DATA COORDINATION CENTER FOR COOPERATIVE COMMUNITY-BASED PERINATALSTUDIES AND INTERVENTIONS IN MINORITY POPULATIONS



NIH GUIDE, Volume 21, Number 43, November 27, 1992



RFA AVAILABLE:  HD/NR/OMP-93-010



P.T. 34, FF



Keywords:

  Data Management/Analysis+ 

  Children (Patients) 

  Prenatal Factors 

  Community/Outreach Programs 



National Institute of Child Health and Human Development

National Center for Nursing Research

Office of Minority Programs



Letter of Intent Receipt Date:  January 15, 1993

Application Receipt Date:  February 18, 1993



THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS

ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION.

POTENTIAL APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN

INQUIRIES, BELOW.



PURPOSE



The National Institute of Child Health and Human Development (NICHD),

in cooperation with the National Center for Nursing Research (NCNR)

and the Office of Minority Programs (OMP), invites applications for a

cooperative agreement to participate as the Data Coordination Center

(DCC) in support of planning and conducting research to address the

problem of the unacceptably high infant mortality rate among minority

populations in this country.  Specifically, the Institutes will

assist the community (using a cooperative agreement mechanism) in

establishing a model population based perinatal epidemiology and

clinical research effort to conduct research that is aimed at

increasing the understanding of the determinants of the high infant

mortality rate in Washington, DC, and developing and testing

interventions intended to reduce infant mortality and its related

outcomes, such as low birth weight, intrauterine growth retardation,

and preterm delivery.



A Data Coordination Center for the network of research organizations

established via a prior RFA (HD/NR/OMP-92-07) will provide management

support and consultation in the design, execution, and analysis for

multi-institutional observational and experimental studies in the

field of infant mortality, and will ensure that the studies are of

the highest scientific integrity and meet rigorous statistical

standards.  The Data Coordination Center will be functionally

independent of all research sites, although it could be physically

located at one of them.



HEALTHY PEOPLE 2000



The Public Health Service (PHS) is committed to achieving the health

promotion and disease prevention objectives of "Healthy People 2000,"

a PHS-led national activity for setting priority areas.  This RFA,

Data Coordination Center for Cooperative Community-Based Perinatal

Studies and Interventions in Minority Populations, is related to the

priority areas of infant mortality, fetal deaths, low birth weight,

high risk pregnancies, and prenatal care.  It is a component of the

Infant Mortality Initiative of the PHS and the Minority Health

Initiative of the National Institutes of Health (NIH).  Potential

applicants may obtain a copy of "Healthy People 2000" (Full Report:

Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report:

Stock No. 017-001-00473-1) through the Superintendent of Documents,

Government Printing Office, Washington, DC 20402-9325 (telephone

202/783-3238).



ELIGIBILITY REQUIREMENTS



Applications may be submitted by for-profit and non-profit

organizations, public and private, within easy commuting distance of

the District of Columbia.  Institutions may submit singly or in

partnerships with two or more organizations or groups.



MECHANISM OF SUPPORT



The funding mechanism to be used to assist the community in

undertaking this coordinated population-based research effort,

including behavioral interventions and clinical trials, will be the

research demonstration cooperative agreement (U18).  This cooperative

agreement provides support for testing, by means of a research

design, the effectiveness of the transfer and application of

techniques or interventions derived from a research base for the

control of diseases or disorders, or for the promotion of health.

The project should be capable of making conclusions which are

generally applicable to other sites.



The major difference between a cooperative agreement and a research

project grant is that there will be substantial programmatic

involvement of the NICHD Project Coordinator above and beyond the

levels required for traditional program management of grants.

(Grants Policy Statement, DHHS Publication (OASH) 90-50,000 (rev.

10/01/91)).  Specifically, a member of the NICHD scientific staff

will cooperate with Principal Investigators as a partner in the

projects and serve as the Project Coordinator.  All parties will

agree to accept the participatory and cooperative nature of the group

process.  Since the OMP and the NCNR are cosponsoring this

initiative, NCNR and OMP representatives will also participate as

partners.



FUNDS AVAILABLE



The estimated funds available for support of the entire program for

the first year of the initiative (covered by a prior RFA), which will

consist primarily of planning and protocol development, are $500,000

total costs.  Supplemental funds will be added in future years to

cover costs of the implementation and evaluation of protocols.  Due

to the reissuing of this RFA, no Data Coordination Center costs will

be incurred for the first year of the initiative (FY 92).  The FY 93

budget has appropriated up to $5,000,000 total cost for this purpose

(for both the DCC and the six sites) for FY 93 (year 02 of the

initiative).  It is estimated that Data Center costs could be up to

$345,000 for year 01 for this award (Years 02/03 of the initiative).

One award will be made for the Data Coordination Center.  Although

this program is provided for in the financial plans of the

participating organizational entities, the award of a grant pursuant

to this RFA is also contingent on the availability of funds for this

purpose.



APPLICATION PROCEDURES



The research grant application form PHS 398 (rev. 09/91) is to be

used in applying for these grants.  These forms are available at most

institutional offices of sponsored research and from the Office of

Grants Inquiries, Division of Research Grants, National Institutes of

Health, 5333 Westbard Avenue, Room 449, Bethesda, MD 20892, telephone

301/496-7441.



The RFA label available in the PHS 398 application form must be

affixed to the bottom of the face page of the application.  Failure

to use this label could result in delayed processing of the

application such that it may not reach the review committee in time

for review.  In addition, the RFA title and number must be typed on

line 2a of the face page of the application form and the YES box must

be checked.  The signed, typewritten original of the application,

including the checklist, and three exact photocopies must be sent to:



Division of Research Grants

National Institutes of Health

Westwood Building, Room 240

Bethesda, MD  20892**



At the time of submission, two additional copies of the application

must be sent to:



Acting Director

Division of Scientific Review

National Institute of Child Health and Human Development

6100 Building, Room 520 5E03A

6100 Executive Boulevard

Bethesda, MD  20892



Applications must be received by February 18, 1993.  If an

application is received after that date, it will be returned to the

applicant without review.  Also, the Division of Research Grants

(DRG) will not accept any application in response to this

announcement that is essentially the same as one currently pending

initial review, unless the latter is withdrawn by the applicant.  Nor

will the DRG accept any application that is essentially the same as

one already reviewed.  This does not preclude the submission of

substantial revisions of such an application, but it must include an

introduction addressing the previous critique.



LETTER OF INTENT



Prospective applicants are asked to submit, by January 15, 1993, a

letter of intent that includes a descriptive title of the proposed

research, the name, address and telephone number of the Principal

Investigator, the identities of other key personnel and participating

institutions, and the number and title of the RFA in response to

which the application may be submitted.



Although a letter of intent is not required, is not binding, and does

not enter into the review of subsequent applications, the information

that it contains is helpful in planning for the review of

applications.  It also allows staff to estimate the potential review

workload and to avoid possible conflict of interest in the review.



The letter of intent is to be sent to Dr. Heinz W. Berendes at the

address listed under INQUIRIES.



INQUIRIES



Written and telephone inquiries concerning this RFA are encouraged,

and the opportunity to clarify any issues or questions from potential

applicants is welcome.



Inquiries regarding programmatic issues and requests for the RFA may

be directed to:



Heinz W. Berendes, M.D., M.H.S.

Director, Division of Epidemiology, Statistics, and Prevention

Research

National Institute of Child Health and Human Development

6100 Executive Boulevard, Room 7B05

Bethesda, MD  20892

Telephone:  (301) 496-5064



Inquiries regarding fiscal matters may be made to:



Mr. E. Douglas Shawver

Office of Grants and Contracts

National Institute of Child Health and Human Development

6100 Executive Boulevard, Room 8A17F

Bethesda, MD  20892

Telephone:  (301) 496-1303

FAX:  (301) 402-0915



AUTHORITY AND REGULATIONS



This program is described in the Catalog of Federal Domestic

Assistance No. 93.865, Research for Mothers and Children.  Awards

will be made under the authority of the Public Health Service Act,

Section 301 (42 USC241), and administered under PHS grants policies

and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74.  This

program is not subject to review under the intergovernmental review

requirements of Executive Order 12372 or Health Systems Agency

review.



.

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