HUMAN GENETIC RESOURCE CENTER: DNA AND CELL LINE REPOSITORY

Release Date: March 6, 2002

NOTICE: NOT-NS-02-012

RFP Available: NIH-NINDS-RFP-02-03 

National Institute of Neurological Disorders and Stroke (NINDS)
 (http://www.ninds.nih.gov)

The National Institute of Neurological Disorders and Stroke (NINDS) has the 
stated mission to reduce the burden of neurological disease—a burden borne by 
every age group, by every segment of society, by people all over the world.   
Within this mission falls gene discovery. Gene discovery elucidates the cause of 
some diseases, and also, the underlying pathogenesis of related disorders. 
Genetic studies of neurological disorders are increasing in number and 
complexity.  Such studies require a large and diverse sample and accompanying 
information base. Thus, a repository of DNA samples, immortalized cell lines 
(from which DNA can be extracted continuously), and accompanying clinical and 
pedigree data is clearly an invaluable resource for the neuroscience community. 
This project is conceptually related to repositories in existence at other 
institutes at the NIH.  To date, no such resource has been available to the 
investigators studying the genetics of Neurological diseases. An NINDS 
repository will allow receipt, storage, maintenance, standardization, quality 
control, and equitable, ethical distribution of DNA and other resources 
important to research in Neurological diseases.  This will allow sharing of 
resources, as mandated by NIH policy, and thus will encourage work by junior 
investigators, investigators with novel approaches, and others not included 
in current collaborations, without excluding those who are established in their 
fields.  It will ensure that research participants will be making a maximal 
contribution, and decrease duplicative sampling efforts.  Personnel with 
established expertise in DNA preparation, lymphoblast immortalization/cell line 
preparation, data management, power analysis/statistical support for genetic 
studies, biological materials receipt/distribution, and subject identify 
protection, will be needed to perform this research.  

It is anticipated that one award may be made for a period of five years in 
September 2002.  

Request for Proposals (RFP) NIH-NINDS-02-03 will ONLY be AVAILABLE 
ELECTRONICALLY at either one of the following websites: 
http://www.FedBizOpps.gov/ or http://www.ninds.nih.gov/funding/currentrfps.htm, 
15 or more calendar days after the issuance of this synopsis.  OFFERORS ARE 
RESPONSIBLE FOR ROUTINELY CHECKING EITHER WEBSITE FOR ANY POSSIBLE SOLICITATION 
AMENDMENTS THAT MAY BE ISSUED.  NO INDIVIDUAL NOTIFICATION OF ANY AMENDMENTS 
WILL BE PROVIDED.  All responsible sources may submit a proposal which shall be 
considered by the agency.  Refer to numbered note 26.****

INQUIRIES

Inquiries may be directed to:

Patricia S. Denney, Contracting Officer
Contracts Management Branch
National Institute of Neurological Disorders and Stroke
Neuroscience Center, Room 3287
6001 Executive Boulevard, MSC 9531
Bethesda, MD  20892-9531
Tel:  (301) 496-1813
Fax:  (301) 402-4225
Email:  PD22N@NIH.GOV


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