Date: October 21, 2011
Open date: October 21, 2011
Response Date: November 21, 2011
After November 21, 2011, responses will no longer be considered.
This Request for Information (RFI) is issued from the Common Fund (http://commonfund.nih.gov) through the NIH Office of the NIH Director, Office of Strategic Coordination in the Division of Program Coordination, Planning, and Strategic Initiatives (http://dpcpsi.nih.gov/osc). The RFI will be administered by the National Heart Lung and Blood Institute (NHLBI/NIH), (http://www.nhlbi.nih.gov) on behalf of the NIH.
The NIH Common Fund Metabolomics Working Group is seeking comments regarding the need for high quality reference standards for use in research studies using metabolomic approaches. The NIH Common Fund supports cross-cutting programs that are expected to have exceptionally high impact. All Common Fund initiatives invite investigators to develop bold, innovative, and often risky approaches to address important problems that may seem intractable or to seize new opportunities that offer the potential for rapid progress and broad impact.
The NIH Common Fund is currently developing a multi-component program to help increase metabolomics research capacity. One of the goals of the program is to expand the repertoire of chemically identifiable metabolites through synthesis of reliable standards.
Information is requested on the following topics relating to metabolomic reference standards:
1. The classes of metabolites that most urgently require reference standards for metabolite identification and at what range of concentrations. Please include a brief rationale.
2. Whether these metabolite standards should be available in unlabeled form, labeled with radioisotopes or heavy isotopes, or available in both labeled and unlabeled forms. If labeled forms are desired, please specify the labeled element desired for each suggested metabolite.
3. The highest priority metabolite reference standard needed in your field. Please state that field.
4. The metabolite reference standards that would benefit the broadest number of biomedical fields.
5. The key quality control requirements that synthesized reference standards need to meet.
Please send responses identifying the question number above, if appropriate, to NCIMetabolomicsRFI@mail.nih.gov by November 21, 2011.
This RFI is for planning purposes only and should not be
construed as a solicitation for applications or as an obligation on the part of
the Government to provide support for any ideas identified in response to
it. Please note that the United States Government will not pay for the
preparation of any information submitted or for its use of that
Responses will be compiled and shared internally and with
working groups convened by the NIH, as appropriate. In all cases where
responses are shared, the names of the respondents will be withheld.
We look forward to your input and hope that you will share this document with your colleagues.
Please direct all inquiries to:
Pothur Srinivas, Ph.D., MPH
Division of Cardiovascular Sciences
National Heart, Lung, and Blood Institute (NHLBI)
Bethesda, MD 20892
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
Office of Extramural
National Institutes of Health (NIH)
9000 Rockville Pike
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Department of Health
and Human Services (HHS)