AVAILABILITY OF HUMAN LIVER FOR SCIENTIFIC INVESTIGATION

NIH GUIDE, Volume 21, Number 42, November 20, 1992



P.T. 34



Keywords:

  Organs+ 

  Pathophysiology 



National Institute of Diabetes and Digestive and Kidney Diseases



The Liver Tissue Procurement and Distribution System (LTPADS) is a

National Institutes of Health (NIH) service contract to obtain human

liver from regional centers for distribution to scientific

investigators throughout the United States.  These regional centers

have active liver transplant programs with human subjects approval to

provide portions of the resected pathologic liver for which the

transplant is performed.  Human pathologic liver prepared according to

the investigator's specifications provides the opportunity to verify if

animal liver investigations are relevant to human liver

pathophysiology.  The preparation of these livers has been excellent

for the usual molecular biologic techniques.  Therefore, we are

primarily interested in soliciting proposals from investigators

interested in studying pathologic liver specimens.  Examples would

include a particular metabolic disorder or disease entity or the

general process of cirrhosis.  A limited supply of "normal" liver

specimens may also be requested but the turn around time for completion

of large requests for "normal" liver is much longer than for pathologic

liver specimens.



INQUIRIES



Further information and proposal forms for interested investigators can

be obtained from:



Harvey L. Sharp, M.D.

Principal Investigator, Liver Tissue Procurement and Distribution

System

c/o Elizabeth Webster

Box 179 UMHC

University of Minnesota Hospitals

Minneapolis, MD  55455

Telephone:  (612) 624-1133



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