STRUCTURAL BIOLOGY OF MEMBRANE PROTEINS (PA-99-004) - ADDENDUM

Release Date:  October 12, 2000

NOTICE:  DA-01-004

National Institute on Drug Abuse

This notice is an addendum to program announcement PA-99-004, which was 
released in the NIH Guide for Grants and Contracts on October 16, 1998.  
This PA supports work leading to atomic level resolution of membrane 
proteins.  This addendum adds the National Institute on Drug Abuse 
(NIDA) as a participant in this program announcement.

The NIDA is interested in furthering the understanding of the structure 
of various membrane receptors and transporters, including the 
following:  cannabinoid CB1 and CB2, orphanin (ORL1), vanilloid (VR1), 
opioid mu, delta, and kappa, GABAa, neuronal nicotinic acetylcholine 
subtypes (nAChRs), dopamine, serotonin,  and norepinephrine 
transporters, dopamine and serotonin subtype receptors, N-methyl-D-
aspartate (NMDA) subtypes, group II metabotropic glutamate (mGluR) 
subtypes, and tachykinin (NK) subtypes.    

Using the mechanisms available under PA-99-004, applicants are 
encouraged to pursue techniques designed to express, solubilize, 
purify, and stabilize these receptors and transporters, and to obtain 
single particles, two dimensional, or even three dimensional crystals 
for electron microscopy and cryo-microscopy, and diffraction studies.

The following are NIDA contacts:

Direct inquiries regarding programmatic issues to:

Paul Hillery, Ph.D.
Rao Rapaka, Ph.D.
Division of Neuroscience and Behavioral Research
National Institute on Drug Abuse
6001 Executive Boulevard   Room 4282, MSC 9555
Bethesda, MD  20892-9555
Telephone: (301)-443-6275
Fax:  301-594-6043
E-mail:  ph44x@nih.gov

Direct inquiries regarding fiscal matters to:

Gary Fleming, J. D., M. A.
Grants Management Branch
National Institute on Drug Abuse
6001 Executive Boulevard. Room 3158, MSC 9541
Bethesda, MD  20892-9541
Telephone:  (301)-443-6710
E-mail:  gf6s@nih.gov

Direct inquiries regarding review matters to:

Teresa Levitin, Ph.D.
Office of Extramural Affairs
National Institute on Drug Abuse
6001 Executive Boulevard, Room 3158, MSC 9547
Bethesda, MD   20892-9547
Telephone:  (301)-443-2755
Fax:  (301)-443-0538
E-mail:  t125u@nih.gov

Return to Volume Index

Return to NIH Guide Main Index

	Office of Extramural Research (OER)			National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892			Department of Health and Human Services (HHS)
Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.