SMALL BUSINESS INNOVATION RESEARCH PROGRAM
 
RELEASE DATE:  August 3, 2004
 
NOTICE:  NOT-OD-04-055
 
National Institutes of Health (NIH)
Centers for Disease Control and Prevention (CDC)
 
Contract Proposal Receipt Date:  November 5, 2004
 
Innovative technologies and methodologies fuel progress in biomedical 
and behavioral research and represent an increasingly important area of 
the economy.  The Small Business Innovation Research (SBIR) program 
provides support for research and development (R&D) of new or improved 
technologies and methodologies that have the potential to succeed as 
commercial products. 
 
The purpose of this notice is to (1) announce the issuance of the 
SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATION 
RESEARCH CONTRACT PROPOSALS (PHS 2005-1) with a due date of NOVEMBER 5, 
2004 for receipt of SBIR CONTRACT proposals; and (2) inform the public 
about the opportunities that the SBIR program offers to small business 
concerns as well as to scientists at research institutions.  The SBIR 
legislation requires the Public Health Service (PHS), Department of 
Health and Human Services, and certain other federal agencies to 
reserve 2.5 percent of their extramural research or R&D budgets for an 
SBIR program.  The PHS SBIR set-aside requirement for FY 2004 is $563 
million.
 
The offeror organization must be a small business concern as defined by 
the Small Business Administration and described in the Solicitation, 
and the PRIMARY EMPLOYMENT of the principal investigator MUST be with 
the small business concern at the time of award and during the conduct 
of the proposed project. In accord with the intent of the SBIR program 
to increase private sector commercialization of innovations derived 
from federal R&D, scientists at research institutions can play an 
important role in an SBIR project by serving as consultants and/or 
subcontractors to the small business concern.  Generally, one-third of 
the Phase I budget may be spent on consultant and/or subcontractual 
costs, and, generally, one-half of the Phase II budget may be spent on 
such costs. In this manner, a small business concern with limited 
expertise and/or research facilities may benefit from teaming with a 
Scientist(s)at a research institution; for the scientist(s)at a 
research institution, this team effort provides support for R&D not 
otherwise obtained.
 
The SBIR program consists of the following three phases:
 
PHASE I: The objective of this phase is to determine the scientific and 
technical merit and feasibility and potential for commercialization of 
the proposed research or R&D efforts and the quality of performance of 
the small business concern, before consideration of further federal 
support in Phase II. Generally, Phase I SBIR awards do not exceed 
$100,000 for direct costs, Facilities and Administrative (F&A) costs, 
and negotiated fixed fee for a period generally not to exceed six 
months.
 
PHASE II: The objective of this phase is to continue the research or 
R&D efforts initiated in Phase I. Funding shall be based on the results 
of Phase I and the scientific and technical merit and commercial 
potential of the Phase II proposal. Only Phase I contractors are 
eligible to apply for Phase II funding, and Phase II proposals may be 
submitted upon the request of the Contracting Officer ONLY.  (However, 
see "Fast-Track" Initiative below.) Generally, Phase II awards do not 
exceed $750,000 for direct costs, F&A costs, and negotiated fixed fee 
for a period generally not to exceed two years.  That is, generally, a 
two-year Phase II project does not cost more than $750,000 for that 
project.  Only one Phase II award may be made for any SBIR project.
 
PHASE III: The objective of this phase is for the small business 
concern to pursue, with non-SBIR funds, the commercialization of the 
results of the research or R&D funded in Phases I and II.
 
"FAST-TRACK" INITIATIVE: (Applicable only to proposals submitted to the 
National Institutes of Health [NIH] and only if an awarding component 
indicates it is accepting Fast Track proposals for a particular topic.)
 
The Fast-Track initiative is an opportunity for small business concerns 
to submit both a Phase I and Phase II proposal for concurrent peer 
review. This initiative also has the potential to minimize any funding 
gap between Phase I and Phase II. Proposals must be prepared in 
accordance with Phase I and Phase II proposal preparation instructions.
 
Following are the research topics contained in the SOLICITATION OF THE 
PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH CONTRACT 
PROPOSALS (PHS 2005-1) for the contract proposal RECEIPT DATE of 
NOVEMBER 5, 2004:
 
NATIONAL INSTITUTES OF HEALTH   
 
National Institute on Alcohol Abuse and Alcoholism (NIAAA)   
 
o 017   Development of Methodology for Measuring Compliance for 
Medications 
 
o 026   Science Education Materials Development for Kindergarten 
through 12th Grade
 
o 027   Development and Clinical Testing of Biochemical Markers
 
National Cancer Institute (NCI)   
 
o 195   Virtual Microscopy for the Early Detection of Cancer   
 
o 196   Antibody Array for Cancer Detection   
 
o 197   Early Detection Research Network Bioinformatics Research 
Program (EDRN-BRP)   
 
o 198   Chemical Optimization and Structure-Activity Relationships   
 
o 203   Development of a Database and Candidate Gene, Protein, and 
Biochemical Pathway Nomination Software for Tobacco-Related Disease and 
Tobacco Addiction Investigations
 
o 204   Plant Genomic Models for Establishing Physiological Relevance 
of Bioactive Components as Cancer Protectants
 
o 205   Metabolomics for Early Cancer Detection
 
o 206   Methods for Innovative Pharmaceutical Manufacturing and Quality 
Assurance
 
o 207   Synthesis Modules for Radiopharmaceutical Production
 
o 208   Targetry Systems for Production of Research Radionuclides
 
o 209   Establishment of Benchmark Data Sets for Radiotherapy Quality 
Assurance
 
o 210   Using Social Marketing to Disseminate Evidence-based Energy 
Balance Intervention Approaches to Worksites
 
o 211   Developing Item Response Theory Software for Outcomes and 
Behavioral Measurement
 
o 212   Integrating Patient-Reported Outcomes in Clinical Oncology 
Practice
 
o 213   Portable e-Technology Tools For Real-Time Energy Balance 
Research
 
o 214   Systems to Enhance Data Collection and Medication Compliance in 
Clinical Trials
 
National Institute on Drug Abuse (NIDA)   
 
o 028   Prevention Training
 
o 029   Development of Science Education Materials or Programs
 
o 060   Develop New Technologies for Screening and Assessing Drug Abuse 
and Matching Patients with Appropriate Treatment Services
 
o 065   Development of New Chemical Probes and Discovery of Alternate 
Drug Delivery Dosage Forms for Drug Abuse Studies 
 
o 067   Development of Novel Approaches in Human Neuroscience   
 
o 070   Develop Research Training Modules for International Application
 
o 071   Microarray Technology Applications in Drug Abuse and Addiction
 
o 072   Medicinal Chemistry - Design and Synthesis of Novel Chemical 
Libraries for Treatment Agents for Drug Abuse
 
o 073   Internet-based Application of Existing/Proven Therapies
 
o 074   Development of Cell-Based Assays to Identify Therapeutic 
Targets for Substance Abuse and Addiction
 
o 075   Real-time Data Collection Paired with Ecological Momentary 
Assessment (EMA)
 
National Institute of Mental Health (NIMH)   
 
o 045   Suicide Prevention Materials and Training for Criminal and 
Civil Court Systems (Adult/Geriatric/Child and Adolescent Populations)  
 
o 055   Development of Tools to Enhance Mental Health Interventions and 
Services Research Training: Executive Research Leadership or 
Science/Research Education Curriculum
 
National Heart, Lung, and Blood Institute (NHLBI)   
 
o 031   New Technology Development for Global Assay of Blood 
Coagulation
 
o 032   Bioreactor Production of Clinical Grade rAAV in Sf9 Cells for 
DMD
 
CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC)   
 
National Center for HIV, STD AND TB Prevention (NCHSTP)   
 
o 021   Development of a Novel Internet-Based Information System for 
Remote TB Control and Prevention Programs
 
National Center for Environmental Health (NCEH)   
 
o 014   Unmanned Aerial Vehicle and Imagery for Humanitarian Response
 
o 015   Automated User Defined Tool for Emergency Planning and Quality 
Control
 
National Immunization Program (NIP)   
 
o 016   Develop Methods to Enhance Administration of Vaccines, 
Including Live Virus Vaccines, Through the Respiratory Tract   
 
o 019   Disposable-Cartridge Jet Injector Technology
 
National Center for Infectious Diseases (NCID)  
 
o 033   Development of Serologic Assays to Measure Immune Responses in 
Anthrax
 
o 034   Biological Control of Lyme Disease Spirochete Vector Ticks
 
o 035   Oral Vaccines that Target Peridomiciliary Lyme Disease 
Reservoirs
 
o 036   Murine Monoclonal Antibody/Human IgM Chimeric Antibody 
Construction and Expression
 
o 037   Vaccination of Birds for West Nile Virus Using Recombinant 
Seeds
 
o 038   Development of Novel Reagents for Poxvirus Research and 
Diagnostics
 
o 039   North American Orthopoxviruses as Vaccine Vectors: Safety, 
Efficacy and Feasibility
 
o 040   Assay Development for Taenia solium Cysticercosis and Taeniasis
 
National Center on Birth Defects and Developmental Disabilities NCBDDD)   
 
o 001   Development of Materials for "Birth Defects Prevention Month"
 
o 002   Development of Health Communication Materials to Prevent 
Alcohol-Exposed Pregnancies in Underserved Populations
 
o 003   Development, Production, and Evaluation of a Folic Acid 
Educational Tool for Use with a Variety of Audiences
 
o 004   Teratogen Symbol Testing among Diverse Audiences
 
o 005   Development of Health Education Materials to Promote 
Pre-Pregnancy Health Visits
 
INQUIRIES
 
Eligibility requirements, definitions, submission procedures, review 
considerations, contract proposal forms and instructions, and other 
pertinent information, including the "Fast-Track" Initiative, are 
contained in the SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL 
BUSINESS INNOVATION RESEARCH CONTRACT PROPOSALS (PHS 2005-1) for the 
proposal receipt date of November 5, 2004. The PHS SBIR Contract 
Solicitation PHS 2005-1, including proposal forms, is available 
electronically through the National Institutes of Health's "Small 
Business Funding Opportunities" home page at 
http://grants.nih.gov/grants/funding/sbir.htm. See SBIR Phase I 
Contract Solicitation PHS 2005-1 (PDF 
[http://grants.nih.gov/grants/funding/SBIRContract2005/PHS2005-1.pdf] 
or MS Word 
[http://grants.nih.gov/grants/funding/SBIRContract2005/PHS2005-1.doc]). 
Be sure to use the appropriate CONTRACT PROPOSAL forms as they differ 
from the PHS 398 GRANT application forms.
 
Note: The SBIR Phase I Contract Solicitation will only be available via 
electronic means. Potential offerors are encouraged to check the NIH 
SBIR/STTR home page for updates on the program. Any updates or 
corrections to the solicitation will be posted there.
 
Contracting Officers 
 
Any small business concern that intends to submit an SBIR contract 
proposal under this Solicitation should provide the appropriate 
contracting officer(s) with early, written notice of its intent, giving 
its name, address, telephone, and topic number(s).  If a topic is 
modified or canceled before this Solicitation closes, only those 
companies that have expressed such intent will be notified.
 
NATIONAL INSTITUTES OF HEALTH (NIH)
 
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Ms. Roberta Wilhelm
Phone: (301) 443-1191
Fax: (301) 443-3891
Email: rwilhelm@niaaa.nih.gov 
 
National Cancer Institute (NCI)
Mr. Joseph Bowe
Phone: (301) 435-3810
Fax: (301) 480-0309
Email: jb166i@nih.gov 
 
National Institute on Drug Abuse (NIDA)
Ms. Nancy A. Hurd
Phone: (301) 443-6677
Fax: (301) 443-7595
Email: nhurd@nida.nih.gov
 
National Institute of Mental Health (NIMH)
Mr. David Eskenazi
Phone: (301) 443-2696
Fax: (301) 443-0501
Email: de5d@nih.gov
 
National Heart, Lung, and Blood Institute (NHLBI)
Mr. Robert Best
Phone: (301) 435-0330
Fax: (301) 480-3338
Email: bestr@nhlbi.nih.gov
 
CENTERS FOR DISEASE CONTROL AND PREVENTION
 
National Center for HIV, STD, and TB Prevention (NCHSTP)
National Center for Environmental Health (NCEH)
National Immunization Program (NIP)
National Center for Infectious Diseases (NCID)
National Center on Birth Defects and Developmental Disabilities NCBDDD)
 
Mr. Curt Bryant 
Phone: (770) 488-2806
Fax: (770) 488-2828
Email: ckb9@cdc.gov 
 
Those interested in the PHS SBIR/STTR GRANT program may access 
electronically (http://grants.nih.gov/grants/funding/sbir.htm) the 
OMNIBUS SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS 
INNOVATION RESEARCH (SBIR) and SMALL BUSINESS TECHNOLOGY TRANSFER 
(STTR) GRANT APPLICATIONS (PHS 2004-2). There is one GRANT APPLICATION 
receipt date (December 1, 2004) remaining for calendar year 2004. 
 
To better understand the differences between grants and contracts, see 
http://grants.nih.gov/grants/funding/contracts_vs_grants.htm.


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