RFP ANNOUNCEMENT: HIV VACCINE DESIGN AND DEVELOPMENT TEAMS - RFP-NIH-NIAID-DAIDS-04-42 RELEASE DATE: November 10, 2003 NOTICE: NOT-AI-04-006 National Institute of Allergy and Infectious Diseases (NIAID) (http://www.niaid.nih.gov) RECEIPT DATE: February 19, 2004 DESCRIPTION The Division of Acquired Immune Deficiency Syndrome (DAIDS) of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), has a requirement for the development of efficacious preventative and therapeutic vaccines against HIV/AIDS for worldwide use in stemming the AIDS epidemic. To augment the vaccine product pipeline, we are seeking opportunities to advance vaccine concepts toward the product stage via a focused, development-based approach. Specifically, the long-range goal of this solicitation is the development of new safe and immunogenic vaccine candidates that merit further evaluation in larger human trials. The HIV Vaccine Design and Development Teams (HVDDT) solicitation seeks to fund consortia of scientists with development experience from industry and/or academia that have 1) identified a promising vaccine concept, and 2) devised a plan for its targeted development into a vaccine product. A vaccine product is defined here to be a material and its manner of administration that could reasonably provide protection against AIDS. Offerors are encouraged, but not required to conduct phase I/II trials in collaboration with NIAID/DAIDS-supported HIV/AIDS vaccine trials networks. Support for phase III studies will not be funded under this solicitation. It is anticipated that up to four (4) cost reimbursement, completion type contracts will be awarded for a period of five (5) years, beginning approximately September 30, 2004. RFP-NIH-NIAID-DAIDS-04-42 will be available electronically on or about November 18, 2003, and may be accessed through the NIAID Contract Management Branch (CMB) Home Page by using the following electronic address and instructions: NIAID/CMB Home Page (via the World Wide Web): Access by using http://www.niaid.nih.gov/contract and select the RFPs link and then select RFP-NIH-NIAID-DAIDS-04-42. It will also be posted on FedBizOpps at http://www.fedbizopps.gov/. Please note that the RFP for this acquisition has been revised to include only the Work Statement, deliverable and reporting requirements, special requirements and mandatory qualification, if any, the Technical Evaluation Criteria, and the proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and the initial review process, Offerors comprising the competitive range will be requested to provide additional documentation to the Contracting Officer. Responses to this RFP will be due on February 19, 2004. Any responsible Offeror may submit a proposal that will be considered by the Government. This advertisement does not commit the Government to award a contract. No collect calls will be accepted. Contracting Office Address: Department of Health and Human Services National Institutes of Health National Institutes of Allergy and Infectious Diseases Contract Management Branch 6700-B Rockledge Drive Room 2230, MSC 7612 Bethesda, MD, 20892-7612 Point of Contact: Janet M. Mattson, Contracting Officer, Phone 301-496-0993, Fax 301-480-5253, Email: jm32u@nih.gov

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