NINDS ADMINISTRATIVE SUPPLEMENTS FOR COLLABORATIVE RESEARCH ON BRAIN TRAUMA RELEASE DATE: June 17, 2003 NOTICE: NOT-NS-03-019 National Institute of Neurological Disorders and Stroke (NINDS) (http://www.ninds.nih.gov) The National Institute of Neurological Disorders and Stroke (NINDS) announces an administrative supplement program to facilitate collaborative research on the mechanisms of damage and recovery after traumatic brain injury (TBI). The program is intended to facilitate collaboration between investigators with ongoing, peer-reviewed projects that address TBI with investigators with primary research interests in neurodevelopmental or neurodegenerative disorders, ischemic brain injury, brain damage after global ischemia, trauma to the spinal cord, or brain injury that results from exposure to environmental toxins or drugs of abuse. The supplements are intended to support the exchange of information, animal models, personnel, training, or reagents among laboratories. A total of $500,000 in Fiscal Year 2004 will be made available for this program. TBI involves many cellular mechanisms and time windows for damage and recovery, and several animal models have been developed that address treatment in the acute phases of injury. Data are beginning to accumulate from various projects on brain disorders indicating that common mechanisms of damage or approaches to treatment exist. In addition, expression of genes and/or proteins that change during development or aging may be mimicked in models of neurodegenerative disorders or after ischemic or traumatic injury. Long-term consequences of alterations in expression or posttranslational modification may affect the functional anatomy of the brain in many injury paradigms. New strategies for intervention may emerge if we encourage collaborations among researchers across disciplines of induced injury, degeneration, and developmental disorders. Evidence should be presented that the results of the supplemental assistance will significantly enhance the pursuit of Specific Aims of the participating research project in TBI and bring new approaches to the problems addressed by the research. Descriptions should be concise, but sufficiently detailed to make clear the collaborative research plan and the relationship of the results of the proposed experiments to the goals of the original project. ELIGIBILITY Principal Investigators (PIs) with Research Project (R01), Program Project (P01), and Research Center (P50) grants funded by NINDS are eligible to apply. To be eligible, projects must be funded in Fiscal Year 2004 and have at least one additional year of funding remaining. At least one of the laboratories participating in each collaboration must have a primary research interest in traumatic injury to the adult brain. HOW TO APPLY An original and five copies of the supplement application should be sent by mail or courier to the NINDS program staff contact listed at the end of this notice. The application packet should include: 1) A cover page citing this NOTICE (line 2) and requesting an administrative supplement for collaborative research. The PI and the institutional official must sign the cover page. For P01s and P50s, the PI of the program project or center must submit the request for a supplement; however, the investigator(s) participating in the supplement research project should be named and submit biographical information. 2) A concise (5-8 pages) description of the proposed project, including an Abstract, a Description of the proposed experiments and their relationship to the goals of the original project, a discussion of the Significance of the results, and Plans for sharing data. 3) Letter(s) of support and agreement from all collaborators. 4) Biographical Sketches of the PIs participating in the collaboration. 5) Specific Aims from the original grant. 6) A modular Budget with justifications. POST-AWARD REQUIREMENTS A one-page report that specifically addresses the results of the supplement will be required. It should be included as an addition to the next progress report of the parent grant, submitted the year following the supplement award. BUDGET INFORMATION A total of $500,000 in Fiscal Year 2004 will be made available for this program. For each request, the maximum direct cost is $50,000 in modular amounts of $10,000. Please note that Facilities and Administrative (F&A) costs for subcontracts are to be included in the direct costs. Although the awarded budgets will be modular, applicants should provide a budget justification that details the budget items requested, including F&A. REVIEW PROCEDURE Applications will be reviewed administratively, and it is expected that for successful applications a resulting Supplemental Notice of Grant Award will be issued within three months of the receipt deadline. All funding decisions are final and are not subject to appeal. Review criteria will include the relevance of the proposed activity to collaborative approaches to research in traumatic brain injury. RECEIPT DATE: October 15, 2003 ANTICIPATED AWARD DATE: January 2004 INQUIRIES Direct inquiries regarding programmatic issues to: Mary Ellen Michel, Ph.D. NINDS/NIH 6001 Executive Boulevard, NSC-2222 Bethesda MD 20892-9525 Rockville, MD 20852 (courier) Tel: 301-496-1447 Fax: 301-480-1080 Email: mm108w@nih.gov Direct inquiries regarding fiscal matters to: Rita Sisco Grants Management Branch National Institute of Neurological Disorders and Stroke 6001 Executive Blvd., NSC-3249 Bethesda, Maryland 20892 Tel: 301-496-9231 Fax: 301-402-0219 Email: rr46w@nih.gov
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