APPLICATION OF DATA ON THE HLA SYSTEM TO THE DEVELOPMENT ANDIMPROVEMENT OF VACCINES AND INFLUENCE OF HLA AND OTHER GENES ON

RESPONSE TO VACCINES



NIH GUIDE, Volume 23, Number 1, January 7, 1994



RFP AVAILABLE:  BAA NIH-NIAID-DAIT/DMID-94-30



P.T. 34



Keywords:

  Vaccine 



National Institute of Allergy and Infectious Diseases



The Genetics and Transplantation Branch of the Division of Allergy,

Immunology and Transplantation, National Institute of Allergy and

Infectious Diseases, promotes and supports research leading to a

better understanding of the HLA system, the human major

histocompatibility system, including the identification, mapping, and

regulation of the HLA genes, the structure and function of the

products of the HLA genes, and the role of the HLA system in

regulating immune responses in health and disease.  The focus of Part

I of this Broad Agency Announcement is on basic research that will

serve to acquire the data necessary for developing new safe and

effective vaccines and for improving existing vaccines, for

developing improved methods for isolating, characterizing, and

assessing the immunogenic potential of HLA-bound peptides of

infectious agents, for developing improved methods for modifying

peptides and screening their potential for use in vaccines, for

defining the mechanisms underlying regulation of the response to

infection and vaccination by the HLA system, and to acquire knowledge

about the factors governing the interactions between peptide and HLA

molecules and between T cell antigen receptors and HLA-peptide

complexes.  Part II of this Broad Agency Announcement invites

offerors to submit proposals for conducting population research on

the role of products of HLA, T cell receptor, immunoglobulin,

cytokine, complement, and other genes, in responses to immunization.



BAA NIH-NIAID-DAIT/DMID-94-30 will be available on or about January

03, 1993, and proposals will be due approximately March 8, 1994.  It

is anticipated that more than one cost-reimbursement contract

covering one or more categories listed under the Research and

Technical Objectives will be awarded for a period up to five years.

This advertisement does not commit the government to award a

contract.



INQUIRIES



To receive a copy of this RFP, please supply two self-addressed

mailing labels.  All inquiries must be in writing and addressed to

the office below:



Rosemary McCabe Hamill

Contracting Officer

National Institute of Allergy and Infectious Diseases

Contracts Management Branch

Solar Building, Room 3C07

6003 Executive Boulevard

Bethesda, MD  20892



.


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