Small Business Innovation Research (SBIR) Program Contract Solicitation (PHS 2012-1) Now Available


Notice Number: NOT-OD-11-108

Key Dates

Release Date:  August 25, 2011
Contract Proposal Receipt Date:  November 7, 2011  

Issued by

National Institutes of Health (NIH)
Centers for Disease Control and Prevention (CDC)

Purpose

Innovative technologies and methodologies fuel progress in biomedical and behavioral research and represent an increasingly important area of the economy. The Small Business Innovation Research (SBIR) program provides support for research and development (R&D) of new or improved technologies and methodologies that have the potential to succeed as commercial products.

The purpose of this notice is to (1) announce the issuance of the Solicitation of the National Institutes of Health and the Centers for Disease Control and Prevention for Small Business Innovation Research Contract Proposals (PHS 2012-1) with a receipt date of November 7, 2011; and (2) inform the public about the opportunities that the SBIR program offers to small business concerns as well as to scientists at research institutions.

The SBIR legislation requires the Public Health Service (PHS), Department of Health and Human Services, and certain other Federal agencies to reserve 2.5 percent of their extramural research or R&D budgets for an SBIR program. (The NIH SBIR set-aside requirement for FY 2011 is $609 million.)

The offeror organization must be a small business concern as defined by the Small Business Administration and described in the Contract Solicitation. The primary employment of the principal investigator MUST be with the small business concern at the time of award and during the conduct of the proposed project. In accord with the intent of the SBIR program to increase private sector commercialization of innovations derived from Federal R&D, scientists at research institutions can play an important role in an SBIR project by serving as consultants and/or subcontractors to the small business concern. Generally, up to 1/3 of the Phase I budget may be spent on consultant and/or subcontractual costs, and, generally, up to 1/2 of the Phase II budget may be spent on such costs. In this manner, a small business concern with limited expertise and/or research facilities may benefit from teaming with a scientist(s) at a research institution; for the scientist(s) at a research institution, this team effort provides support for R&D not otherwise obtained. The SBIR program consists of the following three phases:

PHASE I: The objective of this phase is to determine the scientific and technical merit and feasibility and potential for commercialization of the proposed research or R&D efforts and the quality of performance of the small business concern, before consideration of further Federal support in Phase II. Generally, Phase I SBIR awards do not exceed $150,000 for direct costs, Facilities and Administrative (F&A) costs, and negotiated fixed fee for a period generally not to exceed six months.

PHASE II: The objective of this phase is to continue the research or R&D efforts initiated in Phase I. Funding shall be based on the results of Phase I and the scientific and technical merit and commercial potential of the Phase II proposal. Only Phase I contractors are eligible to apply for Phase II funding, and Phase II proposals may be submitted ONLY upon the request of the Contracting Officer. (However, see "Fast-Track" Initiative below.) Generally, Phase II awards do not exceed $1,000,000 for direct costs, F&A costs, and negotiated fixed fee for a period generally not to exceed two years. Only one Phase II award may be made for any SBIR project.

PHASE III: The objective of this phase is for the small business concern to pursue, with non-SBIR funds, the commercialization of the results of the research or R&D funded in Phases I and II.

"FAST-TRACK" INITIATIVE: (Applicable only to proposals submitted to the NIH and only if an awarding component indicates that it is accepting Fast-Track proposals for a particular topic.)

The Fast-Track initiative is an opportunity for small business concerns to submit both a Phase I and Phase II proposal for concurrent peer review. This initiative also has the potential to minimize any funding gap between Phase I and Phase II. Proposals must be prepared in accordance with Phase I and Phase II proposal preparation instructions.

Following are the research topics contained in the PHS 2012-1 Solicitation:

National Institutes of Health (NIH)

National Cancer Institute (NCI)

255      Development of Anticancer Agents

277      Development of Companion Diagnostics

291      Development of Radiation Modulators For Use During Radiotherapy

300      Reformulation of Cancer Therapeutics using Nanotechnology

301      Probing Tumor Microenvironment Using In Vivo Nanotechnology-based Sensors

306      Development of Innovative Algorithms for Processing & Analysis of In Vivo Images

307      Novel Imaging Agents to Expand the Clinical Toolkit for Cancer Diagnosis, Staging, and Treatment

308      Automated Collection, Storage, Analysis, and Reporting Systems for Dietary Images

309      Development of Low Cost, Small Sample Multi-Analyte Technologies for Cancer Diagnosis, Prognosis and Early Detection

310      Simplified Tissue Microarray Instrument For Clinical and Research Settings (NIH Technology Transfer)

311      High Throughput Isolation of Antigen Specific T-cells for Cancer Therapy (NIH Technology Transfer)

312      Generation and Qualification of Site-specific Post-translationally Modified Proteins for Use as Calibrators in Pharmacodynamic (PD) Assays

National Center for Research Resources (NCRR)

015      Development of an Integrated Automated High Throughput Platform for Large-Scale Genetic and Therapeutic Screening in Zebrafish

National Heart, Lung and Blood Institute (NHLBI)

044      Development of Induced Pluripotent Stem (iPS) Cell Lines for Use in Cell-based Bioassays

058      Novel Technologies for Powering Ventricular Assist Devices

063      Reagents for Studying Human Lung Cell Biology and Cellular Function

064      Novel Technologies for Assessing Lipoprotein Sub-fractions

065      Computer Generated Diet and Exercise Reminders Promoting Cardiovascular Health

066      Haptoglobin Treatment to Reduce Complications of Sickle Cell Disease

067      Transmit-receive Surface Array Coils for MRI of Patients with Internal Conductive Devices

068      Multilayer-coated Gratings for Phase-Contrast Computed Tomography

069      Wireless Physiologic Telemetry for Interventional MRI

070      Bioabsorbable Stents for Pediatric Pulmonary Artery Stenosis and Aortic Coarctation

071      Electrophysiologic Catheters for Interventional MRI Ablation of Ventricular Tachycardia

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

044      Development of Novel Compounds to Treat Alcohol Use Disorders

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

075      A Low Molecular Weight Thyroid-Stimulating Hormone Receptor Agonist for Thyroid Cancer (NIH Technology Transfer)

National Institute on Drug Abuse (NIDA)

139      Confirming Compliance with Experimental Pharmacotherapy Treatment of Drug Abuse

140      Development of a Solid Oral Dosage Form for Fenobam

141      Recovery Warrior: Behavioral Activation Video Game for Substance Abuse via a Commercially Available Active & Interactive Gaming Platform (e.g, Wii, Play Station Move, or Xbox Kinect)

142      Highly Effective Methods for Systemic In Vivo Targeted Delivery of shRNAi to the Brain for Treatment of Substance Use Disorders and Other Brain Disorders

143      Feasibility of Development of RNAi-based Therapeutics for Treatment of HIV and HCV Infections in Drug Abusing Populations

144      Smokescreen: Genetic Screening Tool for Tobacco Dependence and Treatment Approaches

145      Feedback-regulated Naloxone Delivery Device to Prevent Opiate Overdose Deaths 

146      Drugged Driving: Future Research Directions

Centers for Disease Control and Prevention (CDC)

Center for Global Health

001      The Development of Lateral Flow Immunochromatographic Devices to Detect Antibodies

002      Development of a Blood Donor Screening Test to Prevent Transfusion Transmitted Babesiosis

National Center on Birth Defects and Developmental Disabilities (NCBDDD)

015      Development of an Assay to Rapidly Determine Folate Insufficiency in the Field

National Center for Emerging Zoonotic and Infectious Diseases (NCEZID)

001      Vaccine Adverse Event Reporting System (VAERS) Application for Smartphone

002      Development of Rapid, Point-of-Care Tests for Diagnosis of Fungal Infections

National Center for HIV/AIDs, Viral Hepatitis, STD, and TB Prevention (NCHHSTP)

031      Testing the Efficacy of HIV Prevention Strategies in Nonhuman Primate Models

032      Data Mining Software for Large-Scale Analyses of Infections Caused by Hepatitis Viruses

033      Developing a Location-Based Application to Identify Adolescent-Friendly Health Care Services

Office of Public Health Preparedness and Response (OPHPR)

001      Emergency Vehicle Proximity Alert System

Inquiries

Eligibility requirements, definitions, submission procedures, review considerations, contract proposal forms and instructions, and other pertinent information, including the "Fast-Track" Initiative, are contained in the Solicitation (PHS 2012-1). The Solicitation, including contract proposal forms, is available electronically through the NIH "Small Business Research Funding Opportunities” Web site. See SBIR Phase I Contract Solicitation PHS 2012-1 (PDF [http://grants.nih.gov/grants/funding/SBIRContract/PHS2012-1.pdf] or MS Word [http://grants.nih.gov/grants/funding/SBIRContract/PHS2012-1.doc]). Be sure to use the appropriate CONTRACT PROPOSAL forms as they differ from the SF424 (R&R) GRANT application forms.

Note: The SBIR Phase I Contract Solicitation is available ONLY via electronic means. Potential offerors are encouraged to check the NIH Small Business Research Funding Opportunities Web site for updates on the program. Any updates or corrections to the Solicitation will be posted there.

Contracting Officers

Any small business concern that intends to submit an SBIR contract proposal under this Solicitation should provide the appropriate contracting officer(s) with early, written notice of its intent, giving its name, address, e-mail, telephone, and topic number(s). If a topic is modified or canceled before the Solicitation closes, only those companies that have expressed such intent will be notified.

National Institutes of Health (NIH)

National Cancer Institute (NCI)

Ms. Anita Hughes
Phone: (301) 435-3805
Fax: (301) 480-0309
Email: anita.hughes@nih.gov

National Center for Research Resources (NCRR)

Mr. John Taylor
Phone: (301) 435-0327
Fax: (301) 480-3430
E-mail: taylorjc@nhlbi.nih.gov

National Heart, Lung, and Blood Institute (NHLBI)

Mr. John Taylor
Phone: (301) 435-0327
Fax: (301) 480-3338
E-mail: taylorjc@nhlbi.nih.gov

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Mr. Matthew Packard
Phone: (301) 443-3041
Fax: (301) 443-3891
Email: packardm@mail.nih.gov

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Ms. Anita Hughes
Phone: (301) 435-3805
Fax: (301) 480-0309
E-mail: anita.hughes@nih.gov

National Institute on Drug Abuse (NIDA)

Mr. Brian O’Laughlin
Phone: (301) 443-6677
Fax: (301) 443-7595
Email: bo50d@nih.gov

Centers for Disease Control and Prevention (CDC)

For general administrative SBIR program questions, contact:

Dr. Paul Smutz
Office of Extramural Research
Office of the Associate Director for Science
Phone: (404) 639-4783
Fax (404) 639-4903
Email: wsmutz@cdc.gov

Center for Global Health (GCH)

Carlos Smiley
Contracting Officer
Phone: (770) 488-1517
Fax: (770) 488-2688
E-mail: CSmiley1@cdc.gov

National Center for Birth Defects and Developmental Disabilities (NCBDDD)

Theresa Routh-Murphy
Contracting Officer
Phone: (770) 488-2713
Fax: (770) 488-2778
Email: TNR3@cdc.gov

National Center for Emerging Zoonotic and Infectious Diseases (NCEZID)

Charlene Allison
Contracting Officer
Phone: (770) 488.2841
Fax: (770).488.4088
E-mail: CAllison@cdc.gov

National Center for HIV/AIDs, Viral Hepatitis, STD, and TB Prevention (NCHHSTP)

Julio Lopez
Contracting Officer
Phone: (770) 488-2892
Fax: (770) 488-2868
E-mail: jlopez3@cdc.gov

Office of Public Health Preparedness and Response (OPHPR)

Vivian Hubbs
Contracting Officer, Lead
Phone: (770) 488-2647
Fax: (770) 488-2670
E-mail: VHubbs@cdc.gov

Those interested in the PHS small business research GRANT programs, where investigator-initiated research ideas are encouraged, are invited to access the Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Grant Applications (PHS 2011-2). There is one grant application due date (December 5, 2011) remaining for calendar year 2011.

To understand better the differences between grants and contracts, see Contracts vs. Grants: What's the difference?


Weekly TOC for this Announcement
NIH Funding Opportunities and Notices


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