 1994 with proposals

due January 3, 1995.  Requests must reference the RFP number and must

be directed to:



Howard Hill

Contracts and Procurement Management Branch

National Institute of Environmental Health Sciences

79 T.W. Alexander Drive, Building 4401 Research Commons

P.O. Box 12874

Research Triangle Park, NC  27709

Telephone:  (919) 541-4971

FAX:  (919) 541-2712



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