Notice of Availability of Administrative Supplements to NCI Cancer Health Disparities Awards for Behavioral Strategies to Accrue and Retain Diverse Underserved Populations in HIV-Related Malignancy Clinical Trials


Notice Number:  NOT-CA-11-018

Key Dates

Release Date: June 28, 2011
Receipt Date: July 22, 2011
Earliest Anticipated Start Date: September 15, 2011

Issued by

National Institutes of Health (NIH)
National Cancer Institute (NCI)

Purpose

The Center to Reduce Cancer Health Disparities (CRCHD) of the National Cancer Institute (NCI) announces an administrative supplement program to build or expand collaborations focused on cancer among HIV-infected persons from diverse racial/ethnic populations or the underserved (e.g., rural, poor, uninsured) populations. The collaborations proposed are expected to comprise AIDS Malignancy Consortium (AMC) researchers, cancer health disparities (CHD) researchers, and community organizations. Upon conclusion of the supplement program, collaborations will: 1) implement a successful intervention for accruing and retaining patients from diverse backgrounds to HIV-related malignancy clinical trials; (2) test culturally appropriate behavioral strategies for maximizing the success of interventions; and (3) maintain interdisciplinary partnerships within cancer health disparities and HIV-related clinical trials research.

The main goal of this supplemental program is to increase participation of diverse under-represented populations (e.g., racial/ethnic groups, low SES, rural) in AMC clinical trials. To meet the goal of the supplement, eligible awardees requesting supplemental funding need to propose testing a behavioral strategy for increasing clinical trials awareness, accrual, adherence and/or retention within one or more diverse under-represented populations. The administrative supplement program is anticipated to be highly competitive with limited funding.

Behavioral strategies to be proposed for supplemental funding should be derived from theories or models demonstrated to have efficacy in diverse populations. Behavioral strategies may focus on the individual patient, groups, providers, or a combination. The behavioral strategy will be tested within an intervention currently utilized with the target population, or that is within the scope of the parent grant; such as, patient navigation, case management, community outreach, or community health education in HIV-related malignancy clinical trials. As such, requests for supplements must demonstrate that strategies under consideration address issues specific to the selected target population/s. For example, investigators proposing the studies on members of a particular racial/ethnic population in the U.S. who are dually infected with HIV/HPV would need to consider the specific mediators (e.g., self-efficacy, social relatedness, religiosity) and modifiers (e.g., comorbidity, age, insurance status) that could have an impact on participation in HIV-related malignancy clinical trials. Previously tested strategies may be modified in order to account for the social context and critical issues demonstrated to be prevalent in people living with HIV/AIDS (PLWHA); e.g., psychological or physical comorbidity, history of sexual or physical abuse, stigma, low income, or lack of insurance.

Budget and Funding Information

A total of $1.15 million is available in FY 2011 for the program. Administrative supplement requests may not exceed $300,000 in total costs. Supplements may be renewable in FY 2012 and FY 2013 based on scientific progress and availability of funds.

Eligibility

These administrative supplements are available to the awardees of the following NCI programs:  CRCHD’s Community Networks Program Centers (CNP-C) (U54), or Partnerships to Reduce Cancer Health Disparities (PRCHD) (U54, P20), as well as, the AIDS Malignancy Consortium (AMC) (U01), and the Community Cancer Clinical Oncology Program/Minority-Based Community Cancer Clinical Oncology Program (CCOP/MB-CCOP) Groups (U10). Please contact the Program Director assigned to the parent grant for questions related to scientific or programmatic content and to determine if the supplement fits within the approved scope of the project.

Investigators requesting supplements must meet the following conditions:

To be eligible, the parent grant must be active, and the research proposed in the supplement must be accomplished within the competitive segment. The proposed supplement must be within the general scope of the peer-reviewed activities and aims approved within the parent grant.

IMPORTANT:  The research proposed by the NIH grantee in the supplement application must be within the original scope of the NIH-supported grant project.  The funding mechanism being used to support this program, administrative supplements, can be used to cover cost increases that are associated with achieving certain new research objectives as long as they are within the original scope of the project.  Any cost increases need to result from making modifications to the project in order to take advantage of opportunities that would increase the value of the project consistent with its originally approved objectives and purposes. Please contact the Program Director assigned to the parent grant for questions related to scientific or programmatic content and to determine if the supplement fits within the approved scope of the project.

Submitting an Administrative Supplement Request

To be considered for an administrative supplement, the request must be signed by the Authorized Organizational Representative/Signing Official (AOR/SO), and must describe the need for additional funding and provide detailed budgets.

This Notice is a one-time announcement and formal requests must be received on or before July 22, 2011.  Applications must be signed by the Authorized Organizational Representative (AOR) at the grantee institution.

Applicants are strongly encouraged to submit requests electronically as an e-mail attachment in PDF format; however, the signature of the AOR must be clearly visible.  The e-mail address for electronic submission is: martha.hare@nih.gov. In addition, the applicant must send an electronic copy to the Program Director for the parent grant.

If preferred, a hard copy of the request packet (with original signatures of the authorized business official) may be sent to:

Martha L. Hare, PhD, RN
Program Director
Center to Reduce Cancer Health Disparities
National Cancer Institute (NCI)
6116 Executive Boulevard; Suite 602, MSC 8341
Rockville, MD 20852
Telephone: (301) 594-1908
Fax: (301) 435-9225 (fax)
martha.hare@nih.gov

In addition, submit one original, hard copy of the request packet (with original signatures of the authorized business official) to the address listed below:

Carol Perry
Team Leader, DCTD Grants Branch
Office of Grants Administration (OGA)
National Cancer Institute (NCI)
6120 Executive Boulevard, EPS Room 243
Bethesda, MD 20892-7150 (for U.S. Postal Service express or regular mail)
Rockville, MD 20852 (for non-USPS delivery)
Telephone: (301) 496-7800
Fax: (301) 496-8601
Email: Perryc@gab.nci.nih.gov

Requests should be submitted on the PHS398 Application Guide forms (font size and other formatting rules apply as designated in the instructions), as indicated below.

Include only the following elements:

1. Cover Letter which cites this Notice, and the following information:                                    

2. PHS 398 Form Page 1 (Face page)

3. PHS 398 Form Page 2

4. A brief proposal (not to exceed 6 pages) describing the project, including:

5. Budget for the supplement with a justification that details the items requested, including Facilities and Administrative costs. In addition, the budget format should be the same as that used for the parent grant i.e. modular or detailed. If a no cost extension is necessary, it must be in place per the applicable automatic or prior approval procedures before a supplement request can be awarded.

6. Biographical Sketch for all new key personnel (those who are additions on the supplemental project

7. Human Subjects/ Vertebrate Animal documentation (if applicable).

Selection

Administrative supplement requests will be reviewed administratively by NIH Staff. Selection factors will include the following:

Inquiries

Inquiries and discussion of plans for responding to this Notice are strongly encouraged.
Responses to this Administrative Supplement announcement should be submitted to the Program Director for the Parent Grant with a copy to:

Ms. Traci Mitchell
Program Analyst
Center to Reduce Cancer Health Disparities (CRCHD)
National Cancer Institute (NCI)
Telephone: (301) 435-9222
E-mail: mitchelltr@mail.nih.gov

General inquiries and copies of responses may also be sent to:

Martha L. Hare, Ph.D., RN
Program Director
Center to Reduce Cancer Health Disparities (CRCHD)
National Cancer Institute (NCI)
Telephone: (301) 594-1908       
E-mail: martha.hare@nih.gov


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