SYNTHESIS AND TESTING OF NEW ANTIPROGESTATIONAL AGENTS NIH GUIDE, Volume 23, Number 29, August 5, 1994 RFP AVAILABLE: NICHD-CD-94-13 P.T. 34 Keywords: Chemical Synthesis Chemistry, Organic Contraceptives National Institute of Child Health and Human Development The Contraceptive Development Branch of the Center for Population Research, National Institute for Child Health and Human Development (NICHD) has a requirement for the synthesis and testing of antiprogestational agents as postcoital antifertility agents. The goals of this acquisition are to design, synthesize, and test antiprogestational agents that are at least ten-fold more potent orally than mifepristone in standard assays for antiprogestational activity in laboratory animals. The selected prototypes for further structural modification may be mifepristone or other leads that have demonstrated oral activity. Such antagonists should, desirably, also have minimal hormonal and other antihormonal activities for use as contraceptive agents. Such antiprogestational agents must also be devoid of effects on central nervous and cardiovascular systems. The Government will carry out in vivo biological assays required to establish the antiprogestational activity of compounds submitted to the Contraceptive Development Branch under the auspices of this acquisition. Offerors must undertake standard in vitro progesterone and glucocorticoid binding assays on all the newly synthesized compounds in house or through subcontracting. Specifically excluded from consideration are (a) inhibitors of progesterone biosynthesis, and (b) estrogens. Organizations must have adequate facilities and capabilities to carry out the proposed synthetic chemical program and in vitro binding assays as mentioned above. The Government estimates the effort to be approximately 4.9 technical person-years annually. The principal investigator must be a synthetic organic and/or medicinal chemist with a Ph.D. degree, who will devote approximately 25 percent of her/his time to the project and must have five years of experience in drug synthesis. All responsible sources may submit a proposal that will be considered by the agency. It is anticipated that four cost- reimbursement incrementally funded type contracts will be awarded as a result of the request for proposals (RFP) for a period of 36 months, beginning June 1, 1995. This announcement is not an RFP. RFP NICHD-CD-94-13 will be available on or about August 19, 1994. Proposals will be due approximately 120 days thereafter. INQUIRIES Requests for copies of the RFP must cite the RFP number and be addressed to: Paul J. Duska Office of Grants and Contracts National Institute of Child Health and Human Development 6100 Building, Room 7A07 Bethesda, MD 20892 FAX: (301) 402-3676 .
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