NIDDK ADMINISTRATIVE SUPPLEMENTS FOR HUMAN EMBRYONIC CELL LINE RESEARCH

Release Date:  January 29, 2002

NOTICE:  NOT-DK-02-003

Update: July 7, 2009 – This Notice is superseded by NIH-OD-09-116 NIH Guidelines
for Human Stem Cell Research

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (http://www.niddk.nih.gov/) The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces the availability of administrative supplements to NIDDK grantees to conduct research using human embryonic stem (ES) cell lines. The cell line used must be listed on the NIH Registry of human ES cell lines (http://escr.nih.gov/). NIDDK-funded investigators may request an administrative supplement for the purpose of conducting research for any period, up to the duration of the currently funded project. The parent grant must have at least a one year of funding period remaining at the time of the supplement award. Although there is no formal budget cap for these requests, potential applicants are strongly encouraged to contact NIDDK staff to discuss budgets at an early stage of the application process. The work proposed must be within the scope of the research recommended by peer review. For example, investigators carrying out animal or adult human ES cell work may elect to request funding to extend their investigations to human ES cell lines. Investigators with current NIDDK grant support in related areas may also apply. However, in all cases careful explanation and justification must be included to document that the proposed work is within the scope of an existing, funded application. Investigators must independently contact the human ES cell line providers listed on the NIH Registry and make arrangements including any required material transfer agreements (MTA) so the human ES cell line can be obtained. Applicants must indicated which human ES cell line or lines will be used and include a letter stating that the provider will supply the human ES cell line. The investigators should also demonstrate either prior ability to work with human ES cell lines or an outline of plans for obtaining expertise to culture human ES cells. The human ES cell line providers, other laboratories with ES cell experience, or laboratory training courses on ES cell methods are potential means of obtaining this training. Other means for acquiring human ES cell expertise may be proposed. All requests for these administrative supplement awards in Fiscal Year 2002 must be received by the NIDDK by July 1, 2002. Awards will be made depending on the receipt of a sufficient number of qualified applications and the availability of funds. To apply for an administrative supplement, send an original letter and one copy countersigned by the grantee institution"s authorized business official to Dr, Badman, Karp or Sato at the addresses below. The letter (5 page limit) must include: 1) an abstract of the proposed supplemental activity and how it is related to the parent grant, 2) expected overall impact of the requested supplement on ongoing research results, 3) the NIH code for the human ES cell line(s)and a letter indicating the provider(s) will supply the cell line(s) 4) a justification of budget request and funding period and 5) current contact information for the principal investigator, including mailing and e-mail address. Although these descriptions should be as concise as possible, sufficient detail must be provided to allow the NIDDK to determine if the request qualifies as an administrative supplement. NIDDK will consider supplement requests from all eligible applicants. Requests will be evaluated according to the following criteria: o The proposed research falls within the scope of the parent grant and is a logical extension of the goals and objectives, but not sufficiently different to constitute new research or program expansion. o Evidence of prior ability to work with human ES cell lines or an outline of plans for obtaining expertise to culture human ES cells. o Documentation and justification of the requested budget. Supplement requests will be reviewed by a committee of NIDDK program staff. Award decisions will be based upon the criteria provided above, availability of funds, and NIDDK programmatic priorities and balance. Direct inquiries regarding program issues to: Dr. David G. Badman Division of Kidney, Urologic, and Hematologic Diseases National Institute of Diabetes and Digestive and Kidney Diseases 6707 Democracy Blvd., Rm. 621, MSC 5458 5458, Bethesda, MD 20892-5458 (For FedEx and UPS, use Bethesda, MD 20817) Phone: (301) 594-7717 Fax: 301-480-3510 Email: db70f@nih.gov Dr. Robert W. Karp Division of Digestive Diseases and Nutrition National Institute of Diabetes and Digestive and Kidney Diseases 6707 Democracy Boulevard, Room 671, Bethesda, MD 20892-5450 (For FedEx and UPS, use Bethesda, MD 20817) 301-451-8875 Fax: 301-480-8300 Email: karpr@extra.niddk.nih.gov Dr. Sheryl Sato Division of Diabetes, Endocrinology, and Metabolic Diseases National Institute of Diabetes and Digestive and Kidney Diseases/NIH 6707 Democracy Plaza, Room 6105 Bethesda, MD 20892-5460 (For FedEx and UPS, use Bethesda, MD 20817) Phone: (301) 594-8811 Fax: (301) 480-3503 Email: satos@extra.nddk.nih.gov Direct inquiries regarding fiscal issues to: Teresa Farris Marquette Senior Grants Management Specialist NIDDK/DEA/GMB Two Democracy Plaza, Room 728 6707 Democracy Blvd. Bethesda, MD 20892-5452 (For Courier service, use Zip Code 20817) 301-594-7682 301-480-3504 (fax) FarrisT@extra.niddk.nih.gov


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