REQUEST PROPOSALS FOR ACCESS TO A WHOLE GENOME ASSOCIATION SCANNING RESOURCE TO IDENTIFY DRUG ADDICTION LOCI RELEASE DATE: March 25, 2004 NOTICE: NOT-DA-04-006 (see NOT-DA-04-007) National Institute on Drug Abuse (NIDA) (http://www.nida.nih.gov) PURPOSE The purpose of this announcement is to solicit applications from qualified investigators to use a NIDA-supported resource to conduct a genome wide association study for drug addiction vulnerability loci. NIDA anticipates contracting a resource to conduct whole genome SNP association scanning by September 2004. This resource will use 1.5 million SNP markers evenly distributed throughout the genome as surrogates to identify differences in genomic sequences of pooled individuals. The 1.5 million whole genome association study will identify the underlying genetic components involved in addiction by identifying those SNPs that have a significantly different frequency in drug addicted compared with the non-drug addicted individuals. Once individual SNPs are identified as being associated with addiction, a second screen of those particular SNPs will be performed by the resource on the individual DNA samples from the pools. Once confirmed, a completely different set of DNA samples (addicted and non-addicted) will be used by the resource to replicate the findings and validate the association of the SNPs to addiction. The successful applicant or group of collaborative investigators working together will be provided with a set of significantly associated SNPs following submission and analysis of DNA samples. Applications from a consortium of investigators working together are highly encouraged to maximize the usefulness of the resource and to obtain an appropriate sample set and sample size for the study. NIDA requests that qualified applicants submit proposals by July 1, 2004 describing an appropriate study design for accessing this whole genome SNP association scanning resource. Highly dense genome-SNP association scanning is a powerful method to detect association of genetic loci with a complex phenotype such as addiction. Success of this project relies on two key factors: (1) a high-density SNP array to perform linkage disequilibrium analyses, and (2) a large number of well-characterized DNA samples and their associated phenotypic definitions from drug addicted and non-drug addicted individuals. To qualify for this solicitation, applicants must be or previously have been NIDA Genetics Consortium (NGC) members, or become members of the NGC on or before July 1, 2004. To learn more about becoming a member of the NGC, please refer to: http://www.drugabuse.gov/about/organization/genetics/FAQ_GeneticStudies.html For more information concerning this initiative including application procedures and review criteria refer to: http://www.drugabuse.gov/about/organization/genetics/SNP.html INQUIRIES Inquiries concerning this notice are strongly encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct programmatic inquiries to: Joni Rutter, Ph.D. Genetics and Molecular Neurobiology Research Branch Division of Neuroscience and Behavioral National Institute on Drug Abuse 6001 Executive Boulevard, Room 4S-4282, MSC 9555 Bethesda, MD 20892-9555 Telephone: (301) 443-6300 Email: jrutter@mail.nih.gov
Return to NIH Guide Main Index
Office of Extramural Research (OER) |
National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892 |
Department of Health and Human Services (HHS) |
||||||||
Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files. |