NIAID RESEARCH PROGRAMS FOR TOPICAL MICROBICIDES RELEASE DATE: March 22, 2004 NOTICE: NOT-AI-04-021 National Institute of Allergy and Infectious Diseases (NIAID) (http://www.niaid.nih.gov) National Institute of Child Health and Human Development (NICHD) (http://www.nichd.nih.gov/) DESCRIPTION This Notice is to highlight microbicide research opportunities sponsored by NIH. The grant and contract programs shown here integrate to provide a complete research path from earliest discovery through proof of concept testing. The NIH is seeking applications at each stage of development to bolster the breadth and depth of the science we are supporting. A brief description of each program follows. INNOVATION GRANTS FOR AIDS RESEARCH - PA 02-046 (http://grants.nih.gov/grants/guide/pa-files/PA-02-046.html) This PA seeks applications at the earliest steps in the microbicide development pathway. This solicitation seeks the submission of applications to bring new, scientifically challenging and untested ideas into AIDS research including microbicides. In brief, the sponsoring NIH institutes are seeking applications in the following areas for this PA: Microbicide discovery - objectives may include, but are not limited to, new approaches for microbicides addressing: o viral and cellular processes involved in the transmission, local propagation, and spread of HIV o processes for cervicovaginal and rectal transmission of HIV o improved methods of formulation and delivery o preclinical systems to test microbicide safety and efficacy INTEGRATED PRECLINICAL/CLINICAL PROGRAM FOR TOPICAL MICROBICIDES PAR-03-137 (http://grants.nih.gov/grants/guide/pa-files/PAR-03-137.html) This solicitation provides opportunities to advance safe, novel topical microbicides and microbicide combination strategies that prevent the sexual transmission of HIV, from preclinical to clinical studies. This purpose of this program is: (1) to encourage discovery and preclinical development of lead topical microbicide candidates and combinations, and (2) to foster translation of safe, new microbicides/ combinations from preclinical studies to pilot clinical studies. The ultimate goal of this research is the development and exploratory clinical evaluation of new and potentially effective microbicides for the prevention of HIV sexual transmission. HIV MICROBICIDE DESIGN AND DEVELOPMENT TEAMS RFP-NIH-NIAID-DAIDS-04-04 http://www.niaid.nih.gov/contract/rfps.htm The HIV Microbicide Design and Development Teams (HMDDT) solicitation seeks to fund consortia of scientists with product development experience from industry and/or academia that have 1) identified a promising microbicide concept, and 2) devised a plan for its targeted development in to a product testable in humans. The expectation is that the Teams advance their microbicide concepts along a well-defined development path in a timely manner to a microbicide product and in to clinical testing with the five-year period of the award. WHERE TO SEND INQUIRIES We encourage inquiries concerning these announcements and welcome the opportunity to answer questions from potential applicants. Inquiries may fall into three areas: scientific/research, peer review, and financial or grants management issues: o Direct your questions about NIAID scientific/research issues to: Dr. Roberta Black Division of AIDS National Institute of Allergy and Infectious Diseases Room 4110, MSC-7628 6700-B Rockledge Drive Bethesda, MD 20892-7628 Telephone: (301) 496-8199 FAX: (301) 496-8530 E-Mail: rb31i@nih.gov o Direct your questions about NICHD scientific/research issues to: Dr. Patricia Reichelderfer Center for Population Research National Institute of Child Health and Human Development Room 8B13G, MSC 7510 6100 Executive Boulevard Bethesda, MD 20892-7510 Telephone: 301-496-1661 FAX: 301-480-1972 E-mail: pr20f@nih.gov o Direct questions about financial or grants management matters to: Jane Unsworth Division of Extramural Activities National Institute of Allergy and Infectious Diseases Room 2128, MSC-7614 6700-B Rockledge Drive Bethesda, MD 20892-7614 Telephone: (301) 402-6824 FAX: (301) 480-3780 Email: ju3a@nih.gov o Direct questions about contract management matters to: Donald E. Collie Contracts Management Specialist Division of Extramural Activities National Institute of Allergy and Infectious Diseases Room 2233, MSC-7612 6700-B Rockledge Drive Bethesda, MD 20892-7614 Telephone: (301) 496-0992 FAX: (301) 402-0972 Email: dcollie@niaid.nih.gov

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