KIDNEY RESEARCH CENTERS

NIH GUIDE, Volume 21, Number 45, December 18, 1992



RFA AVAILABLE:  DK-93-09



P.T. 04



Keywords:

  Nephrology 

  Biology, Cellular 

  Biology, Molecular 

  Immunology 

  Genetics 

  Biomedical Research, Multidiscipl 



National Institute of Diabetes and Digestive and Kidney Diseases



Letter of Intent Receipt Date:  March 8, 1993

Application Receipt Date:  April 9, 1993



THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS

ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION.

POTENTIAL APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN

INQUIRES, BELOW.



PURPOSE



This RFA invites investigators to submit research applications for

the George M. O'Brien Research Centers Program.  The emphases for

this program are threefold:  (1) to attract new scientific expertise

into the study of the basic mechanisms of kidney diseases and

disorders; (2) to encourage multidisciplinary research focused on the

causes these diseases; and (3) to extend the development of

innovative clinical and epidemiologic studies of the causes, therapy

and possible prevention of kidney diseases and disorders.  In

approaching the study of these disease processes, it is anticipated

that extensive collaboration will be required between individuals in

the clinical and basic sciences, including, for example,

investigators with training and expertise in cell biology, molecular

biology, immunology, genetics, epidemiology, biochemistry,

physiology, and pathology.  It is the express intent of the

announcement to attract new investigators not currently active in

this field and to explore new basic areas that may have clinical

research applications.  Individual institutions with both basic and

clinical research capabilities are eligible to apply.

Interinstitutional collaborative research arrangements are also

appropriate and encouraged.  Coordination for such arrangements must

be evident and clearly meaningful and appropriate for the research

proposed.



HEALTHY PEOPLE 2000



The Public Health Service (PHS) is committed to achieving the health

promotion and disease prevention objectives of "Healthy People 2000,"

a PHS-led national activity for setting priority areas.  This RFA,

Kidney Research Centers, is related to the area of diabetes and other

chronic disabling conditions.  Potential applicants may obtain a copy

of "Healthy People 2000" (Full Report:  Stock No. 017-001-00474-0) or

Healthy People 2000" (Summary Report:  Stock No. 017-001-00473-1)

through the Superintendent of Documents, Government Printing Office,

Washington, DC 20402-9325 (telephone 202-783-3238).



ELIGIBILITY REQUIREMENTS



Applications may be submitted by domestic for-profit and nonprofit

organizations, public and private, such as universities, colleges,

hospitals, laboratories, units of State and local governments, and

eligible agencies of the Federal government.  Foreign institutions

are not eligible to apply.  Minority individuals and women are

encouraged to submit as principal investigators.



MECHANISM OF SUPPORT



Support of this program will be through the National Institutes of

Health (NIH) specialized center (P50) award.  Responsibility for the

planning, direction, and execution of the proposed project will be

solely that of the applicant.  Except as otherwise stated in this

announcement, awards will be administered under PHS grants policy as

stated in the PHS Grants Policy Statement.



FUNDS AVAILABLE



The NIDDK expects to award up to two center grants (P50) in FY 1993

for research into kidney disorders.  The anticipated awards are for

five years and are contingent upon the availability of appropriated

funds.  The total amount of available funds to support this program

is anticipated to be no more than $1.5 million per year.  No

applicant may request more than $750,000 (including both direct and

indirect costs) in total costs in the initial budget period.  A

standard escalation factor may be used for subsequent budget periods.

The award date for these grants will be September 30, 1993.



SPECIAL REQUIREMENTS



Successful applicants are expected to attend a yearly meeting of

Center Directors convened by the NIDDK.  Funds to support travel to

this meeting may be requested in the budget proposed for the center.



STUDY POPULATIONS



It is NIH policy that women and minorities must be included in

clinical study populations unless there is a good reason to exclude

them.  The study design must seek to identify any pertinent gender or

minority population differences.



SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH

POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL

RESEARCH STUDY POPULATIONS



For projects involving clinical research, NIH requires applicants to

give special attention to the inclusion of women and minorities in

study populations.  If women or minorities are not included in the

study populations, a specific justification for his exclusion must be

provided.  Applications without such documentation will not be

accepted for review.



LETTER OF INTENT



Prospective applicants are asked to submit, by March 8, 1993, a

letter of intent that includes a descriptive title of the proposed

research, the name, address, and telephone number of the Principal

Investigator, the identities of other key personnel and participating

institutions, and the number and title of the RFA in response to

which the application may be submitted.



A letter of intent is not required, is not binding, and does not

enter into the review of subsequent applications.



The letter of intent is to be sent to:



Chief, Review Branch

Division of Extramural Activities

National Institute of Diabetes and Digestive and Kidney Diseases

Westwood Building, Room 605

Bethesda, MD  20892

Telephone:  (301) 496-7083

FAX:  (301) 402-1277



APPLICATION PROCEDURES



The research grant application form PHS 398 (rev. 9/91) is to be used

in applying for these grants.  The form is available from most

institutional offices of sponsored research and from the Office of

Grants Inquiries, Division of Research Grants, National Institutes of

Health, 5333 Westbard Avenue, Room 449, Bethesda, Maryland 20892,

telephone 301/496-7441.



The RFA label available in the application form must be affixed to

the bottom of the face page.  Detailed instructions on submission

procedures are described in the RFA.



REVIEW CONSIDERATIONS



Upon receipt, applications will be initially reviewed for

completeness and responsiveness.  Incomplete applications or

non-responsive applications will be returned to the applicant without

further consideration.



Those applications that are complete and responsive will be evaluated

in accordance with the usual NIH peer review procedures.  Following

this review, the applications will be given a secondary review by the

NIDDK Advisory Council unless not recommended for further

consideration by the initial review group.



INQUIRIES



Written and telephone inquiries concerning this RFA are encouraged.



Inquiries regarding programmatic issues and requests for copies of

the RFA may be directed to:



Ralph L. Bain, Ph.D.

Director, Centers Program

Division of Kidney, Urologic, and Hematologic Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

Westwood Building, Room 3A-05

Bethesda, MD  20892

Telephone:  (301) 496-7574



Inquiries regarding fiscal matters may be directed to:



Ms. Helen Ling

Grants Management Specialist

Division of Extramural Activities

National Institute of Diabetes and Digestive and Kidney Diseases

Westwood Building, Room 649

Bethesda, MD  20892

Telephone:  (301) 496-7467



AUTHORITY AND REGULATIONS



This program is described in the Catalog of Federal Domestic

Assistance No. 93.849.  Awards are made under authorization of the

Public Health Service Act, Title IV, Part A (Public Law 78-410, as

amended by Public Law 99-158, 42 USC 241 and 285) and administered

under PHS grants policies and Federal Regulations 42 CFR 52 and 45

CFR Part 74.  This program is not subject to the intergovernmental

review requirements of Executive Order 12372 or Health Systems Agency

review.



.

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	Office of Extramural Research (OER)			National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892			Department of Health and Human Services (HHS)
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