INTERNATIONAL COLLABORATIONS IN INFECTIOUS DISEASE RESEARCH (ICIDR)

RELEASE DATE:  May 17, 2004

NOTICE:  NOT-AI-04-030 (Update - see RFA-AI-09-010)

National Institute of Allergy and Infectious Diseases (NIAID)
  (http://www.niaid.nih.gov/)

APPLICATION RECEIPT DATE: October 13, 2004

PURPOSE

The National Institute of Allergy and Infectious Diseases (NIAID) is amending 
RFA-AI-04-017, published on April 23, 2004 
(http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-04-017.html), to 
broaden the scope of clinical research to be supported under the ICIDR 
program to include (1) tropical diseases caused by NIAID Category A, B and C 
priority pathogens (listed at 
http://www.niaid.nih.gov/biodefense/bandc_priority.htm)  and (2) additional 
tropical infections.  The RFA as published was limited to research on 
diseases caused by tropical parasites.  This notice provides additional 
information only and is not a replacement of the original RFA.  

Scope of Research

NIAID maintains a strong commitment to international research related to 
infectious diseases.  

Recognizing that many of the priority biodefense pathogens cause diseases of 
great global health importance, NIAID has restructured parts of the 
international clinical research program to accelerate efforts in these areas.  
As part of this restructuring, the ICIDR program is being expanded to include 
the NIAID Category A, B and C priority pathogens 
(http://www.niaid.nih.gov/biodefense/bandc_priority.htm) that are endemic in 
tropical regions.

In addition, this Notice expands the ICIDR program to include other 
infectious diseases that are primarily endemic in, or which 
disproportionately impact, the health of people living in the tropics, 
including but not limited to protozoan and helminth infections, mycobacterial 
disease, and bacterial and viral infections.  The focus of the ICIDR program 
remains on clinical studies, including natural history, epidemiology, and 
clinical trials (interventional studies).  

Applications proposing clinical studies in the following areas are 
particularly encouraged:

o NIAID Category A, B and C priority pathogens 
(http://www2.niaid.nih.gov/Biodefense/bandc_priority.htm), that are endemic 
in tropical regions, especially enterotoxigenic E. coli, Shigella, 
hantaviruses, dengue, rift valley fever, Japanese encephalitis virus and West 
Nile virus
o leprosy and Buruli ulcer 
o hepatitis C outcome differences
o hepatitis E in pregnant women
o sexually transmitted infections: bacterial vaginosis,  Haemophilus ducreyi 
and trichomoniasis

Studies that focus on human immunodeficiency virus (HIV) or the impact of 
other tropical diseases on HIV infection are not within the scope of this 
RFA.  In addition, studies of sexually transmitted infections (except as 
noted above), hepatitis (except as noted above), influenza, HSV1&2, RSV, and 
rotavirus in developing countries are supported by other NIAID activities and 
are not within the scope of this RFA.  

Investigators interested in biodefense-related research are also advised to 
review PA-AI-03-080, BIODEFENSE AND EMERGING INFECTIOUS DISEASE RESEARCH 
OPPORTUNITIES, which supports basic research, as well as epidemiology and 
natural history studies of biodefense related agents (Category A, B and C).  
(See http://grants.nih.gov/grants/guide/pa-files/PA-03-080.html and 
http://www2.niaid.nih.gov/biodefense/rfalplat.htm).

FUNDS AVAILABLE

NIAID intends to commit an additional $3M for a total of approximately $10.5M 
in FY 2005 to fund 10 15 new/and or competitive continuation grants in 
response to this expanded RFA.   

SPECIAL REQUIREMENTS

SELECT AGENTS: All applicant organizations, domestic and foreign, must comply 
with Select Agent regulations (http://www.cdc.gov/od/sap/) and NIH Guidelines 
for Research Involving Recombinant DNA Molecules 
(http://www4.od.nih.gov/oba/rac/guidelines/guidelines.html).  Applicants must 
document their ability and willingness to comply.

INQUIRIES

We encourage your inquiries concerning this notice and welcome the 
opportunity to answer questions from potential applicants:

Direct questions about scientific/research issues to:

Enteric Bacterial and Viral Pathogens:
Lillian van de Verg, Ph.D.
Division of Microbiology and Infectious Diseases
National Institute of Allergy and Infectious Diseases
Room 4007, MSC-6604
6610 Rockledge Drive
Bethesda, MD 20892-6603 
Telephone:  301-496-7051
FAX:  301-402-1456
Email: lv67u@nih.gov

Parasitic Diseases:
Elizabeth S. Higgs, MD, DTMH, MIA
Division of Microbiology and Infectious Diseases
National Institute of Allergy and Infectious Diseases
Room 5067, MSC-6604
6610 Rockledge Drive
Bethesda, MD 20892-6603 
Telephone: 301-402-8372 
FAX: 301-402-0659 
Email: eh63a@nih.gov 

Malla R. Rao, DrPH, M.Eng
Division of Microbiology and Infectious Diseases
National Institute of Allergy and Infectious Diseases, DHHS
Room 5095, MSC-6604
6610 Rockledge Drive
Bethesda, MD 20892
Telephone: 301- 451-3749
FAX: 301-402-0659
Email: mr8u@nih.gov 

Respiratory Infections, Leprosy, and Buruli Ulcer:
Michael Kurilla, MD, Ph.D.
Respiratory Diseases Branch 
Division of Microbiology and Infectious Diseases
National Institute of Allergy and Infectious Diseases
National Institutes of Health, DHHS
Room 5030
6610 Rockledge Drive; MSC 6603
Bethesda, MD 20892-6603
Telephone: 301-496-5305
FAX: 301-496-8060
Email: mkurilla@niaid.nih.gov

Sexually Transmitted Infections:
Barbara Savarese, RN, BScN
Clinical Research Program Officer
STD Branch
Division of Microbiology and Infectious Diseases
National Institute of Allergy and Infectious Diseases
National Institutes of Health, DHHS
6610 Rockledge Drive 
Room 5033
Bethesda, MD 20892
Telephone: 301.402.8618
Email: bs30g@nih.gov

Viral Hepatitis:
Rajen Koshy, Ph.D. 
Division of Microbiology and Infectious Diseases
National Institute of Allergy and Infectious Diseases
Room 4010, MSC-6604
6610 Rockledge Drive
Bethesda, MD 20892-6603 
Telephone:  301-496-7051
FAX:  301-402-1456
Email: rk133f@nih.gov

Viral Pathogens:
David Morens, MD.
Virology Branch
Division of Microbiology and Infectious Diseases
National Institute of Allergy and Infectious Diseases
National Institutes of Health, DHHS
Room 4097
6610 Rockledge Drive; MSC 
Bethesda, MD 20892-6603
Telephone: 301-496-7453
Email: dmorens@niaid.nih.gov

Zoonoses (other than enterics and viruses):
Anthony Macaluso, Ph.D.
Bacteriology and Mycology Branch
Division of Microbiology and Infectious Diseases
National Institute of Allergy and Infectious Diseases
National Institutes of Health, DHHS
Room 4120
6610 Rockledge Drive; MSC 6604
Bethesda, MD 20892-6604
Telephone: 301-402-0643
FAX: 301-402-2508
Email: am357x@nih.gov

Direct questions about the overall international program to:

Polly R. Sager, Ph.D.
Assistant Director for International Research in Infectious Diseases
Division of Microbiology and Infectious Diseases
National Institute of Allergy and Infectious Diseases
National Institutes of Health, DHHS
Room 6005
6610 Rockledge Drive; MSC 7630
Bethesda, MD 20892-7630
Telephone: 301-496-1884
Email:  psager@niaid.nih.gov

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