ADMINISTRATIVE SUPPLEMENTS FOR GENE PROFILING METHODS Release Date: December 13, 1999 NOTICE: DK-00-001 National Institute of Diabetes and Digestive and Kidney Diseases The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces the availability of administrative supplements to NIDDK grantees to facilitate the development and application of microarray or other gene profiling technologies. The NIDDK ultimately wishes to facilitate wide dissemination of these methods and associated resources to NIDDK grantees. An RFA for gene expression resources to support projects in areas within the NIDDK’s mission (DK-00-002) has been issued (NIH Guide, September 23, 1999) and is available at http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-00-002.html. This administrative supplement program is designed to provide a temporary mechanism to enable NIDDK investigators to use comprehensive gene profiling methods. Investigators currently supported by the following grant mechanisms funded by NIDDK are eligible to apply: research project (R01), MERIT award (R37), program project (P01), special centers of excellence (P50), and research project cooperative agreement (U01). The work proposed must be within the scope of the research originally recommended by peer-review. Applicants can request one year of support for no more than $35,000 in direct costs. Projects must have one year or more remaining at the time of the anticipated supplement (September 30, 1999). Each investigator may only submit one application. There is no restriction on the type of gene profiling technology that the applicant may select. Examples of research areas appropriate to this announcement include, but are not limited to (1) determination of global gene expression patterns and monitoring of changes under normal and experimental/pathological conditions, (2) identification of novel expressed sequence tags (ESTs) involved in normal function and pathogenesis of disease, (3) development of efficient experimental protocols for using cDNA arrays to study gene expression patterns in human or animal tissues, including methods to prepare hybridization probes from small pathology specimens, micro-dissected tissues, or single cells, (4) enhancement of currently available gene profiling analysis tools, including data tracking, image analysis, and bioinformatics tools, (5) development of higher-order analysis tools and software algorithms to process gene expression data to predict gene-gene interactions and functional pathways. NIDDK has set aside up to $1 million in FY 2000 for this one-time announcement. Requests must be received by March 15, 2000. To apply for a supplement, send an original letter and 2 copies countersigned by the grantee institution’s business officer to Dr. Robert A. Star at the address below. The letter (5 page limit) must include: 1) an abstract of the proposed supplemental activity, 2) a detailed description of the proposed activity, including methodology and resources available, 3) impact of the requested supplement on ongoing research, 4) expected outcome, 5) a budget of no more than $35,000 in direct costs for the one year, carefully justifying methodologies, technologies, bioinformatics, statistical analytical tools, data-sharing arrangements, and costs, 6) any pre-existing intellectual property rights, including options to for-profit research sponsors, associated with the clones, sequences, and experimental results that may be generated, and 7) current PI e-mail address. Although these descriptions should be as concise as possible, sufficient detail must be provided to allow the NIDDK to judge the merit of the requested supplement. The current aims of the parent grant should be submitted as a separate attachment (not included in the 5-page limit). NIDDK will consider supplement requests from all eligible applicants. However, because funds are limited, highest priority will be given to supplement requests that meet the following criteria: o The proposed experiments are within the scope of the funded project and will significantly improve its progress. o The applicant has the resources and expertise necessary to perform the experiments and agrees to release data in a timely manner. o The applicant’s plans for quality control and bioinformatics support are adequate. o The applicant has carefully documented and justified the requested budget. Grantees are encouraged to discuss the request with their NIDDK program director or the individuals listed below before applying. In addition, please send an e-mail to GeneProfile@extra.niddk.nih.gov indicating the correct e-mail and mailing address of the applicant. Please place SUBMISSION OF ADMINISTRATIVE SUPPLEMENTS FOR GENE PROFILING METHODS in the subject field. Acknowledgement of receipt of the supplement letter will be provided by email. The request will be evaluated and prioritized by an NIDDK committee of extramural scientific staff with expertise in the scientific area. No written critique will be provided. Award decisions will be based upon 000000scientific merit, availability of funds, and programmatic priorities, including program relevance of the hypothesis-driven scientific project that will be aided by the advanced technology. Funds will be awarded by September 30, 2000. Answers to Frequently Asked Questions (FAQ) will be available at http://www.niddk.nih.gov under FAQ. Direct inquiries regarding programmatic issues to: Robert A. Star, M.D. Division of Kidney, Urologic, and Hematologic Diseases National Institute of Diabetes and Digestive and Kidney Diseases 45 Center Drive MSC 6600 Bethesda, MD 20892-6600 Phone: (301) 594-7715 FAX: (301) 480-3510 E-mail: StarR@extra.niddk.nih.gov Philip F. Smith, Ph.D. Division of Diabetes, Endocrinology, and Metabolic Diseases National Institute of Diabetes and Digestive and Kidney Diseases 45 Center Drive MSC 6600 Bethesda MD 20892-6600 Phone: (301) 594-8816 FAX: (301) 480-3503 E-mail: ps56z@nih.gov Jose Serrano, M.D., Ph.D. Division of Digestive Diseases and Nutrition National Institute of Diabetes and Digestive and Kidney Diseases 45 Center Drive MSC 6600 Bethesda MD 20892-6600 Phone: (301) 594-8871 FAX: (301) 480-8300 E-mail: SerranoJ@extra.niddk.nih.gov

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