BAA ANNOUNCEMENT: Targeted Clinical Trials to Reduce the Rish of Antimicrobial Resistance - BAA-NIAID-DMID-NIHAI2008025

Notice Number: NOT-AI-08-051

Key Dates
Release Date:  May 23, 2008

Issued by
National Institutes of Allergy and Infectious Diseases (NIAID), (http://www.niaid.nih.gov)

Description

The National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), of the Department of Health and Human Services (DHHS) supports research related to the basic understanding of microbiology and immunology leading to the development of vaccines, therapeutics, and medical diagnostics for the prevention, treatment, and diagnosis of infectious and immune-mediated diseases.  The NIAID, Division of Microbiology and Infectious Diseases has a requirement to support research identifying ways to effectively treat bacterial infections with antimicrobials that minimize the development of drug resistance.

This BAA targets infectious diseases where improved treatment strategies could reduce the risk of antimicrobial resistance and preserve the effectiveness of existing antimicrobials.  A central goal of this solicitation is to target disease areas experiencing the greatest antimicrobial selective pressure, and within these areas, develop strategies that test the safety and effectiveness of different therapeutic approaches/regimens that reduce the probability of the emergence of drug resistance by minimizing unnecessary drug exposure.

Contracts to be awarded under this BAA will support the design and conduct of Phase III and/or Phase IV clinical trials of new strategies for the use of licensed, off-patent antimicrobial therapies to reduce the risk of antimicrobial resistance in selected infectious diseases. 

For the purposes of this BAA, the disease areas of interest are the following:

Both community- and hospital-associated infections in these disease areas are eligible.
 
For the purposes of this BAA, the experimental variables of interest are the following:

Eligible strategies may include, but are not limited to:

The NIAID estimates that the total cost (direct and indirect costs combined) available for all contract awards is $9.1 million per year.  However, it is anticipated that the total cost for the award(s) may vary depending upon the scope of the project and the technical objectives of the award(s).  The length of time for which funding is requested should be consistent with the nature and complexity of the proposed research.  In no event shall the period of performance proposed by an offeror exceed seven years.

It is anticipated that multiple cost reimbursement, completion type contracts will be awarded for a period of seven years, beginning approximately June 1, 2009.  BAA-NIAID-DMID-NIHAI2008025 will be available electronically on or about May 12, 2008,and may be accessed at http://www.fedbizopps.gov/.  Only electronic copies of the BAA will be available.  All information required for the submission of an offer will be contained in the BAA.  Responses to this BAA will be due on/before September 12, 2008. 

All responsible sources may submit a proposal which shall be considered by the Agency.  This BAA will be available electronically on/about May 12, 2008, and may be accessed through FedBizOpps http://www.fbo.gov/.  This notice does not commit the Government to award a contract.  No collect calls will be accepted.  No facsimile transmissions will be accepted.

Inquiries

For questions or further information, contact:

Frank Vidergar
Contract Specialist
Office of Acquisitions, Division of Extramural Activities, NIAID, NIH, DHHS
6700-B Rockledge Drive, Room 3214, MSC 7612
Bethesda, MD  20892-7612 (Express mail:  Use Zip Code 20817-7612)
Phone 301-402-1490
Fax 301-402-0972
Email vidergarf@niaid.nih.gov

Teresa A. Baughman
Contracting Officer
Office of Acquisitions, Division of Extramural Activities, NIAID, NIH, DHHS
6700-B Rockledge Drive, Room 3214, MSC 7612
Bethesda, MD  20892-7612 (Express mail:  Use Zip Code 20817-7612)
Phone 301-451-3690
Fax 301402-0972
Email baughmat@niaid.nih.gov


Weekly TOC for this Announcement
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