SYNTHESIS AND DEVELOPMENT OF NEW SPERMICIDES WITH MICROBICIDALPROPERTIES NIH GUIDE, Volume 23, Number 24, June 24, 1994 RFP AVAILABLE: NICHD-CD-94-14 P.T. 34 Keywords: Contraceptives Microbiology Chemistry, Organic Chemical Synthesis National Institute of Child Health and Human Development The Contraceptive Development Branch of the Center for Population Research, National Institute of Child Health and Human Development, is interested in stimulating investigations into the synthesis, testing, and development of novel spermicidal\anti-STD agents that inactivate human sperm and sexually transmitted disease (STD) pathogens, especially HIV, preferably via mechanisms other than the disruption of cell membranes. The spermicidal\anti-STD agent is defined as (1) an agent comprised of a single chemical entity possessing both spermicidal and anti-STD activity or (2) an agent that is comprised of two chemical entities, one possessing spermicidal activity and the other anti-STD activity. The goals are to obtain human spermicidal\anti-STD agents that (a) are equipotent with or more potent than nonoxynol-9 (N-9), (b) have a rapid onset of sperm inactivation equivalent to or greater than that of N-9, (c) do not cause vaginal irritation, (d) can inactivate STD pathogens while producing only a transient effect on normal human vaginal flora, (e) are miscible with human cervical mucus, (f) are inexpensive, and (g) are aesthetically pleasing (i.e., colorless, odorless). Such investigations will involve the synthesis and biological evaluation of the spermicidal\anti-STD agents by the contractor. This project requires both the expertise of a Ph.D. synthetic organic or medicinal chemist and a Ph.D. biologist. A collaborative effort (in-house or via subcontract arrangement) of such scientists is essential for the success of the project. Organizations must have adequate facilities to carry out the proposed syntheses and biological testing. The Government estimates the effort to be approximately 4.0 technical person-years annually. The principal investigator or co-principal investigators should devote approximately 20 percent effort to this project. All responsible sources may submit a proposal that will be considered by the agency. It is anticipated that five cost-reimbursement incrementally funded type contracts will be awarded as a result of the Request for Proposals (RFP) for a period of 36 months, beginning April 3, 1995. This announcement is not an RFP. RFP No. NICHD-CD-94-14 will be available on or about June 30, 1994. Proposals will be due approximately 90 days thereafter. INQUIRIES Requests for the RFP must cite the above RFP number. Copies of the RFP may be obtained by sending a written or FAX request to: Paul J. Duska Office of Grants and Contracts National Institute of Child Health and Human Development 6100 Building, Suite 7A-07 Bethesda, MD 20892 FAX: (301) 402-3676 .
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