RAPID ACCESS TO PREVENTIVE INTERVENTION DEVELOPMENT - RAPID - ADDENDUM Release Date: July 13, 2000 NOTICE: CA-00-021 National Cancer Institute Investigators are hereby notified that the receipt date for requests for RAPID resources has been changed to November 21, 2000. Investigators are further notified that the website for the RAPID initiative has been updated, see http://dcp.nci.nih.gov/CB/. The Rapid Access to Preventive Intervention Development (RAPID) makes available to academic investigators the preclinical and early clinical drug development contract resources of NCI’s Division of Cancer Prevention. The goal of RAPID is the rapid movement of novel molecules and concepts from the laboratory to the clinic for clinical trials of efficacy. RAPID will assist investigators who submit successful requests by providing any (or all) of the pre-clinical and phase 1 clinical developmental requirements for phase 2 clinical efficacy trials. These include, for example, preclinical pharmacology, toxicology, and efficacy studies, bulk supply, GMP manufacturing, and formulation, and regulatory and IND support and phase 1 clinical studies. INQUIRIES: Inquiries are encouraged, and the opportunity to clarify issues or answer questions is welcome. Inquiries may be directed to: RAPID c/o James A. Crowell, Ph.D. Division of Cancer Prevention, NCI Executive Plaza North, Suite 200B 6130 Executive Blvd., Rockville, MD 20852 (overnight mail) 9000 Rockville Pike, Bethesda, MD 20892 (regular mail) Telephone (301) 496-8563 Fax (301) 402-0553 email inquiries to: jc94h@nih.gov

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