LABORATORY FOR ASSESSMENT OF MUCOSAL IMMUNE RESPONSES INDUCED BY AIDSVACCINES IN CLINICAL TRIAL VOLUNTEERS



NIH GUIDE, Volume 21, Number 41, November 13, 1992



RFP AVAILABLE:  NIAID-DAIDS-93-18



P.T. 34



Keywords:

  AIDS 

  Vaccine 

  Bioassay 

  Immunology 



National Institute of Allergy and Infectious Diseases



The National Institute of Allergy and Infectious Diseases (NIAID), NIH,

has a requirement to provide for the centralized performance of

immunological assays to evaluate HIV-specific humoral and cellular

mucosal immune responses in support of clinical trials of prototype

AIDS vaccines.  The purpose of this contract is to support the NIAID in

its mission to stimulate research towards discovery and testing of

prototype vaccines for the acquired immunodeficiency syndrome (AIDS).

The NIAID requires a Mucosal Immunology Laboratory to evaluate

reproductive tract, gut, blood, and other mucosal specimens from

vaccine clinical trial volunteers for humoral and cellular mucosal

immune responses induced by immunization with prototype AIDS vaccines.

This effort will support the research of AIDS investigators, including

the AIDS Vaccine Evaluation Group (AVEG), the National Cooperative

Vaccine Evaluation Groups (NCVDG), and other programs initiated by

NIAID.



Specifically, the selected Contractor shall be responsible for:  (1)

performing specific immunological assays for detection of HIV-specific

antibody and cellular responses in mucosal site and blood specimens

from AIDS vaccine recipients; (2) developing standard protocols for the

collection, processing, and storage of mucosal specimens at the vaccine

trial sites; (3) receiving, cataloging, tracking, coding, storing, and

maintaining an inventory of vaccinee specimens arriving for evaluation;

and (4) maintaining a test result database and transferring data

electronically to the AIDS Vaccine Clinical Trials Network (AVCTN) Data

Coordinating and Analysis Center (DCAC).



This is an announcement for an anticipated Request for Proposals (RFP).

RFP:  NIH-NIAID-DAIDS-93-18 will be issued on or about November 13,

1992 with a closing date tentatively set for January 5, 1993.  It is

expected that one (1) contract will be awarded as a result of this

solicitation.  It is expected that the contract will have a five-year

period of performance, and a completion type cost-reimbursement

contract is anticipated.



INQUIRIES



Requests for the RFP may be directed in writing to:



Lawrence Butler, Contracting Officer

Contract Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C-07

6003 Executive Boulevard

Bethesda, MD  20892



Please provide this office with three self-addressed mailing labels.

Telephone

inquiries will not be honored and all inquiries must be in writing.  A

short-form version of the RFP will be provided first, which includes

only the statement of work and the Evaluation Criteria to be used for

selection of the awardee.



After examining this, a full-text version of the RFP must be requested

in writing by those offerors interested in responding.  FAX requests

are acceptable for the full-text version of the RFP only (FAX:

301-402-0972).  All proposals from responsible sources will be

considered by the NIAID.  This advertisement does not commit the

Government to award a contract.



.

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