BANKING GENETIC SAMPLES FROM NIA-FUNDED STUDIES THROUGH THE NIA AGED CELL BANK RELEASE DATE: January 15, 2004 NOTICE: NOT-AG-04-002 National Institute on Aging (NIA) (http://www.nia.nih.gov/) The National Institute on Aging (NIA) offers investigators assistance with archiving and sharing cell lines from genetic studies funded through the NIA. Many epidemiological and clinical studies include collection of blood samples and generation of transformed lymphoblastoid cell lines as a renewable source of DNA. These collections of genetic samples from population-based studies and case-control studies are valuable resources and it is in the best interests of all the NIH, the research community, and the taxpayers who fund the research and benefit from the results for maximum use to be made of these resources. The NIH sharing policy urges that unique resources developed from NIH-funded research be made available to the research community (Sharing Biomedical Research Resources, http://ott.od.nih.gov/NewPages/64FR72090.pdf ). Disseminating large numbers of cell lines could be burdensome to investigators, so the NIA will assist sharing of cell lines through the NIA contract-supported Aged Cell Bank. The following services are available to NIA grantees through the contractor for the NIA Aged Cell Bank, Coriell Institute for Medical Research: o Preparation of transformed cell lines from blood samples and all related quality control o Preparation of DNA for use by the study investigators o Expansion and cryopreservation of the cell lines o Preparation of DNA for archiving and sharing o Sharing of cell lines and DNA by inclusion in the Aged Cell Bank catalog NIA grantees can opt to use the Aged Cell Bank for generation and banking of cell lines or for banking of cell lines produced in their labs. The first four bullets above must be funded through the grant budget; the fifth bullet is covered by the NIA contract for the Aged Cell Bank. For development of grant budgets, information on the costs associated with each of these services is available from the NIA and should be requested well in advance of the application deadline. Requests for information should be made to: Nancy L. Nadon, Ph.D. Head, Office of Biological Resources and Resource Development National Institute on Aging nadonn@nia.nih.gov 301-402-7744 The NIA has instituted an explicit sharing policy specific to the area of human Alzheimer’s Disease genetics that applies to all NIA-funded research in the area of Alzheimer’s Disease genetics regardless of cost. The relevant documents can be accessed at http://www.nia.nih.gov/ResearchInformation/ FundingAndTraining/Policies/SharingResources.htm and http://www.nia.nih.gov/NR/ rdonlyres/380C4ADE-581B-4700-A869-03DF0A79AAD6/3072/geneticsguidance.doc For further information, please contact: Marilyn M. Miller, Ph.D. Program Director, Etiology of Alzheimer's Disease - Genetics National Institute on Aging MillerM@nia.nih.gov 301-496-9350


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